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Metabolic signature of methylone in primary mouse hepatocytes, at subtoxic concentrations
Methylone (3,4-methylenedioxymethcathinone) is one of the most popular new psychoactive drugs worldwide. Although advertised as a safe drug, its use...
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Green analytical toxicology method for determination of synthetic cathinones in oral fluid samples by microextraction by packed sorbent and liquid chromatography–tandem mass spectrometry
PurposeWe developed and validated a method for quantitative analysis of ten synthetic cathinones in oral fluid (OF) samples, using microextraction by...
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Pharmacokinetics of Synthetic Cathinones Found in Bath Salts in Mouse Brain and Plasma Using High-Pressure Liquid Chromatography–Tandem Mass Spectrometry
Background and ObjectivesApproximately 10 years ago, “bath salts” became popular as legal alternatives to the psychostimulants cocaine and the...
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Methylone and pentylone: structural analysis of new psychoactive substances
PurposeThe growing availability of new psychoactive substances with unknown toxicity is alarming all over the world. The simplicity of acquiring...
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Dopaminergic Effects of Major Bath Salt Constituents 3,4-Methylenedioxypyrovalerone (MDPV), Mephedrone, and Methylone Are Enhanced Following Co-exposure
Designer drug mixtures popularized as “bath salts” often contain the synthetic cathinones 3,4 methylenedioxypyrovalerone (MDPV), mephedrone, and...
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Relative reinforcing effects of dibutylone, ethylone, and N-ethylpentylone: self-administration and behavioral economics analysis in rats
RationaleFollowing the emergence of methylone as one of the most popular synthetic cathinones, this group of novel psychoactive substance with names...
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Cardiotoxicity After Synthetic Cathinone Use; Two Cases, A Case Series and Sco** Review
The cardiotoxic effects of synthetic cathinones remain largely unknown. In this study, we present two cases, a case series and a sco** review, to...
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Behavioral economic analysis of the reinforcing effects of “bath salts” mixtures: studies with MDPV, methylone, and caffeine in male Sprague-Dawley rats
Rationale“Bath salts” preparations often contain combinations of synthetic cathinones (e.g., 3,4-methylenedioxymethcathinone [methylone],...
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Target Analysis of NPS in Oral Fluid
The need to identify and quantify a growing number of NPS represents a crucial challenge for toxicological and forensic purposes. Among biological...
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Target Analysis of Synthetic Cathinones in Blood and Urine
Synthetic cathinones are new psychoactive substances which act as central nervous system stimulants with mixed sympathomimetic activity. In the last...
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A systematic review and meta-analysis of synthetic cathinone use and psychosis
RationaleSynthetic cathinones (SC), commonly referred to as “bath salts”, are stimulants resembling the natural alkaloid cathinone found in the khat ...
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Target Analysis of NPS in Alternative Matrix Hair
An overview of the detection of novel psychoactive substances (NPS) and their detection in hair is provided. The overview focuses on the major NPS...
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Metabolism of synthetic cathinones through the zebrafish water tank model: a promising tool for forensic toxicology laboratories
PurposeThe aim of this study was to identify in vivo phase I metabolites of five psychoactive substances: N -ethylpentylone, ethylone, methylone,...
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Influence of long-term storage temperatures and sodium fluoride preservation on the stability of synthetic cathinones and dihydro-metabolites in human whole blood
PurposeSynthetic cathinones, one of the largest groups of new psychoactive substances, represent a large analytical and interpretative challenge in...
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The Use and Abuse of Synthetic Cathinones (aka “Bath Salts”)
The synthetic cathinones are derivatives of the stimulant cathinone naturally found in the khat plant (Catha edulis). They are β-ketone analogs of...
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The Use and Abuse of Synthetic Cathinones (aka “Bath Salts”)
The synthetic cathinones are derivatives of the stimulant cathinone naturally found in the khat plant (Catha edulis). They are β-ketone analogs of...
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Cognitive Deficits and Synthetic Khat-Related Cathinones
The psychoactive shrub Catha edulis (khat or qat) has been used by humans for centuries due to the psychoactive properties of its endogenous alkaloid...
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Cognitive Deficits and Synthetic Khat-Related Cathinones
The psychoactive shrub Catha edulis (khat or qat) has been used by humans for centuries due to the psychoactive properties of its endogenous alkaloid...
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Effects of Amphetamine-Type Stimulants on the Metabolome
Amphetamine-type stimulants such as methamphetamine, amphetamine, 3,4-methylenedioxymethamphetamine (MDMA), or chemically similar new psychoactive...
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Effects of Amphetamine-Type Stimulants on the Metabolome
Amphetamine-type stimulants such as methamphetamine, amphetamine, 3,4-methylenedioxymethamphetamine (MDMA), or chemically similar new psychoactive...