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The methylation level of a single cancer risk marker gene reflects methylation burden in gastric mucosa
BackgroundGastric cancer risk can be accurately predicted by measuring the methylation level of a single marker gene in gastric mucosa. However, the...
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Identification of gene-level methylation for disease prediction
DNA methylation is an epigenetic alteration that plays a fundamental part in governing gene regulatory processes. The DNA methylation mechanism...
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Methylation-Specific Electrophoresis
Methylation of CpG sites in the promoter region of genomic DNA is an important epigenetic modification that plays a critical role in gene regulation,...
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DNA Methylation as a Biomarker and Application to Aluminum: ADRB2 5′-Untranslated Region (5′-UTR) Methylation Level
Environmental heavy metal exposure might be considered as a contributor to childhood asthma development and its levels of control. Moreover, heavy...
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DNA Methylation
In this chapter, the best-understood epigenetic mark, cytosine methylation of genomic DNA, will be introduced. DNA methylation is performed by DNA...
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Lower Levels of TET2 Gene Expression, with a Higher Level of TET2 Promoter Methylation in Patients with AML; Evidence for the Role of Aberrant Methylation in AML Pathogenesis
DNA methylation is a key epigenetic mechanism that is dysregulated in leukemia and plays a significant role in leukemogenesis. Ten-eleven...
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DNA Methylation Analysis
DNA methylation of promoter CpG islands silences their downstream genes, and enhancer methylation can be associated with decreased or increased gene...
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Hybridization-based CpG methylation level detection using methyl-CpG-binding domain–fused luciferase
Hypermethylation of tumor-suppressor genes and global hypomethylation, which is related to methylation level at the retroelement, have been...
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Diagnostic value of SHOX2, RASSF1A gene methylation combined with CEA level detection in malignant pleural effusion
AimTo investigate the diagnostic value of combined detection of SHOX2 and RASSF1A gene methylation with carcinoembryonic antigen (CEA) level in...
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Prolonged culturing of colonic epithelial organoids derived from healthy individuals and ulcerative colitis patients results in the decrease of LINE-1 methylation level
Patient-derived human intestinal organoids are becoming an indispensable tool for the research of digestive system in health and disease. However,...
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Phasing DNA Methylation
Haploty** enables the study of allele-specific events. Heterozygous variants, primarily single nucleotide variants (SNVs), enable the assignment of...
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A noninvasive method for predicting clinically significant prostate cancer using magnetic resonance imaging combined with PRKY promoter methylation level: a machine learning study
BackgroundTraditional process for clinically significant prostate cancer (csPCA) diagnosis relies on invasive biopsy and may bring pain and...
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Estimating genome-wide DNA methylation heterogeneity with methylation patterns
BackgroundIn a heterogeneous population of cells, individual cells can behave differently and respond variably to the environment. This cellular...
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SOCS1 methylation level is associated with prognosis in patients with acute-on-chronic hepatitis B liver failure
BackgroundGlucocorticoids could greatly improve the prognosis of patients with acute-on-chronic hepatitis B liver failure (ACHBLF). Suppressor of...
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Identifying primary and secondary MLH1 epimutation carriers displaying low-level constitutional MLH1 methylation using droplet digital PCR and genome-wide DNA methylation profiling of colorectal cancers
BackgroundMLH1 epimutation is characterised by constitutional monoallelic MLH1 promoter hypermethylation, which can cause colorectal cancer (CRC)....
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The Generation and Recognition of Histone Methylation
The posttranslational modification of histone proteins via methylation has important functions in gene activation, transcriptional silencing,...
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Methylome Imputation by Methylation Patterns
DNA methylation is studied extensively for its relations with several biological processes such as transcriptional regulation. While methylation...
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DNA Methylation Analysis Using Bisulfite Pyrosequencing
Pyrosequencing is a DNA sequencing-by-synthesis technique that can quantitatively detect single-nucleotide polymorphisms (SNPs). With pyrosequencing,...
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Association between acetaminophen metabolites and CYP2E1 DNA methylation level in neonate cord blood in the Boston Birth Cohort
BackgroundAcetaminophen is a commonly used medication by pregnant women and is known to cross the placenta. However, little is known about the...
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pycoMeth: a toolbox for differential methylation testing from Nanopore methylation calls
We present pycoMeth , a toolbox to store, manage and analyze DNA methylation calls from long-read sequencing data obtained using the Oxford Nanopore...
