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Mitochondrial Metabolic Programming and Crosstalk to Nucleus
Purpose of ReviewThe metabolic reprogramming of immune cells is vital for an effective immune response. This review delves into the intricate...
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Tumor metabolic crosstalk and immunotherapy
Tumor cells must resist the host's immune system while maintaining growth under harsh conditions of acidity and hypoxia, which indicates that tumors...
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Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome
Chronic inflammation is currently considered as a molecular basis of metabolic syndrome. Particularly, obesity-induced inflammation in adipose tissue...
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IFNγ-IL12 axis regulates intercellular crosstalk in metabolic dysfunction-associated steatotic liver disease
Obesity is a major cause of metabolic dysfunction-associated steatohepatitis (MASH) and is characterized by inflammation and insulin resistance....
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The crosstalk between glomerular endothelial cells and podocytes controls their responses to metabolic stimuli in diabetic nephropathy
In diabetic nephropathy (DN), glomerular endothelial cells (GECs) and podocytes undergo pathological alterations, which are influenced by metabolic...
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Bone-derived PDGF-BB enhances hippocampal non-specific transcytosis through microglia-endothelial crosstalk in HFD-induced metabolic syndrome
BackgroundIt is well known that high-fat diet (HFD)-induced metabolic syndrome plays a crucial role in cognitive decline and brain-blood barrier...
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Pathway crosstalk between the central metabolic and heme biosynthetic pathways in Phanerochaete chrysosporium
AbstractA comprehensive analysis to survey heme-binding proteins produced by the white-rot fungus Phanerochaete chrysosporium was achieved using a...
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Metabolic picture of microbial interaction: chemical crosstalk during co-cultivation between three dominant genera of bacteria and fungi in medicinal plants rhizosphere
IntroductionMicrobial communities affect several aspects of the earth’s ecosystem through their metabolic interaction. The dynamics of this...
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Nutrient sensors and their crosstalk
The macronutrients glucose, lipids, and amino acids are the major components that maintain life. The ability of cells to sense and respond to...
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Metabolic crosstalk between skeletal muscle cells and liver through IRF4-FSTL1 in nonalcoholic steatohepatitis
Inter-organ crosstalk has gained increasing attention in recent times; however, the underlying mechanisms remain unclear. In this study, we elucidate...
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A novel 3D culture model for human primary mammary adipocytes to study their metabolic crosstalk with breast cancer in lean and obese conditions
Obesity is a negative prognosis factor for breast cancer. Yet, the biological mechanisms underlying this effect are still largely unknown. An...
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The lipidomic profile of the tumoral periprostatic adipose tissue reveals alterations in tumor cell’s metabolic crosstalk
BackgroundPeriprostatic adipose tissue (PPAT) plays a role in prostate cancer (PCa) progression. PPAT lipidomic composition study may allow us to...
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Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and pancreatic β-cell dysfunction, which result from the...
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Dynamic intrauterine crosstalk promotes porcine embryo implantation during early pregnancy
Dynamic crosstalk between the embryo and mother is crucial during implantation. Here, we comprehensively profile the single-cell transcriptome of pig...
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Kidney–Gut Crosstalk in Acute Kidney Injury
Gut–kidney crosstalk is one of the most complex forms of organic intercommunication in the economy since it involves not only these two organs but...
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Kidney–Lung Crosstalk in Acute Kidney Injury
Acute Kidney Injury (AKI) and Acute Lung Injury (ALI) are two everyday clinical conditions managed in hospitalization. With the concept that there is...
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Bone-organ axes: bidirectional crosstalk
In addition to its recognized role in providing structural support, bone plays a crucial role in maintaining the functionality and balance of various...
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NK cells are never alone: crosstalk and communication in tumour microenvironments
Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour microenvironment (TME) causes insufficient infiltration and poor efficacy...
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Crosstalk between muscle and bone
Clinical studies revealed a relationship between osteoporosis and sarcopenia. Based on this background, crosstalk between muscle and bone has emerged...
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Kidney–Muscle Crosstalk in Acute Kidney Injury
Muscle-kidney crosstalk in acute kidney injury represents a bidirectional axis which includes rhabdomyolysis with its characteristic leakage of...