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Toxicological effect of acetaminophen, metamizole, and nimesulide cocktail on early development of zebrafish
BackgroundSeveral countries’ most incorrectly discarded medicines are acetaminophen (ACM), metamizole (MTZ), and nimesulide (NMS). These xenobiotics...
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A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy
Mi crophthalmiat ranscriptionf actor (MITF) regulates melanocyte development and is the “lineage-specific survival” oncogene of melanoma. MITF is...
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Impairing hydrolase transport machinery prevents human melanoma metastasis
Metastases are the major cause of cancer-related death, yet, molecular weaknesses that could be exploited to prevent tumor cells spreading are poorly...
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Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma
Transfer RNA dynamics contribute to cancer development through regulation of codon-specific messenger RNA translation. Specific aminoacyl-tRNA...
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Microenvironmental Snail1-induced immunosuppression promotes melanoma growth
Melanoma is an aggressive form of skin cancer due to its high metastatic abilities and resistance to therapies. Melanoma cells reside in a...
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Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity
The circadian clock regulator Bmal1 modulates tumorigenesis, but its reported effects are inconsistent. Here, we show that Bmal1 has a...
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The podoplanin-CLEC-2 interaction promotes platelet-mediated melanoma pulmonary metastasis
BackgroundPodoplanin (PDPN) expressed on tumour cells interacts with platelet C-type lectin-like receptor 2 (CLEC-2). This study aimed to investigate...
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Orthotopic model for the analysis of melanoma circulating tumor cells
Metastatic melanoma, a highly lethal form of skin cancer, presents significant clinical challenges due to limited therapeutic options and high...
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Role of PLK1/NUMB/NOTCH in epithelial-mesenchymal transition in human melanoma
Polo-like kinase 1 (PLK1), a serine/threonine kinase, is overexpressed in melanoma and its expression has been associated with poor disease...
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Mi-2β promotes immune evasion in melanoma by activating EZH2 methylation
Recent development of new immune checkpoint inhibitors has been particularly successfully in cancer treatment, but still the majority patients fail...
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ZEB1 controls a lineage-specific transcriptional program essential for melanoma cell state transitions
Cell plasticity sustains intra-tumor heterogeneity and treatment resistance in melanoma. Deciphering the transcriptional mechanisms governing...
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Androgen receptor is a determinant of melanoma targeted drug resistance
Melanoma provides a primary benchmark for targeted drug therapy. Most melanomas with BRAF V600 mutations regress in response to BRAF/MEK inhibitors...
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Map** the single cell spatial immune landscapes of the melanoma microenvironment
Melanoma is a highly immunogenic malignancy with an elevated mutational burden, diffuse lymphocytic infiltration, and one of the highest response...
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Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity
Inhibition of T cell infiltration dampens antitumor immunity and causes resistance to immune checkpoint blockade (ICB) therapy. By in vivo CRISPR...
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Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
RAC1 P29S is the third most prevalent hotspot mutation in sun-exposed melanoma. RAC1 alterations in cancer are correlated with poor prognosis,...
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Extracellular lipidosomes containing lipid droplets and mitochondria are released during melanoma cell division
BackgroundThe incidence of melanoma is increasing worldwide. Since metastatic melanoma is highly aggressive, it is important to decipher all the...
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Androgen drives melanoma invasiveness and metastatic spread by inducing tumorigenic fucosylation
Melanoma incidence and mortality rates are historically higher for men than women. Although emerging studies have highlighted tumorigenic roles for...
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Interferon-gamma signaling promotes melanoma progression and metastasis
Interferon-gamma (IFNG) has long been regarded as the flag-bearer for the anti-cancer immunosurveillance mechanisms. However, relatively recent...
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Pulsed electric field induces exocytosis and overexpression of MAGE antigens in melanoma
Nanosecond pulsed electric field (nsPEF) has emerged as a promising approach for inducing cell death in melanoma, either as a standalone treatment or...
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Cholesterol neutralized vemurafenib treatment by promoting melanoma stem-like cells via its metabolite 27-hydroxycholesterol
Vemurafenib has been used as first-line therapy for unresectable or metastatic melanoma with BRAFV600E mutation. However, overall survival is still...
