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Matrine inhibits invasion and migration of gallbladder cancer via regulating the PI3K/AKT signaling pathway
Gallbladder cancer (GBC) is a common malignant cancer in the biliary system, which poses a serious threat to human health. It is urgent to explore...
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Matrine Alleviates Sepsis-Induced Myocardial Injury by Inhibiting Ferroptosis and Apoptosis
Matrine is a Sophora alkaloid that exerts antitumor effects on a variety of diseases, but few studies have investigated the role of matrine in...
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Matrine Mediated Immune Protection in MS by Regulating Gut Microbiota and Production of SCFAs
There is clearly an unmet need for more effective and safer treatments for multiple sclerosis (MS). Our previous studies showed a significant...
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Matrine exerts its neuroprotective effects by modulating multiple neuronal pathways
Recent evidence suggests that misfolding, clum**, and accumulation of proteins in the brain may be common causes and pathogenic mechanism for...
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Matrine alleviates depressive-like behaviors via modulating microbiota–gut–brain axis in CUMS-induced mice
BackgroundThe realization of the “microbiota–gut–brain” axis plays a critical role in neuropsychiatric disorders, particularly depression, is...
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Matrine combined with Osthole inhibited the PERK apoptosis of splenic lymphocytes in PCV2-infected mice model
BackgroundPorcine circovirus type 2 (PCV2) is one of the major pathogens commonly found in pigs, which causes immunosuppression and apoptosis....
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Matrine induces autophagy in human neuroblastoma cells via blocking the AKT-mTOR pathway
Neuroblastoma (NB) is one of the most common malignant solid tumors in children. Despite significant advances in the treatment strategy, the...
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Matrine promotes trophoblast invasion and reduces inflammation via miR-19a-3p to prevent preeclampsia
BackgroundDuring preeclampsia (PE), reactive oxygen species (ROS) production and inflammation are increased. Matrine exerts diverse pharmacological...
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Matrine-loaded self-adhesive swelling microneedle for inflammation regulation to improve eczema treatment
Eczema is a common chronic dermatological disease. Conventional treatments exhibit limited efficacy due to fast drug release resulting in short-term...
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Matrine-producing endophytic fungus Galactomyces candidum TRP-7: screening, identification, and fermentation conditions optimization for Matrine production
Matrine (MA) is an alkaloid extracted from the root of genus Sophora with various pharmacological activities. Production of MA by endophytic fungi...
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Comparative transcriptome analysis reveals differences in gene expression in whitefly following individual or combined applications of Akanthomyces attenuatus (Zare & Gams) and matrine
BackgroundBemisia tabaci Gennadius (Hemiptera: Aleyrodidae) is a serious pest of crops in different regions of the world. Our recent studies on the...
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A novel matrine derivative, WM130, inhibits activation and movement of human hepatic stellate LX-2 cells by targeting cofilin 1
Matrine , one of the active ingredients of Sophora flavescens Ait. , has a protective effect in animal models on acute liver injury and liver fibrosis....
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Reversal of gentamicin sulfate resistance in avian pathogenic Escherichia coli by matrine combined with berberine hydrochloride
In recent years, the evolution of antibiotic resistance has led to the inefficacy of several antibiotics, and the reverse of resistance was a novel...
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The effect of matrine and glycyrrhizic acid on porcine reproductive and respiratory syndrome virus in Vitro and in vivo
Porcine reproductive and respiratory syndrome (PRRS) is endemic worldwide, seriously affecting the development of the pig industry, but vaccines have...
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Sodium Selenite Prevents Matrine-Induced Nephrotoxicity by Suppressing Ferroptosis via the GSH-GPX4 Antioxidant System
Matrine (MT), an active ingredient derived from Sophor flavescens Ait , is used as a therapeutic agent to treat liver disease and cancer. However, the...
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Src acts as the target of matrine to inhibit the proliferation of cancer cells by regulating phosphorylation signaling pathways
Studies have shown that matrine has antitumor activity against many types of cancers. However, the direct target in cancer cells of its anticancer...
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Matrine suppresses cell growth of diffuse large B-cell lymphoma via inhibiting CaMKIIγ/c-Myc/CDK6 signaling pathway
BackgroundC-Myc aberrations confer a more aggressive clinic behavior in diffuse large B-cell lymphoma (DLBCL). Matrine is an alkaloid extracted from S...
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Evaluating the efficacy of osthole and matrine for control of Sorghum purple spot
Osthole is a coumarin compound extracted from the canopy flower of the umbelliferae. Matrine, whose main components are alkaloids and flavonoids, was...
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