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Asperulosidic Acid Restrains Hepatocellular Carcinoma Development and Enhances Chemosensitivity Through Inactivating the MEKK1/NF-κB Pathway
Asperulosidic acid (ASPA) is a plant-extracted iridoid terpenoid with tumor-suppressive and anti-inflammatory properties. At present, the antitumor...
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Berberine Improves TNF-α-Induced Hepatic Insulin Resistance by Targeting MEKK1/MEK Pathway
Berberine (BBR), a natural isoquinoline alkaloid exhibiting insulin sensitizing activity, has been applicated in the treatment of diabetes. However,...
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Histone deacetylase HDAC4 participates in the pathological process of myocardial ischemia-reperfusion injury via MEKK1/JNK pathway by binding to miR-206
Histone deacetylases (HDACs) and microRNAs (miRs) have been reported to exert pivotal roles on the pathogenesis of myocardial ischemia-reperfusion...
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RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling pathway in the progression of colorectal Cancer through the stabilization of MEKK1 mRNA
BackgroundMEK1/ERK signaling pathway plays an important role in most tumor progression, including colorectal cancer (CRC), however, MEK1-targeting...
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Lipid metabolism and MAPK-ICE1 cascade play crucial roles in cold tolerance of banana
Low temperature is a major environmental factor that limits the growth, yield, and geographical distribution of Cavendish and Dajiao bananas ( Musa ...
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A trimeric CrRLK1L-LLG1 complex genetically modulates SUMM2-mediated autoimmunity
Cell death is intrinsically linked with immunity. Disruption of an immune-activated MAPK cascade, consisting of MEKK1, MKK1/2, and MPK4, triggers...
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The malectin-like receptor-like kinase LETUM1 modulates NLR protein SUMM2 activation via MEKK2 scaffolding
The innate immune system detects pathogen-derived molecules via specialized immune receptors to prevent infections
1 –3 . Plant immune receptors include...
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MAPK Cascades in Plant Microbiota Structure and Functioning
Mitogen-activated protein kinase (MAPK) cascades are highly conserved signaling modules that coordinate diverse biological processes such as plant...
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Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-κβ and ASK1 Pathways
This study was designed to test whether the Cronobacter sakazakii infection-impaired contextual learning and memory are mediated by the activation of...
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Spatio-temporal expression pattern and role of the tight junction protein MarvelD3 in pancreas development and function
Tight junction complexes are involved in the establishment and maintenance of cell polarity and the regulation of signalling pathways, controlling...
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FOXA1 is a transcriptional activator of Odf2/Cenexin and regulates primary ciliation
Primary cilia are sensory organelles essential for embryonic and postnatal development, and tissue homeostasis in adulthood. They are generated in a...
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Plant Signaling and Response to Abiotic Stress
Plants are occasionally exposed to unfavorable or stressful conditions such as extreme temperature, drought, salinity, and heavy metals called...
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Genome sequence and evolution of Betula platyphylla
Betula L. (birch) is a pioneer hardwood tree species with ecological, economic, and evolutionary importance in the Northern Hemisphere. We sequenced...
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Cell Signaling Response Under Plants Stress
Stresses (mechanical, herbivore, and insect damage) are the major threats that reduce plant yield and productivity. These stresses adversely modify...
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Mitogen-Activated Protein Kinase: A Potent Signaling Protein that Combats Biotic and Abiotic Stress in Plants
Serine kinases, also identified as mitogen-activated protein kinases (MAPKs), are involved in the transmission of cellular signals that carry out...
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Transcriptome profiling of Bergenia purpurascens under cold stress
Bergenia purpurascens is an important medicinal, edible and ornamental plant. It generally grows in high-altitude areas with complex climates. There...
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Fortify the defense frontline: MAPKs phosphorylate receptor-like cytoplasmic kinase to maintain plant resistance in soybean
Mitogen-activated protein kinase (MAPK) activation is one of the significant immune events that respond to pathogens in plants. A MAPK cascade often...
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Deconvoluting signals downstream of growth and immune receptor kinases by phosphocodes of the BSU1 family phosphatases
Hundreds of leucine-rich repeat receptor kinases (LRR-RKs) have evolved to control diverse processes of growth, development and immunity in plants,...
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Molecular Mechanisms Underpinning Signaling Function of ROS
ROS are important secondary messengers, which transduce signals to trigger growth, development, and acclimatization or resistance response in plants...