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A differential diagnosis between uterine leiomyoma and leiomyosarcoma using transcriptome analysis
BackgroundThe objective of this study was to estimate the accuracy of transcriptome-based classifier in differential diagnosis of uterine leiomyoma...
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A Rare Case of Metastatic Uterine Leiomyosarcoma to the Thyroid Gland
Uterine leiomyosarcomas are malignant tumors that have a grim prognosis. These neoplasms have a high metastatic potential. Limited literature exists...
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Successful clinical approach to the metastatic uterine leiomyosarcoma to the epicardium—a case report
BackgroundUterine leiomyosarcoma is a rare and aggressive tumour with a poor prognosis. Its metastases to the heart are even rarer, especially to the...
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Preclinical activity of selinexor in combination with eribulin in uterine leiomyosarcoma
Leiomyosarcoma (LMS) is a rare soft tissue sarcoma (STS) that begins in smooth muscle tissue and most often initiates in the abdomen or uterus....
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MRI, clinical, and radiomic models for differentiation of uterine leiomyosarcoma and leiomyoma
PurposeTo assess the predictive ability of conventional MRI features and MRI texture features in differentiating uterine leiomyoma (LM) from uterine...
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Uterine Leiomyosarcoma
Uterine leiomyosarcoma is a malignant neoplasm originating from smooth muscle cells.
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Prognostic Impact of Tumor-Infiltrating Lymphocytes, Tertiary Lymphoid Structures, and Neutrophil-to-Lymphocyte Ratio in Pulmonary Metastases from Uterine Leiomyosarcoma
BackgroundThe presence of tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs) in tumor tissue has been related to the...
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The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma
Background. Uterine leiomyosarcoma is a rare aggressive smooth muscle cancer with poor survival rates. RNA Polymerase I (Pol I) activity is elevated...
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A novel morphology-based risk stratification model for stage I uterine leiomyosarcoma: an analysis of 203 cases
Uterine leiomyosarcoma is the most common uterine mesenchymal malignancy. The majority present at stage I, and clinical outcomes vary widely....
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Targeting homologous recombination deficiency in uterine leiomyosarcoma
BackgroundUterine leiomyosarcoma (uLMS) is a rare and aggressive gynaecological malignancy, with individuals with advanced uLMS having a five-year...
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Diagnostic and prognostic value of Bcl-2 in uterine leiomyosarcoma
BackgroundUterine leiomyosarcoma (uLMS) may show loss of expression of B-cell lymphoma-2 (Bcl-2) protein. It has been suggested that Bcl-2 loss may...
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Impact of Intraoperative Tumor Spillage in Uterine Leiomyosarcoma: a Retrospective Single-Institution Analysis
Uterine leiomyosarcoma is a rare female reproductive system tumor which is difficult to distinguish from uterine leiomyoma preoperatively. Manual and...
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Pulmonary vein thrombosis associated with metastatic uterine leiomyosarcoma: a case report
BackgroundPulmonary vein thrombosis (PVT) is rarely associated with malignancies. Leiomyosarcoma, a malignant tumor originating from smooth muscles,...
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Evaluation of Hedgehog Pathway Inhibitors as a Therapeutic Option for Uterine Leiomyosarcoma Using the Xenograft Model
Uterine leiomyosarcoma (LMS) contributes to a significant proportion of uterine cancer deaths. It is a rare and high-risk gynecological cancer. LMS...
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Identification of uterine leiomyosarcoma-associated hub genes and immune cell infiltration pattern using weighted co-expression network analysis and CIBERSORT algorithm
BackgroundWhile large-scale genomic analyses symbolize a precious attempt to decipher the molecular foundation of uterine leiomyosarcoma (ULMS),...
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FGFR4 promotes nuclear localization of GABP to inhibit cell apoptosis in uterine leiomyosarcoma
Fibroblast growth factor receptor 4 (FGFR4) has been indicated as a potential “oncogene” in various types of cancer. However, the effects and...
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Synergistic effects of pazopanib and hyperthermia against uterine leiomyosarcoma growth mediated by downregulation of histone acetyltransferase 1
AbstractPazopanib—a multitargeted tyrosine kinase inhibitor with prominent antiangiogenic effects—has shown promise in the treatment of soft-tissue...
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Preoperative clinical characteristics scoring system for differentiating uterine leiomyosarcoma from fibroid
BackgroundMorcellation may lead to intraperitoneal spread of tumor cells, thus making prognosis of undiagnosed uterine leiomyosarcoma (ULMS) worse....
