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Anti-aging as a Key Challenge for the Medicine of the Future
The title of this chapter expresses well not only its main idea, but also formulates one of the key ideas of the whole book. Grinin et al. give many...
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Effects of Wenyang Zhenshuai Granules on the Expression of Key Mitochondrial Autophagy Proteins in the Doxorubicin-Induced Model of H9c2 Cardiomyocyte Injury
This study aimed to explore the effects of Wenyang Zhenshuai granules (WZG) on the morphology of cardiomyocytes, cell viability, and the expression...
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Nrf2 activation: a key mechanism in stem cell exosomes-mediated therapies
Exosomes are nano-sized membrane extracellular vesicles which can be released from various types of cells. Exosomes originating from inflammatory or...
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A Review on Caspases: Key Regulators of Biological Activities and Apoptosis
Caspases are proteolytic enzymes that belong to the cysteine protease family and play a crucial role in homeostasis and programmed cell death....
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Analysis of Key Physiological Characteristics of Portunus trituberculatus in Response to Short-Term Low Salinity Stress
Salinity is a significant environmental factor that can affect the survival, metamorphosis, growth and feeding of Portunus trituberculatus . In order...
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Potential Key Proteins, Molecular Networks, and Pathways in Perinatal Hypoxia
Perinatal hypoxia is a common risk factor for CNS development. Using bioinformatics databases, a list of 129 genes involved in perinatal hypoxia was...
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Key role of interferon regulatory factor 1 (IRF-1) in regulating liver disease: progress and outlook
Interferon regulatory factor 1 (IRF-1) is a member of the IRF family. It is the first transcription factor to be identified that could bind to the...
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AMPK: a key regulator of energy stress and calcium-induced autophagy
Autophagy is a well-known cell-survival strategy orchestrated by a conserved set of proteins. It equips the cells with mechanisms to attain...
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Chlorophyll fluorometry in evaluating photosynthetic performance: key limitations, possibilities, perspectives and alternatives
Non-destructive methods for the assessment of photosynthetic parameters of plants are widely applied to evaluate rapidly the photosynthetic...
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Regulation of Plant Responses to Temperature Stress: A Key Factor in Food Security and for Mitigating Effects of Climate Change
Among the many threats to food security, extremes of temperature, and unpredictable changes in temperature such as unseasonal frost or snowfall...
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Calcium signaling in neurodevelopment and pathophysiology of autism spectrum disorders
BackgroundAutism spectrum disorder (ASD) covers a group of neurodevelopmental disorders with complex genetic background. Several genetic mutations,...
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In silico analysis of key regulatory networks related to microfibril angle in Populus trichocarpa Hook.
Dissection of regulatory network that control wood structure is highly challenging in functional genomics. Nevertheless, due to the availability of...
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Discrimination of normal and cancerous human skin tissues based on laser-induced spectral shift fluorescence microscopy
A homemade spectral shift fluorescence microscope (SSFM) is coupled with a spectrometer to record the spectral images of specimens based on the...
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Brown adipose tissue is the key depot for glucose clearance in microbiota depleted mice
Gut microbiota deficient mice demonstrate accelerated glucose clearance. However, which tissues are responsible for the upregulated glucose uptake...
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Mitochondrial complex I density is associated with IQ and cognition in cognitively healthy adults: an in vivo [18F]BCPP-EF PET study
BackgroundMitochondrial function plays a key role in regulating neurotransmission and may contribute to general intelligence. Mitochondrial complex I...
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Mitochondrial quality control in human health and disease
Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role in regulating energy metabolism. However, their...
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Insight into the underlying molecular mechanism of dilated cardiomyopathy through integrative analysis of data mining, iTRAQ-PRM proteomics and bioinformatics
BackgroundDCM is a common cardiomyopathy worldwide, which is characterized by ventricular dilatation and systolic dysfunction. DCM is one of the most...
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Syntaphilin Inactivation Can Enhance Axonal Mitochondrial Transport to Improve Spinal Cord Injury
Mitochondria are important organelle of eukaryotic cells. They consists of a large number of different proteins that provide most of the ATP and...
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Visualizing the Invisible: Microscopy and How It Affects Our Understanding of Cells and Tissues
Microscopy is constantly improving its capacities for depicting a world that is beyond the limitations of the human visual system and is therefore...