Search
Search Results
-
Ischemia–Reperfusion Injury
Ischemia has always been associated with immediate as well as delayed adverse consequences. Restoration of perfusion to ischemic tissues can also... -
Malonate given at reperfusion prevents post-myocardial infarction heart failure by decreasing ischemia/reperfusion injury
The mitochondrial metabolite succinate is a key driver of ischemia/reperfusion injury (IRI). Targeting succinate metabolism by inhibiting succinate...
-
Ischemia–Reperfusion Injury: Molecular Mechanisms of Pathogenesis and Methods of Their Correction
Abstract —Ischemia–reperfusion is a cascade of complex and interrelated pathological processes underlying many human diseases, including such socially...
-
The roles of intracellular proteolysis in cardiac ischemia–reperfusion injury
Ischemic heart disease remains a leading cause of human mortality worldwide. One form of ischemic heart disease is ischemia–reperfusion injury caused...
-
Cardioprotective Strategies After Ischemia–Reperfusion Injury
Acute myocardial infarction (AMI) is associated with high morbidity and mortality worldwide. Although early reperfusion is the most effective...
-
Advances in lung ischemia/reperfusion injury: unraveling the role of innate immunity
BackgroundLung ischemia/reperfusion injury (LIRI) is a common occurrence in clinical practice and represents a significant complication following...
-
The ability of microRNAs to regulate the immune response in ischemia/reperfusion inflammatory pathways
MicroRNAs play a crucial role in regulating the immune responses induced by ischemia/reperfusion injury. Through their ability to modulate gene...
-
Deferoxamine attenuates visual impairment in retinal ischemia‒reperfusion via inhibiting ferroptosis
Retinal ischemia‒reperfusion (I/R) injury can cause significant damage to human retinal neurons, greatly compromising their functions. Existing...
-
Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following ischemia, exacerbating the initial tissue damage. The limited...
-
Conventional Method of Cardiac Ischemia/Reperfusion Injury in Mice
Myocardial ischemia-reperfusion injury (IRI) after myocardial ischemia, cardiac surgery, or circulatory arrest leads to adverse cardiovascular... -
The effect of post-reperfusion levosimendan in an experimental intestinal ischemia–reperfusion model
BackgroundLevosimendan has been reported to have a positive effect on ischemia–reperfusion injury. Herein, we aimed to evaluate the effects of...
-
Effect of miR-206 on lower limb ischemia–reperfusion injury in rat and its mechanism
Lower limb ischemia–reperfusion is a common pathological process during clinical surgery. Because lower limb ischemia–reperfusion usually aggravates...
-
Mechanism of Reactive Oxygen/Nitrogen Species in Liver Ischemia-Reperfusion Injury and Preventive Effect of Chinese Medicine
Liver ischemia-reperfusion injury (LIRI) is a pathological process involving multiple injury factors and cell types, with different stages....
-
Effect of 2-Week Naringin Supplementation on Neurogenesis and BDNF Levels in Ischemia–Reperfusion Model of Rats
Background: Ischemic stroke is the leading cause of mortality and disability worldwide with more than half of survivors living with serious...
-
Ferroptosis in organ ischemia–reperfusion injuries: recent advancements and strategies
Ferroptosis is a newly discovered type of regulated cell death participated in multiple diseases. Different from other classical cell death programs...
-
The Protective Role of Transcript-Induced in Spermiogenesis 40 in Cerebral Ischemia–Reperfusion Injury
Prompt reperfusion after cerebral ischemia is important to maintain neuronal survival and reduce permanent disability and death. However, the...
-
Ginsenoside Rg3 attenuates myocardial ischemia/reperfusion-induced ferroptosis via the keap1/Nrf2/GPX4 signaling pathway
BackgroundGinsenoside Rg3 is a component of ginseng that protects against myocardial ischemia/reperfusion (MI/R) injury. Ferroptosis is a new form of...
-
Ferritinophagy and Ferroptosis in Cerebral Ischemia Reperfusion Injury
Cerebral ischemia–reperfusion injury (CIRI) is the second leading cause of death worldwide, posing a huge risk to human life and health. Therefore,...
-
Identification of a mechanism promoting mitochondrial sterol accumulation during myocardial ischemia–reperfusion: role of TSPO and STAR
Hypercholesterolemia is a major risk factor for coronary artery diseases and cardiac ischemic events. Cholesterol per se could also have negative...
-
MicroRNA-specific therapeutic targets and biomarkers of apoptosis following myocardial ischemia–reperfusion injury
MicroRNAs are single-stranded non-coding RNAs that participate in post-transcriptional regulation of gene expression, it is involved in the...