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An antifouling membrane-fusogenic liposome for effective intracellular delivery in vivo
The membrane-fusion-based internalization without lysosomal entrapment is advantageous for intracellular delivery over endocytosis. However, protein...
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Combining Ultrasound-Mediated Intracellular Delivery with Microfluidics in Various Applications
Ultrasound-mediated intracellular delivery is one of the popular technologies based on membrane rupture at present. To date, ultrasound directly acts...
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Molecular Mechanisms of Intracellular Delivery of Nanoparticles Monitored by an Enzyme-Induced Proximity Labeling
Achieving increasingly finely targeted drug delivery to organs, tissues, cells, and even to intracellular biomacromolecules is one of the core goals...
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Use of stimulatory responsive soft nanoparticles for intracellular drug delivery
Drug delivery has made tremendous advances in the last decade. Targeted therapies are increasingly common, with intracellular delivery highly...
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Electroactive nanoinjection platform for intracellular delivery and gene silencing
BackgroundNanoinjection—the process of intracellular delivery using vertically configured nanostructures—is a physical route that efficiently...
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Coupling of nanostraws with diverse physicochemical perforation strategies for intracellular DNA delivery
Effective intracellular DNA transfection is imperative for cell-based therapy and gene therapy. Conventional gene transfection methods, including...
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Protein@PP-Zn nanocomplex assembled by coordination of zinc ions used for intracellular protein delivery
In recent years, intracellular delivery of protein drugs has attracted great attention, and polymer-based systems have been extensively exploited to...
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Simulation of microfluidic intracellular delivery based on the synergy of cell squeezing and electrical field
In recent years, the microfluidic squeezing method for cell intracellular delivery has demonstrated high efficiency and generalizability. This...
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High throughput intracellular delivery by viscoelastic mechanoporation
Brief pulses of electric field (electroporation) and/or tensile stress (mechanoporation) have been used to reversibly permeabilize the plasma...
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Unnatural Amino Acid Engineering for Intracellular Delivery of Protein Therapeutics
Protein drugs are a critically important therapeutic modality due to the sophisticated binding recognition, catalytic properties, and disease...
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A Dynamic Covalent Bonding-based Nanoplatform for Intracellular Co-Delivery of Protein Drugs and Chemotherapeutics with Enhanced Anti-Cancer Effect
Efficient intracellular delivery of protein drugs is critical for protein therapy. The combination of protein drugs with chemotherapeutics represents...
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Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins
Recently, targeted degradation has emerged as a powerful therapeutic modality. Relying on “event-driven” pharmacology, proteolysis targeting chimeras...
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Upconverting-photon quenching-mediated perforation influx as an intracellular delivery method using posAuNP@UCNPs nanocomposites for osteoarthritis treatment
Photoporation techniques based on plasmonic nanoparticles such as gold nanoparticles have been extensively studied for the intracellular delivery of...
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Exosome-coated oxygen nanobubble-laden hydrogel augments intracellular delivery of exosomes for enhanced wound healing
Wound healing is an obvious clinical concern that can be hindered by inadequate angiogenesis, inflammation, and chronic hypoxia. While exosomes...
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Use of nanocellulose in the intracellular delivery of biological and non-biological drugs: a review
The need for natural, biodegradable, and biocompatible nanomaterials in drug delivery led to a great deal of interest in develo**...
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Lipid Nanoparticle-Enabled Intracellular Delivery of Prime Editors
Prime editing is an advanced gene editing platform with potential to correct almost any disease-causing mutation. As genome editors have evolved,...
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Meta-Analysis of Drug Delivery Approaches for Treating Intracellular Infections
This meta-analysis aims to evaluate the trend, methodological quality and completeness of studies on intracellular delivery of antimicrobial agents....
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Multifunctional synthetic nano-chaperone for peptide folding and intracellular delivery
Artificial, synthetic chaperones have attracted much attention in biomedical research due to their ability to control the folding of proteins and...
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pH-sensitive liposomes bearing a chemotherapeutic agent and a natural apoptosis modulator for effective intracellular delivery to the solid tumor
The intracellular delivery of the drug to the solid tumor is a major challenge in the treatment of solid tumors. This project aims to increase...
