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Is Monitoring of the Intracellular Active Metabolite Levels of Nucleobase and Nucleoside Analogs Ready for Precision Medicine Applications?
Nucleobase and nucleoside analogs (NAs) play important roles in cancer therapy. Although there are obvious individual differences in NA treatments,...
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Metabolite signaling in the heart
The heart is the most metabolically active organ in the body, sustaining a continuous and high flux of nutrient catabolism via oxidative...
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Quantification of Intracellular Citrate Concentrations with Genetically Encoded Biosensors
Citrate is a central intracellular metabolite with roles in a variety of normal and aberrant biological processes. The methods for quantifying...
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Intercellular interaction mechanisms promote diversity in intracellular ATP concentration in Escherichia coli populations
In fluctuating environments, many microorganisms acquire phenotypic heterogeneity as a survival tactic to increase the likelihood of survival of the...
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Metabolite-Associated Disease Conditions
As a result of an imbalance between activation and detoxification metabolisms, reactive chemical intermediates and oxidative stress occur, leading to...
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Metabolite-Based Biosignature of Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic neoplasm and one of the leading causes of cancer-associated deaths. Lack of...
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Metabolite-Associated Cell Toxicities
Potential toxic foreign compounds or metabolites are capable of interacting with an endogenous target, triggering perturbation in cellular functions...
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Antiallergic Metabolite Production from Plants via Biotechnological Approaches
Allergic disorders pose a significant global health challenge, impacting millions. Plants, rich in bioactive compounds, have gained recognition for...
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Plant Cells: Secondary Metabolite Heterogeneity and Its Manipulation
This chapter proposes the concept of rational manipulation of secondary metabolite heterogeneity in plant cell cultures. The heterogeneity of...
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An arrhythmogenic metabolite in atrial fibrillation
BackgroundLong-chain acyl-carnitines (ACs) are potential arrhythmogenic metabolites. Their role in atrial fibrillation (AF) remains incompletely...
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Secondary Metabolite Production in Medicinal Plants under Abiotic Stress
Like other plants, medicinal and aromatic plants have evolved several mechanisms to accommodate themselves under changing environmental conditions,...
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Metabolite trafficking enables membrane-impermeable-terpene secretion by yeast
Metabolites are often unable to permeate cell membranes and are thus accumulated inside cells. We investigate whether engineered microbes can...
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Predicting intercellular communication based on metabolite-related ligand-receptor interactions with MRCLinkdb
BackgroundMetabolite-associated cell communications play critical roles in maintaining human biological function. However, most existing tools and...
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Clostridium butyricum and its metabolite butyrate promote ferroptosis susceptibility in pancreatic ductal adenocarcinoma
PurposePancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with limited therapeutic options. The diversity and composition of the...
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Vascular endothelial dysfunction induced by 3-bromofluoranthene via MAPK-mediated-NFκB pro-inflammatory pathway and intracellular ROS generation
3-Bromofluoranthene (3-BrFlu) is the secondary metabolite of fluoranthene, which is classified as a polycyclic aromatic hydrocarbon, through...
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Cholesterol neutralized vemurafenib treatment by promoting melanoma stem-like cells via its metabolite 27-hydroxycholesterol
Vemurafenib has been used as first-line therapy for unresectable or metastatic melanoma with BRAFV600E mutation. However, overall survival is still...
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Changes in intracellular energetic and metabolite states due to increased galactolipid levels in Synechococcus elongatus PCC 7942
The lipid composition of thylakoid membranes is conserved from cyanobacteria to green plants. However, the biosynthetic pathways of galactolipids,...
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Crispr Gene Editing for Secondary Metabolite Production: A Review
A variety of secondary metabolites or so-called phyto-metabolites with different biological properties and structures can be produced by medicinal...
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Quantifying intracellular glucose levels when yeast is grown in glucose media
In Saccharomyces cerevisiae , intracellular glucose levels impact glucose transport and regulate carbon metabolism via various glucose sensors. To...
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Metabolite interactions in the bacterial Calvin cycle and implications for flux regulation
Metabolite-level regulation of enzyme activity is important for microbes to cope with environmental shifts. Knowledge of such regulations can also...
