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Inflammaging and Immunosenescence
Aging remains a mysterious process, but age-associated changes in the different organ systems constituting the whole organism are well known. One of...
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Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies
Inflammaging refers to the age-related low grade, sterile, chronic, systemic, and long-lasting subclinical, proinflammatory status, currently...
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Mineralocorticoid receptor promotes cardiac macrophage inflammaging
Inflammaging, a pro-inflammatory status that characterizes aging and primarily involving macrophages, is a master driver of age-related diseases....
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Repetitive element transcript accumulation is associated with inflammaging in humans
Chronic, low-grade inflammation increases with aging, contributing to functional declines and diseases that reduce healthspan. Growing evidence...
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Inflammaging and Osteoarthritis
Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age worldwide. While in the past it was considered a mere...
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The companion dog as a model for inflammaging: a cross-sectional pilot study
Inflammaging, the chronic, progressive proinflammatory state associated with aging, has been associated with multiple negative health outcomes in...
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Reduced mitochondrial calcium uptake in macrophages is a major driver of inflammaging
Mitochondrial dysfunction is linked to age-associated inflammation or inflammaging, but underlying mechanisms are not understood. Analyses of 700...
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Epigenetic Mechanisms Involved in Inflammaging-Associated Hypertension
Purpose of ReviewThis review summarizes the involvement of inflammaging in vascular damage with focus on the epigenetic mechanisms by which...
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Glyoxal-derived advanced glycation end products (GO-AGEs) with UVB critically induce skin inflammaging: in vitro and in silico approaches
Advanced glycation end products (AGEs) have potential implications on several diseases including skin inflammation and aging. AGEs formation can be...
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Stratum corneum hydration inversely correlates with certain serum cytokine levels in the elderly, possibly contributing to inflammaging
BackgroundChronic, low-grade inflammation, also termed ‘inflammaging’, has been linked to the development of some aging-associated disorders. Recent...
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Probiotic-Reduced Inflammaging in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial
The disparity between increased lifespan and healthy aging, marked by prevalent “inflammaging”, highlights the global challenge in care of older...
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Aging, inflammaging and immunosenescence as risk factors of severe COVID-19
Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused by the novel severe acute respiratory syndrome coronavirus 2...
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Inflammaging in domestic dogs: basal level concentrations of IL-6, IL-1β, and TNF-α in serum of healthy dogs of different body sizes and ages
Inflammaging, a “hallmark of aging,” refers to a chronic, progressive increase in the proinflammatory status of mammals as they age, and this...
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Immunosenescence and inflammaging in the aged horse
The equine population in the United States and worldwide now includes a higher percentage of geriatric horses than ever previously recorded, and as...
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Role of Inflammaging on the Reproductive Function and Pregnancy
During female lifetime and pregnancy, inflammation and cellular senescence are implicated in physiological processes, from ovulation and...
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The innate immune system in human kidney inflammaging
Elderly individuals with chronic disorders tend to develop inflammaging, a condition associated with elevated levels of blood inflammatory markers,...
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CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging
Chronic systemic inflammation is one of the hallmarks of the aging immune system. Here we show that activated T cells from older adults contribute to...
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Interplay between Inflammaging, Frailty and Nutrition in Covid-19: Preventive and Adjuvant Treatment Perspectives
As humans age, their immune system undergoes modifications, including a low-grade inflammatory status called inflammaging. These changes are...
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