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Interaction between tissue-dwelling helminth and the gut microbiota drives mucosal immunoregulation
Tissue-dwelling helminths affect billions of people around the world. They are potent manipulators of the host immune system, prominently by...
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Nanofibers for the Immunoregulation in Biomedical Applications
Despite great efforts and achievement of nanomaterials in immune-associated diseases, the selection of appropriate nanomaterials and preparation...
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NAD+ metabolism-based immunoregulation and therapeutic potential
Nicotinamide adenine dinucleotide (NAD + ) is a critical metabolite that acts as a cofactor in energy metabolism, and serves as a cosubstrate for...
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Effects of oligo-porphyran on immunological parameters related to immunoregulation and growth in RAW264.7 macrophages and zebrafish model
Many carbohydrate compounds derived from marine seaweeds possess immune-enhancing activities. In recent years, the effect of dietary addition of...
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Extracellular vesicle-mediated immunoregulation in cancer
Extracellular vesicles (EVs) have emerged as immunomodulatory regulators during tumor progression. These small vesicles encapsulate a variety of...
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Metabolite itaconate in host immunoregulation and defense
Metabolic states greatly influence functioning and differentiation of immune cells. Regulating the metabolism of immune cells can effectively...
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Inhibition of COX-2 ameliorates murine liver schistosomiasis japonica through splenic cellular immunoregulation
BackgroundWe have reported the positive association of the cyclooxygenase 2 (COX-2)/prostaglandin E2 (PGE2) axis with liver fibrosis induced by Schist...
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Electrical stimulation-based conductive hydrogel for immunoregulation, neuroregeneration and rapid angiogenesis in diabetic wound repair
Diabetic wounds are hard-healing chronic wounds, mainly caused by wound infection, excessive inflammation, diabetic neuropathy, and peripheral...
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Macrophages in immunoregulation and therapeutics
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces and are a vital part of the innate immune system for host...
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Influence of type 2 diabetes and obesity on adipose mesenchymal stem/stromal cell immunoregulation
Type 2 diabetes (T2D), associated with obesity, represents a state of metabolic inflammation and oxidative stress leading to insulin resistance and...
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Intestinal immunoregulation: lessons from human mendelian diseases
The mechanisms that maintain intestinal homeostasis despite constant exposure of the gut surface to multiple environmental antigens and to billions...
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Oligopeptide/Histidine Transporter PHT1 and PHT2 — Function, Regulation, and Pathophysiological Implications Specifically in Immunoregulation
The oligopeptide/histidine transporters PHT1 and PHT2, two mammalian solute carrier family 15A proteins, mediate the transmembrane transport of...
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Umbilical cord mesenchymal stem cells relieve osteoarthritis in rats through immunoregulation and inhibition of chondrocyte apoptosis
This study aims to investigate the effectiveness of umbilical cord mesenchymal stem cells (UCMSCs) in treating osteoarthritis (OA). Sprague–Dawley...
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Biosynthesized gold nanoparticles that activate Toll-like receptors and elicit localized light-converting hyperthermia for pleiotropic tumor immunoregulation
Manipulating the tumor immune contexture towards a more active state can result in better therapeutic outcomes. Here we describe an easily accessible...
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Lean adipose tissue macrophage derived exosome confers immunoregulation to improve wound healing in diabetes
Chronic non-healing wounds, a prevalent complication of diabetes, are associated with increased mortality in diabetic patients. Excessive...
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The landscape of immune checkpoint-related long non-coding RNAs core regulatory circuitry reveals implications for immunoregulation and immunotherapy responses
Long non-coding RNAs (lncRNAs) could modulate expression of immune checkpoints (ICPs) by cooperating with immunity genes in tumor immunization....
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The Main Mechanisms of Mesenchymal Stem Cell-Based Treatments against COVID-19
BackgroundCoronavirus disease 2019 (COVID-19) has a clinical manifestation of hypoxic respiratory failure and acute respiratory distress syndrome....
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CD155 immunoregulation as a target for natural killer cell immunotherapy in glioblastoma
Natural killer (NK) cells are powerful immune effectors, modulating their anti-tumor function through a balance activating and inhibitor ligands on...
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TC14012 enhances the anti-fibrosis effects of UC-MSCs on the liver by reducing collagen accumulation and ameliorating inflammation
BackgroundMesenchymal stem cells (MSCs) are attracting attention as a promising cell-based therapy for the treatment of liver fibrosis or cirrhosis....
