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The GSK3β/Mcl-1 axis is regulated by both FLT3-ITD and Axl and determines the apoptosis induction abilities of FLT3-ITD inhibitors
Acute myeloid leukemia (AML) patients with FLT3-ITD mutations are associated with poor prognosis. FLT3-ITD inhibitors are developed and result in...
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Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition
Internal tandem duplication mutations of FLT3 (FLT3/ITD) confer poor prognosis in AML. FLT3 tyrosine kinase inhibitors (TKIs) alone have limited and...
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NADPH oxidase mediated oxidative stress signaling in FLT3-ITD acute myeloid leukemia
The internal tandem duplication of the juxtamembrane domain of the FMS-like tyrosine kinase 3 (FLT3-ITD) is the most common genetic change in acute...
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Blockade of de novo pyrimidine biosynthesis triggers autophagic degradation of oncoprotein FLT3-ITD in acute myeloid leukemia
The internal tandem duplication of the FMS-like tyrosine kinase 3 (FLT3-ITD) is one of the most frequent genetic alterations in acute myeloid...
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ITD Sample Entropy and Probabilistic Neural Network Bearing Fault Diagnosis Model
A new fault diagnosis method based on ITD sample entropy and probabilistic neural network is proposed. Firstly, the vibration signal of the equipment...
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Ultrasensitive quantitation of FLT3-ITD mutation in patients with acute myeloid leukemia using ddPCR
BackgroundFLT3 -ITD mutations occur in 45–50% of cytogenetically normal AML patients. Conventional fragment analysis using capillary electrophoresis...
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PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia
High metabolic flexibility is pivotal for the persistence and therapy resistance of acute myeloid leukemia (AML). In 20–30% of AML patients,...
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Variabilities and trends in the onset, peak, and retreat of Intertropical Discontinuity (ITD) annual migrations over West Africa between 1979 and 2020
The study investigates variabilities and trends in the onset, peak, and retreat of Intertropical Discontinuity (ITD) annual migrations over West...
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Emerging DNA Methylome Targets in FLT3-ITD-Positive Acute Myeloid Leukemia: Combination Therapy with Clinically Approved FLT3 Inhibitors
The internal tandem duplication (ITD) mutation of the FMS-like receptor tyrosine kinase 3 ( FLT3-ITD ) is the most common mutation observed in...
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GNF-7, a novel FLT3 inhibitor, overcomes drug resistance for the treatment of FLT3‑ITD acute myeloid leukemia
BackgroundAcute myeloid leukemia (AML) with FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutation accounts for a large...
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A novel lncRNA SNHG29 regulates EP300- related histone acetylation modification and inhibits FLT3-ITD AML development
Internal tandem duplication (ITD) mutations within the FMS-like tyrosine kinase-3 (FLT3) occur in up to 25% of acute myeloid leukemia (AML) patients...
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IGF2BP2 promotes lncRNA DANCR stability mediated glycolysis and affects the progression of FLT3-ITD + acute myeloid leukemia
Internal tandem duplication (ITD) is the most common type of FLT3 mutation (FLT3-ITD), accounting for about 25% of AML patients. The expression of...
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Outcomes and prognosis of haploidentical haematopoietic stem cell transplantation in children with FLT3-ITD mutated acute myeloid leukaemia
The presence of internal tandem duplication mutations in the FMS-like tyrosine kinase 3 receptor ( FLT3-ITD ) is a poor prognostic predictor in...
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Do NPM1 and FLT3-ITD mutations modify prognosis in patients treated with non-intensive regimens?
FLT3 -ITD and NPM1 mutations are key to defining the genetic risk profile of acute myeloid leukemia (AML). We aimed to assess the prognostic features...
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Microenvironmental CXCL12 deletion enhances Flt3-ITD acute myeloid leukemia stem cell response to therapy by reducing p38 MAPK signaling
Fms-like tyrosine kinase 3 (Flt3) tyrosine kinase inhibitors (Flt3-TKI) have improved outcomes for patients with Flt3-mutated acute myeloid leukemia...
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Simvastatin Preferentially Targets FLT3/ITD Acute Myeloid Leukemia by Inhibiting MEK/ERK and p38-MAPK Signaling Pathways
BackgroundThe FLT3 /ITD mutation exists in many acute myeloid leukemia (AML) patients and is related to the poor prognosis of patients. In this...
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A Novel Method for Extracting Compound Faults Features of Rolling Bearing Based on ITD-Hjorth-TES
To solve the difficulties of extracting the fault feature information from compound failures of rolling bearings, a new method by combining intrinsic...
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Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study
Sorafenib therapy improves overall survival (OS) in patients with FLT3 internal tandem duplication (ITD) acute myeloid leukemia (AML) undergoing...
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GSK3 inhibitor suppresses cell growth and metabolic process in FLT3-ITD leukemia cells
Glycogen Synthase Kinase-3 (GSK-3) was recently implicated in the dysregulated biology of acute myeloid leukemia (AML). Low concentrations of GSK-3...
