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1. Analysis of the effects of importin α1 on the nuclear translocation of IL-1α in HeLa cells

   Interleukin-1α (IL-1α), a cytokine released by necrotic cells, causes sterile inflammation. On the other hand, IL-1α is present in the nucleus and...

   Akiko Yamada, Kiyotaka Wake, ... Masatake Asano in Scientific Reports

   Article Open access 15 January 2024
   

2. Tear levels of IL-7, IL-1α, and IL-1β may differentiate between IgG4-related disease and Sjögren’s syndrome

   We aim to assess and compare a cytokine and chemokine profile in tears from patients with IgG4-related disease (IgG4-RD) and Sjögren’s syndrome (SS),...

   Eduardo Martín-Nares, Gabriela Hernández-Molina, ... Luis Llorente in Clinical Rheumatology

   Article 11 January 2023
   

3. HIF-1α is an important regulator of IL-8 expression in human bone marrow stromal cells under hypoxic microenvironment

   The secretion of IL-8 has been found increasing for different reasons in human bone marrow stromal cells (BMSCs), resulting in poor prognosis in...

   Qiqi Huang, Ruolan You, ... Huifang Huang in Protoplasma

   Article 23 December 2023
   

4. Increased IL-1α expression in chronic rhinosinusitis with nasal polyps

   Purpose

   To examine whether and how interleukin (IL)-1α is involved in chronic rhinosinusitis with nasal polyps (CRSwNP).

   Methods

   Nasal polyp (NP) and...

   Yujie Cao, **anting Hu, ... Huabin Li in European Archives of Oto-Rhino-Laryngology

   Article Open access 27 September 2022
   

5. IL-6 regulates epithelial ovarian cancer EMT, invasion, and metastasis by modulating Let-7c and miR-200c through the STAT3/HIF-1α pathway

   Interleukin-6 (IL-6) and hypoxia-inducible factor-1α (HIF-1α) play important roles in epithelial-mesenchymal transformation (EMT) and tumor...

   Qiao Yun Guo, Jiang Nan Song, ... **ao Chen in Medical Oncology

   Article 14 May 2024
   

6. Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure

   IL-1α is an intracellular danger signal (DAMP) released by macrophages contributing to the development of silica-induced lung inflammation. The exact...

   Riccardo Leinardi, Amandine Pochet, ... François Huaux in Archives of Toxicology

   Article Open access 25 February 2023
   

7. Hypoxia and TNF-α Synergistically Induce Expression of IL-6 and IL-8 in Human Fibroblast-like Synoviocytes via Enhancing TAK1/NF-κB/HIF-1α Signaling

   Hypoxia and increased levels of inflammatory cytokines in the joints are characteristics of rheumatoid arthritis (RA). However, the effects of...

   Guofen Wang, Junsong Wang, ... **n**g Luo in Inflammation

   Article 06 January 2023
   

8. Blockade of IL-1α and IL-1β signaling by the anti-IL1RAP antibody nadunolimab (CAN04) mediates synergistic anti-tumor efficacy with chemotherapy

   IL-1α and IL-1β are both involved in several aspects of tumor biology, including tumor initiation, progression, metastasis, and not least in...

   Camilla Rydberg Millrud, Adnan Deronic, ... David Liberg in Cancer Immunology, Immunotherapy

   Article 29 August 2022
   

9. Associations between IL-1α, IL-1β, TNFα, and IL-6 variations, and susceptibility to transposition of the great arteries

   Background

   To evaluate the relationship between IL-1α -889C/T (rs1800587), IL-1β -511C > T (rs16944), TNFα -308G > A (rs1800629), TNFα -238G > A...

   Latife Atasoy Karakas, Duygu Tugrul, ... Yunus Kasim Terzi in BMC Cardiovascular Disorders

   Article Open access 19 May 2022

10. HIF-1α/IL-8 axis in hypoxic macrophages promotes esophageal cancer progression by enhancing PD-L1 expression

    Esophageal cancer (EC) is a malignancy with poor prognosis and high mortality. Hypoxic microenvironment has also been proved to be an important...

    Shuai Song, Yahui Zhang, ... Yong Cui in Cancer Gene Therapy

    Article 10 November 2022
    

11. Human T_H17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation

    It has been shown that innate immune responses can adopt adaptive properties such as memory. Whether T cells utilize innate immune signaling pathways...

    Ying-Yin Chao, Alisa Puhach, ... Christina E. Zielinski in Nature Immunology

    Article Open access 05 January 2023
    

12. CRP, IL-1α, IL-1β, and IL-6 levels and the risk of breast cancer: a two-sample Mendelian randomization study

    Epidemiological studies have reported a positive association between chronic inflammation and cancer risk. However, the causal association between...

    Yongjia Cui, Shasha Cui, ... Mengfan Zhang in Scientific Reports

    Article Open access 23 January 2024
    

13. Severe gestational diabetes mellitus in lean dams is associated with low IL-1α levels and affects the growth of the juvenile mouse offspring

    We investigated how maternal gestational diabetes (GDM) impacts the metabolic status of offspring. GDM was induced in CD1 mice consuming a fast-food...

    Lucia Mihalovičová, Veronika Kunšteková, ... Katarína Šebeková in Scientific Reports

    Article Open access 30 January 2023
    

14. IL-1α-releasing T_H17 cells live long and prosper

    Joanna R. Groom, James E. Vince in Nature Immunology

    Article 19 January 2023
    

15. Ubiquitination of ADRα1d/SerpinA1 complex stimulates hypoxia to induce gastric tumorigenesis with a combination of Helicobacter pylori and chronic stress through IL-1α

    Background

    Helicobacter pylori  ( H. pylori ) has been recognized as the class I carcinogen of gastric cancer and several studies have demonstrated that...

    Faisal Aziz, **ang Li, ... Zigang Dong in Gastric Cancer

    Article 07 May 2022
    

16. Alendronate Augments Lipid A–Induced IL-1α Release via Activation of ASC but Not Caspase-11

    Nitrogen-containing bisphosphonates (NBPs), such as alendronate (ALN), are anti-bone-resorptive drugs that have inflammatory side effects. We...

    Riyoko Tamai, Izumi Mashima, Yusuke Kiyoura in Inflammation

    Article 02 June 2021
    

17. STAT3 governs the HIF-1α response in IL-15 primed human NK cells

    Natural killer (NK) cells mediate innate host defense against microbial infection and cancer. Hypoxia and low glucose are characteristic for these...

    Anna Coulibaly, Sonia Y. Velásquez, ... Holger A. Lindner in Scientific Reports

    Article Open access 29 March 2021
    

18. Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection

    Microglia, resident immune cells of the CNS, are thought to defend against infections. Toxoplasma gondii is an opportunistic infection that can cause...

    Samantha J. Batista, Katherine M. Still, ... Tajie H. Harris in Nature Communications

    Article Open access 23 July 2020
    

19. Interleukin-1α links peripheral Ca_V2.2 channel activation to rapid adaptive increases in heat sensitivity in skin

    Neurons have the unique capacity to adapt output in response to changes in their environment. Within seconds, sensory nerve endings can become...

    Anne-Mary N. Salib, Meredith J. Crane, ... Diane Lipscombe in Scientific Reports

    Article Open access 20 April 2024
    

20. PGC-1α inhibits M2 macrophage polarization and alleviates liver fibrosis following hepatic ischemia reperfusion injury

    Oxidative stress can induce inflammation, promoting macrophage polarization and liver fibrosis following hepatic ischemia-reperfusion (I/R)....

    Yanting Zhang, Linzhong Zhang, ... **uying Zhang in Cell Death Discovery

    Article Open access 07 September 2023