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Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
WD repeat domain 5 (WDR5), an integral component of the MLL/KMT2A lysine methyltransferase complex, is critically involved in oncogenesis and...
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AIOLOS-Associated Inborn Errors of Immunity
AIOLOS, encoded by the IKZF3 gene, belongs to the Ikaros zinc finger transcription factor family and plays a pivotal role in regulating lymphocyte...
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IKZF3 amplification frequently occurs in HER2-positive breast cancer and is a potential therapeutic target
Breast cancer is one of the leading causes of cancer death in women, and although treatment outcome has substantially improved in the past decades,...
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The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes
Intestinal intraepithelial lymphocytes (IELs) exhibit prompt innate-like responses to microenvironmental cues and require strict control of effector...
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IKAROS: from chromatin organization to transcriptional elongation control
IKAROS is a master regulator of cell fate determination in lymphoid and other hematopoietic cells. This transcription factor orchestrates the...
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IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development
Ikaros transcription factors are essential for adaptive lymphocyte function, yet their role in innate lymphopoiesis is unknown. Using conditional...
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Aiolos regulates eosinophil migration into tissues
Expression of Ikaros family transcription factor IKZF3 (Aiolos) increases during murine eosinophil lineage commitment and maturation. Herein, we...
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Acoel single-cell atlas reveals expression dynamics and heterogeneity of adult pluripotent stem cells
Adult pluripotent stem cell (aPSC) populations underlie whole-body regeneration in many distantly-related animal lineages, but how the underlying...
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Mutated IKZF1 is an independent marker of adverse risk in acute myeloid leukemia
Genetic lesions of IKZF1 are frequent events and well-established markers of adverse risk in acute lymphoblastic leukemia. However, their function in...
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Mechanism and therapeutic implications of pomalidomide-induced immune surface marker upregulation in EBV-positive lymphomas
Epstein-Barr virus (EBV) downregulates immune surface markers to avoid immune recognition. Pomalidomide (Pom) was previously shown to increase immune...
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Autoimmune gene expression profiling of fingerstick whole blood in Chronic Fatigue Syndrome
BackgroundMyalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating condition that can lead to severe impairment of physical,...
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Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity
During intracellular infection, T follicular helper (T FH ) and T helper 1 (T H 1) cells promote humoral and cell-mediated responses, respectively....
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A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS
In the present study, we report a human-inherited, impaired, adaptive immunity disorder, which predominantly manifested as a B cell differentiation...
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Activity-based profiling of cullin–RING E3 networks by conformation-specific probes
The cullin–RING ubiquitin ligase (CRL) network comprises over 300 unique complexes that switch from inactive to activated conformations upon...
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Large-scale map** and mutagenesis of human transcriptional effector domains
Human gene expression is regulated by more than 2,000 transcription factors and chromatin regulators
1 ,2 . Effector domains within these proteins can...
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Inborn errors of immunity—recent advances in research on the pathogenesis
Primary immunodeficiency (PID) is a genetic disorder with a defect of one of the important components of our immune system. Classical PID has been...
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Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon
The design of cereblon-binding molecular glues (MGs) that selectively recruit a desired protein while excluding teratogenic SALL4 is an area of...
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