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Hypercapnic Chronic Obstructive Pulmonary Disorder
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. COPD refers to a chronic inflammatory lung disease that...
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Standard vs. carbone dioxide adapted kidney replacement therapy in hypercapnic ARDS patients: a randomized controlled pilot trial (BigBIC)
BackgroundCurrent continuous kidney replacement therapy (CKRT) protocols ignore physiological renal compensation for hypercapnia. This study aimed to...
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Respiratory Acidosis
In this chapter, the mechanisms of carbon dioxide balance, pathophysiology, causes, diagnosis, clinical manifestations, and management of acute and...
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Long-term outcomes in patients with COPD treated with non-invasive ventilation for acute hypercapnic respiratory failure
PurposeChronic Obstructive Lung Disease (COPD) remains a major cause of morbidity and mortality across the world. We evaluated survival over 9 years...
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High-flow nasal cannula versus non-invasive ventilation for acute hypercapnic respiratory failure in adults: a systematic review and meta-analysis of randomized trials
BackgroundNon-invasive ventilation (NIV) with bi-level positive pressure ventilation is a first-line intervention for selected patients with acute...
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Acute sodium bicarbonate administration improves ventilatory efficiency in experimental respiratory acidosis: clinical implications
Administering sodium bicarbonate (NaHCO 3 ) to patients with respiratory acidosis breathing spontaneously is contraindicated because it increases...
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Is disposable continuous positive airway pressure system effective for the management of acute hypercapnic respiratory failure?
AimThis study aimed to investigate the effectiveness of disposable continuous positive airway pressure (DCPAP) system in decreasing the partial...
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Nasal high-flow compared to non-invasive ventilation in treatment of acute acidotic hypercapnic exacerbation of chronic obstructive pulmonary disease—protocol for a randomized controlled noninferiority trial (ELVIS)
BackgroundAcute exacerbations of chronic obstructive pulmonary disease (AECOPD) have a major negative impact on health status, rates of...
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Noninvasive Ventilation in Chronic Obstructive Pulmonary Disease: Ventilating the Patient with Severe Respiratory Acidosis
Acute exacerbation of chronic obstructive lung disease (AECOPD) is leading indication for noninvasive ventilation. While coma is absolute...
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Response of TRPM2 Channel to Hypercapnic Acidosis and Role of Zn, Se, and GSH
Hypercapnia can increase the production of reactive oxygen species (ROS) by inducing oxidative stress in cells. Transient receptor potential...
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Neuroprotective Role of Acidosis in Ischemia: Review of the Preclinical Evidence
Efforts to develop effective neuroprotective therapies for ischemic stroke have had little success to date. One promising approach to neuroprotection...
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Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response
After a fortuitous observation of two cases of chemosensitivity recovery in women with congenital central hypoventilation syndrome (CCHS) who took...
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Hypercapnic Obstructive Sleep Apnea
Sleep-disordered breathing (SDB) syndromes reflect complex pathophysiological interactions between upper airway obstruction, chemoreflex control of...
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A randomised controlled trial of non-invasive ventilation compared with extracorporeal carbon dioxide removal for acute hypercapnic exacerbations of chronic obstructive pulmonary disease
BackgroundPatients presenting with acute hypercapnic respiratory failure due to exacerbations of chronic obstructive pulmonary disease (AECOPD) are...
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Clinical Case in Noninvasive Ventilation: Clinical Conditions—Hypercapnic Failure—Neuromuscular Disorders in Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis is a neuromuscular disease that affects all muscular groups with exception of extrinsic muscles of the eye and...
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Prehospital reversal of profound respiratory acidosis and hypercapnic coma by non-invasive ventilation: a report of two cases
BackgroundIn chronic obstructive pulmonary disease (COPD) patients with acute respiratory failure (ARF), non-invasive ventilation (NIV) is generally...
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Salbutamol-induced lactic acidosis in status asthmaticus survivor
BackgroundSalbutamol-induced lactic acidosis is a rare presentation that could manifest in specific clinical context as acute asthmatic attack...
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Extracorporeal carbon dioxide removal for acute respiratory failure: a review of potential indications, clinical practice and open research questions
Extracorporeal carbon dioxide removal (ECCO 2 R) is a form of extracorporeal life support (ECLS) largely aimed at removing carbon dioxide in patients...
