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LncRNA MIR181A2HG negatively regulates human keratinocytes proliferation by binding SRSF1
Psoriasis is a common chronic inflammatory skin disease. Abnormal proliferation of keratinocytes plays an important role in the pathogenesis of...
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In vitro generation of epidermal keratinocytes from human CD34-positive hematopoietic stem cells
The epidermis is largely composed of keratinocytes (KCs), and the proliferation and differentiation of KCs from the stratum basale to the stratum...
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Influence of UV nail lamps radiation on human keratinocytes viability
Ultraviolet nail lamps are becoming increasingly popular, however, the safety of their use remains controversial. The following article directly...
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Intracellular Mg2+ protects mitochondria from oxidative stress in human keratinocytes
Reactive oxygen species (ROS) are harmful for the human body, and exposure to ultraviolet irradiation triggers ROS generation. Previous studies have...
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Hesperetin activates CISD2 to attenuate senescence in human keratinocytes from an older person and rejuvenates naturally aged skin in mice
BackgroundCDGSH iron-sulfur domain-containing protein 2 (CISD2), a pro-longevity gene, mediates healthspan in mammals. CISD2 is down-regulated during...
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SOX4 reversibly induces phenotypic changes by suppressing the epithelial marker genes in human keratinocytes
BackgroundSOX4 is a transcription factor belonging to the SOX (Sry-related High Mobility Group [HMG] box) family and plays a pivotal role in various...
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Immature mandarin orange extract increases the amount of hyaluronic acid in human skin fibroblast and keratinocytes
Immature mandarin orange is thinned in order to maturation of orange. To use immature mandarin orange as a cosmetic functional material, we...
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Lipidomic assessment of the impact of Nannochloropsis oceanica microalga lipid extract on human skin keratinocytes exposed to chronic UVB radiation
Considerable attention has been devoted to investigating the biological activity of microalgal extracts, highlighting their capacity to modulate...
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Green cocoon-derived sericin reduces cellular damage caused by radiation in human keratinocytes
Radiation therapy used in the treatment of cancer causes skin damage, and no method of care has been established thus far. Recently, it has become...
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Characterisation of cytotoxicity and immunomodulatory effects of glycolipid biosurfactants on human keratinocytes
AbstractSkin irritation and allergic reactions associated with the use of skincare products formulated with synthetically derived surfactants such as...
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Human-Induced Pluripotent Stem Cell‒Derived Keratinocytes, as Therapeutic Option in Vitiligo
Vitiligo is a skin condition affecting 1% of the global population, causing non-scaly, chalky-white macules on the skin and hair. It is caused by the...
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Efficient Generation of CRISPR/Cas9-Mediated Knockout Human Primary Keratinocytes by Electroporation
Due to their full differentiation capacity in vitro, the culture of human primary keratinocytes (HPKs) represents a physiological model for answering...
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Cellular response of keratinocytes to the entry and accumulation of nanoplastic particles
Plastic accumulation in the environment is rapidly increasing, and nanoplastics (NP), byproducts of environmental weathering of bulk plastic waste,...
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Molecular mechanism of the anti-inflammatory and skin protective effects of Syzygium formosum in human skin keratinocytes
Irradiation injury, especially caused by UVB, of the skin is one of the critical reasons for skin inflammation and damage. The present study aimed to...
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Cathepsin F is a potential marker for senescent human skin fibroblasts and keratinocytes associated with skin aging
Cellular senescence is characterized by cell cycle arrest and the senescence-associated secretory phenotype (SASP) and can be triggered by a variety...
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Exosomes from human induced pluripotent stem cells-derived keratinocytes accelerate burn wound healing through miR-762 mediated promotion of keratinocytes and endothelial cells migration
BackgroundThe use of keratinocytes derived from induced pluripotent stem cells (iPSCs-KCs) may represent a novel cell therapy strategy for burn...
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HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes
Formation and maintenance of skin barrier function require tightly controlled membrane-associated proteolysis, in which the integral membrane...
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Porcine placental extract increase the cellular NAD levels in human epidermal keratinocytes
Nicotinamide adenine dinucleotide (NAD) is an essential cofactor for numerous enzymes involved in energy metabolism. Because decreasing NAD levels is...
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PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes
AbstractPoly(ADP-ribose) polymerase 2 (PARP2) alongside PARP1 are responsible for the bulk of cellular PARP activity, and they were first described...
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Anti-inflammatory effect of taxifolin in TNF-α/IL-17A/IFN-γ induced HaCaT human keratinocytes
Taxifolin, a bioactive flavonoid, has been attracting attention as a beneficial and valuable phytochemical due to its antioxidant, anticancer, and...
