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1. Hsa_circ_0031891 targets miR-579-3p to enhance HMGB1 expression and regulate PDGF-BB-induced human aortic vascular smooth muscle cell proliferation, migration, and dedifferentiation

   Atherosclerosis (AS) is an underlying cause of the majority of coronary artery disease (CAD), in which proliferation, migration, and...

   Long Wang, Huacheng Li, ... Yongxiang Li in Naunyn-Schmiedeberg's Archives of Pharmacology

   Article 22 August 2023
   

2. Inhibitory Activities of GDX-365 on HMGB1-mediated Septic Responses

   GDX-365, is the main fraction of black ginseng comprising protopanaxatriol-type rare ginsenosides (ginsenosides Rg3, Rk1, and Rg5). High mobility...

   Dong-Hyuk Baek, Go Oun Kim, ... Jong-Sup Bae in Biotechnology and Bioprocess Engineering

   Article 21 June 2023

3. SYVN1 modulates papillary thyroid carcinoma progression by destabilizing HMGB1

   E3 ubiquitin ligase synoviolin (SYVN1) has been reported to participate in many human cancers. This study aimed to investigate SYVN1’s roles and...

   Fei Duan, Fanli Kong, ... Hongbing Liu in Cell Division

   Article Open access 28 April 2024
   

4. HMGB1/SET/HAT1 complex-mediated SASH1 repression drives glycolysis and metastasis in lung adenocarcinoma

   High-mobility group box 1 (HMGB1) can enhance the stability and accessibility of nucleus binding sites to nucleosomes and transcription factors....

   Fan Kou, Lei Wu, ... Lili Yang in Oncogene

   Article 04 October 2023
   

5. NMDARs activation regulates endothelial ferroptosis via the PP2A-AMPK-HMGB1 axis

   N-methyl-D-aspartate receptors (NMDARs) are ligand-gated, voltage-dependent channels of the ionotropic glutamate receptor family. The present study...

   Wei-Min Han, Yi-**ang Hong, ... Gang Li in Cell Death Discovery

   Article Open access 17 January 2024
   

6. The multifunctional protein HMGB1: 50 years of discovery

   Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin, HMGB1 is now known to regulate diverse biological...

   Daolin Tang, Rui Kang, ... Michael T. Lotze in Nature Reviews Immunology

   Article 15 June 2023
   

7. HMGB1: A New Target for Ischemic Stroke and Hemorrhagic Transformation

   Stroke in China is distinguished by its high rates of morbidity, recurrence, disability, and mortality. The ultra-early administration of rtPA is...

   Jiamin Li, Zixin Wang, ... Qingfeng Ma in Translational Stroke Research

   Article Open access 14 May 2024
   

8. High Mobility Group Box Protein (HMGB1): A Potential Therapeutic Target for Diabetic Encephalopathy

   HMGB (high mobility group B) is one of the ubiquitous non-histone nuclear protein superfamilies that make up the HMG (high mobility group) protein...

   Udit Kumar Dash, Debashree Mazumdar, Santosh Singh in Molecular Neurobiology

   Article 13 March 2024
   

9. HMGB1 May Modulates Proliferation and Migration of Endothelial Cells by YAP1 under Hypoxia

   Abstract

   Endothelial dysfunction is a key factor in the occurrence of coronary artery disease and plays a vital role in the pathological development...

   Liu Weiwei, Wang Yan, ... Shi Bei in Biology Bulletin

   Article 09 February 2024
   

10. HMGB1 prefers to interact with structural RNAs and regulates rRNA methylation modification and translation in HeLa cells

    Background

    High-mobility group B1 (HMGB1) is both a DNA binding nuclear factor modulating transcription and a crucial cytokine that mediates the...

    Meimei Liao, Jiarui Cao, ... Sen Chen in BMC Genomics

    Article Open access 05 April 2024
    

11. IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development

    Background

    IGF2BP3 functions as an RNA-binding protein (RBP) and plays a role in the posttranscriptional control of mRNA localization, stability, and...

    Lei Lv, Qinqin Wei, ... Qiyi Yi in Cellular & Molecular Biology Letters

    Article Open access 19 March 2024
    

12. HMGB1 promotes mitochondrial transfer between hepatocellular carcinoma cells through RHOT1 and RAC1 under hypoxia

    Mitochondrial transfer plays an important role in various diseases, and many mitochondrial biological functions can be regulated by HMGB1. To explore...

    Mengjia **g, **aofeng **ong, ... Wei Yan in Cell Death & Disease

    Article Open access 20 February 2024
    

13. HMGB1 and Toll-like receptors: potential therapeutic targets in autoimmune diseases

    HMGB1, a nucleoprotein, is expressed in almost all eukaryotic cells. During cell activation and cell death, HMGB1 can function as an alarm protein...

    Wenxuan Ren, Lei Zhao, ... **aoguang Shi in Molecular Medicine

    Article Open access 04 September 2023
    

14. Effects of metformin therapy on HMGB1 levels in rheumatoid arthritis patients

    Objective

    The traditional treatment of rheumatoid arthritis (RA) has some side effects. We aimed to explore the effect of metformin treatment on the...

    Lihua Zhang, Yuqing Zhou, ... Lingyun Huang in European Journal of Medical Research

    Article Open access 15 November 2023
    

15. The Association of HMGB1 and RAGE Gene Polymorphisms with IgA Vasculitis

    High-mobility group box 1 (HMGB1) is a pleiotropic cytokine that propagates inflammation by its extracellular action of interacting with the receptor...

    Mateja Batnozic Varga, Martina Held, ... Marija Jelusic in Biochemical Genetics

    Article 30 October 2023

16. SHARPIN contributes to sevoflurane-induced neonatal neurotoxicity through up-regulating HMGB1 to repress M2 like-macrophage polarization

    Sevoflurane exposure can result in neurotoxicity especially among children, which remains an important complication after surgery. However, its...

    Junying Cai, Yue Lin, ... Jun Lu in Metabolic Brain Disease

    Article 28 May 2024
    

17. NRF2 transcriptionally regulates Caspase-11 expression to activate HMGB1 release by Autophagy-deficient hepatocytes

    Injury or stress can induce intracellular translocation and release of nuclear HMGB1, a DAMP molecule known to participate in inflammation and other...

    Bilon Khambu, Genxiang Cai, ... **ao-Ming Yin in Cell Death Discovery

    Article Open access 28 July 2023
    

18. Hsa_circ_0007292 promotes chondrocyte injury in osteoarthritis via targeting the miR-1179/HMGB1 axis

    Background

    Circular RNAs (circRNAs) have been demonstrated to participate in the progression of osteoarthritis (OA). This study aimed to investigate...

    Zhi** Lin, Peng Li, ... Lianxiang Luo in Journal of Orthopaedic Surgery and Research

    Article Open access 29 July 2023
    

19. Promoting AMPK/SR-A1-mediated clearance of HMGB1 attenuates chemotherapy-induced peripheral neuropathy

    Background

    Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect of chemotherapy with poorly understood mechanisms and few...

    **ng Yang, Rumeng Jia, ... Wen-Tao Liu in Cell Communication and Signaling

    Article Open access 04 May 2023
    

20. USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity

    Background

    High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) molecule that plays a central role in innate immunity....

    Jaemin Shin, Young Hun Kim, ... Jeon-Soo Shin in Molecular Medicine

    Article Open access 30 December 2022