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Primary Human Nasal Epithelial Cell Culture
Primary human nasal epithelial cell (HNEC) cultures serve as an excellent model in studying physiology, disease, and therapy related to the...
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Single Cell Atlas: a single-cell multi-omics human cell encyclopedia
Single-cell sequencing datasets are key in biology and medicine for unraveling insights into heterogeneous cell populations with unprecedented...
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Emerging Human Pluripotent Stem Cell-Based Human–Animal Brain Chimeras for Advancing Disease Modeling and Cell Therapy for Neurological Disorders
Human pluripotent stem cell (hPSC) models provide unprecedented opportunities to study human neurological disorders by recapitulating human-specific...
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Single cell multi-omics reveal intra-cell-line heterogeneity across human cancer cell lines
Human cancer cell lines have long served as tools for cancer research and drug discovery, but the presence and the source of intra-cell-line...
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High-dimensional single-cell analysis of human natural killer cell heterogeneity
Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to microbes and tumors. Historically, their...
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A single-cell chromatin accessibility dataset of human primed and naïve pluripotent stem cell-derived teratoma
Teratoma, due to its remarkable ability to differentiate into multiple cell lineages, is a valuable model for studying human embryonic development....
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Single-cell transcriptome analysis reveals secretin as a hallmark of human enteroendocrine cell maturation
The traditional nomenclature of enteroendocrine cells (EECs), established in 1977, applied the “one cell - one hormone” dogma, which distinguishes...
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TLR9 agonism differentially impacts human NK cell-mediated direct killing and antibody-dependent cell-mediated cytotoxicity
There are two known mechanisms by which natural killer (NK) cells recognize and kill diseased targets: (i) direct killing and (ii) antibody-dependent...
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Deciphering cell states and genealogies of human haematopoiesis
The human blood system is maintained through the differentiation and massive amplification of a limited number of long-lived haematopoietic stem...
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Retroviral Transduction of Human Primary T Cells Followed by Real-Time T-Cell-Mediated Cancer Cell Cytolysis Analysis
Retroviral transduction is a highly useful tool to genetically engineer hard-to-transfect human primary cells. Here, we transduce human primary T...
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Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial metabolites through a semi-invariant T cell receptor...
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Large-scale neurophysiology and single-cell profiling in human neuroscience
Advances in large-scale single-unit human neurophysiology, single-cell RNA sequencing, spatial transcriptomics and long-term ex vivo tissue culture...
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A human stomach cell type transcriptome atlas
BackgroundThe identification of cell type-specific genes and their modification under different conditions is central to our understanding of human...
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Human myofibroblasts increase the arrhythmogenic potential of human induced pluripotent stem cell-derived cardiomyocytes
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have the potential to remuscularize infarcted hearts but their...
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EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous cell carcinoma
Lymph node metastasis, primarily caused by the migration of oral squamous cell carcinoma (OSCC) cells, stands as a crucial prognostic marker. We have...
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Human Primordial Germ Cell-Like Cell Induction from Pluripotent Stem Cells by SOX17 and PRDM1 Expression
Human primordial germ cell (PGC) development initiates about 2 weeks after fertilization during embryogenesis. Unique molecular events follow,...
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Human placental extract suppresses mast cell activation and induces mast cell apoptosis
BackgroundHuman placental extract (HPE) has been documented to facilitate the healing of certain disorders including allergy. However, the effects of...
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The broad impact of cell death genes on the human disease phenome
Cell death mediated by genetically defined signaling pathways influences the health and dynamics of all tissues, however the tissue specificity of...
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A roadmap for delivering a human musculoskeletal cell atlas
Advances in single-cell technologies have transformed the ability to identify the individual cell types present within tissues and organs. The...
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Dissecting the human leptomeninges at single-cell resolution
Emerging evidence shows that the meninges conduct essential immune surveillance and immune defense at the brain border, and the dysfunction of...
