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Specification of Hsp70 Function by Hsp40 Co-chaperones
Cellular homeostasis and stress survival requires maintenance of the proteome and suppression of proteotoxicity. Molecular chaperones promote cell...
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HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC), the most prevalent type of pancreatic cancer, is one of the deadliest forms of cancer with limited therapy...
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Ectopic BH3-Only Protein Bim Associates with Hsp70 to Regulate Yeast Mitophagy
AbstractMitophagy, a form of selective autophagy, plays an essential role to maintain a population of healthy and functional mitochondria for normal...
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DNAJB6 mutants display toxic gain of function through unregulated interaction with Hsp70 chaperones
Molecular chaperones are essential cellular components that aid in protein folding and preventing the abnormal aggregation of disease-associated...
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An Hsp70 promoter–based mouse for heat shock–induced gene modulation
AbstractPhysical therapy is extensively employed in clinical settings. Nevertheless, the absence of suitable animal models has resulted in an...
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HSP70-HSP90 Chaperone Networking in Protein-Misfolding Disease
Molecular chaperones and their associated co-chaperones are essential in health and disease as they are key facilitators of protein-folding, quality...
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Autocrine regulation of tumor cell repopulation by Hsp70-HMGB1 alarmin complex
BackgroundCancer recurrence is regulated by a variety of factors, among which is the material of dying tumor cells; it is suggested that remaining...
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Effect of Microwave Ablation on HSP70 Expression in Papillary Thyroid Microcarcinoma: A Preliminary Study
To explore the changes of Heat Shock Protein 70 (HSP70) expression after microwave ablation (MWA) of papillary thyroid microcarcinoma (PTMC) and to...
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Exploring the binding mechanism of a small molecular Hsp70-Bim PPI inhibitor through molecular dynamic simulation
ContextThe interface of Hsp70-Bim protein–protein interaction (PPI) has been identified as a specific target for Chronic Myeloid Leukemia (CML)...
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HSP70 attenuates neuronal necroptosis through the HSP90α-RIPK3 pathway following neuronal trauma
BackgroundNecroptosis, a newly defined regulatable necrosis with membrane disruption, has been demonstrated to participate in trauma brain injury...
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A new look at Hsp70 activity in phosphatidylserine-enriched membranes: chaperone-induced quasi-interdigitated lipid phase
70 kDa heat shock protein Hsp70 (also termed HSP70A1A) is the major stress-inducible member of the HSP70 chaperone family, which is present on the...
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Cell-Permeable HSP70 Protects Neurons and Astrocytes Against Cell Death in the Rotenone-Induced and Familial Models of Parkinson’s Disease
Heat shock protein 70 (HSP70) is activated under stress response. Its involvement in cell protection, including energy metabolism and quality control...
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X-ray reflectivity study of the heat shock protein Hsp70 interaction with an artificial cell membrane model
Membrane-bound heat shock protein 70 (Hsp70) apart from its intracellular localization was shown to be specifically expressed on the plasma membrane...
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Hsp70 Knockdown in the Brine Shrimp Artemia franciscana: Implication on Reproduction, Immune Response and Embryonic Cuticular Structure
The potential functional role(s) of heat shock protein 70 (Hsp70) in the brine shrimp, Artemia franciscana , a crucial crustacean species for...
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HSP70 protects PC12 cells against TBHP-induced apoptosis and oxidative stress by activating the Nrf2/HO-1 signaling pathway
HSP70 exhibits neuroprotective, antioxidant, and anti-apoptotic properties, which are crucial in preventing spinal cord injury (SCI) induced by...
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Hsp70-Bim interaction facilitates mitophagy by recruiting parkin and TOMM20 into a complex
BackgroundFor cancer therapy, the identification of both selective autophagy targets and small molecules that specifically regulate autophagy is...
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Relationship between intrathrombotic appearance of HSP27 and HSP70 and thrombus ages in a murine model of deep vein thrombosis
Heat shock proteins (HSPs) are molecular chaperones whose primary function is cytoprotection, supporting cell survival under (sub) lethal conditions....
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A molecular docking study between heavy metals and hydrophilic Hsp70 protein to explore binding pockets
Microorganisms are abundant in whole biosphere and exert influential activities on numerous biological phenomena. The source of heavy metal...
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Sensitive detection of HSP70 using a current-amplified biosensor based on antibody-loaded PS-AuNPs@Cys/Au modified ITO chip
A biosensing electrochemical platform for heat shock protein 70 (HSP70) has been developed by integrating a three-electrode indium tin oxide (ITO) on...
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Small molecule inhibitor targeting the Hsp70-Bim protein–protein interaction in estrogen receptor-positive breast cancer overcomes tamoxifen resistance
IntroductionEstrogen receptor (ER) positive patients compromise about 70% of breast cancers. Tamoxifen, an antagonist of ERα66 (the classic ER), is...
