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Tasquinimod efficacy and S100A9 expression in glucose-treated HREC cells
PurposeDiabetic retinopathy (DR) is one of the leading causes of blindness in working-aged people. Few studies were on the relationship between S100...
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Evidence-Based Guidelines for Low-Risk Ethics Applicants: A Qualitative Analysis of the Most Frequent Feedback Made by Human Research Ethics Proposal Reviewers
Human Research Ethics Committee (HREC) reviewers often provide similar feedback across applications, which suggests that the problem lies in...
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Human research ethics committees members: ethical review personal perceptions
This study aims to characterise Human Research Ethics Committee (HREC) members’ perceptions on five main themes associated with ethics reviews,...
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Australian human research ethics committee members’ confidence in reviewing genomic research applications
Human research ethics committees (HRECs) are evaluating increasing quantities of genomic research applications with complex ethical considerations....
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Ethical concerns in suicide research: thematic analysis of the views of human research ethics committees in Australia
BackgroundSuicide research aims to contribute to a better understanding of suicidal behaviour and its prevention. However, there are many ethical...
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Notch signaling regulates UNC5B to suppress endothelial proliferation, migration, junction activity, and retinal plexus branching
Notch signaling guides vascular development and function by regulating diverse endothelial cell behaviors, including migration, proliferation,...
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Keratoconus International Consortium (KIC)- advancing keratoconus research
Clinical relevanceThe Keratoconus International Consortium (KIC) will allow better understanding of keratoconus.
BackgroundKeratoconus is a disorder...
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Endomucin selectively regulates vascular endothelial growth factor receptor-2 endocytosis through its interaction with AP2
The endothelial glycocalyx, located at the luminal surface of the endothelium, plays an important role in the regulation of leukocyte adhesion,...
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The effect of a parental preparation video (Take5) on child and parent anxiety during anaesthetic induction: a protocol for a randomised controlled trial
BackgroundChildren undergoing anaesthetic induction experience peri-operative anxiety associated with negative outcomes including emergence delirium,...
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Focussing on Research
This chapter examines how public sector bodies go about conducting criminological research. At the outset, it considers how research topics are...
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Cholesterol crystal formation is a unifying pathogenic mechanism in the development of diabetic retinopathy
Aims/hypothesisHyper-reflective crystalline deposits found in retinal lesions have been suggested to predict the progression of diabetic retinopathy,...
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When to Suspend Bioethical Principles in Military Medicine for Operational Purposes: A Framework Approach
Occasionally in the military, operational situations arise where it is necessary to consider giving to military personnel not-yet-approved...
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Personalising genetic counselling (POETIC) trial: Protocol for a hybrid type II effectiveness-implementation randomised clinical trial of a patient screening tool to improve patient empowerment after cancer genetic counselling
BackgroundGenetic counselling aims to identify, and address, patient needs while facilitating informed decision-making about genetic testing and...
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SLC26A9 promotes colorectal tumorigenesis by modulating Wnt/β-catenin signaling
Solute carrier family 26 member 9 (SLC26A9) is a member of the Slc26a family of multifunctional anion transporters that functions as a Cl - channel in...
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A multicentre neonatal interventional randomised controlled trial of nebulized surfactant for preterm infants with respiratory distress: Neo-INSPIRe trial protocol
IntroductionRespiratory distress syndrome in preterm infants is an important cause of morbidity and mortality. Less invasive methods of surfactant...
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ZOom Delivered Intervention Against Cognitive decline (ZODIAC) COVID-19 pandemic adaptations to the Post-Ischaemic Stroke Cardiovascular Exercise Study (PISCES): protocol for a randomised controlled trial of remotely delivered fitness training for brain health
BackgroundStroke increases subsequent dementia risk yet there are no specific post-stroke therapies to protect cognition. Cardiorespiratory exercise...
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Experiences of Boosting Inpatient Exercise After HipFracture Surgery Using An Alternative Workforce - A Qualitative Study
BackgroundThrice-daily physiotherapy immediately following surgical repair of hip fracture has been shown to be safe and to reduce total hospital...
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Artificial Intelligence (AI) for Early Detection of Depression Using Machine Learning
Depression is a common mood disorder that is usually characterized by sadness, loss of interest, guilt, or low self–worth. It is associated with...
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Ultrasound-guided supraclavicular block versus Bier block for emergency reduction of upper limb injuries: a protocol for an open-label, non-inferiority, randomised controlled trial
BackgroundClosed reduction of upper limb fractures and/or dislocations are common in the emergency department (ED), which involves physically...
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Blue light exposure collapses the inner blood-retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17
Blue light is part of the natural light spectrum that emits high energy. Currently, people are frequently exposed to blue light from 3C devices,...
