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The usefulness of [68 Ga]Ga-DOTA-JR11 PET/CT in patients with meningioma: comparison with MRI
PurposeClinical studies of PET imaging using SSTR2 agonists have demonstrated high accuracy and correlation with SSTR2 expression in meningiomas....
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Synthesis, preclinical evaluation, and a pilot clinical imaging study of [18F]AlF-NOTA-JR11 for neuroendocrine neoplasms compared with [68Ga]Ga-DOTA-TATE
PurposeA [ 18 F]AlF-labeled somatostatin receptor (SSTR) antagonist was developed for imaging of neuroendocrine neoplasms (NENs), evaluated and...
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Gallium-68 labeled somatostatin receptor antagonist PET/CT in over 500 patients with neuroendocrine neoplasms: experience from a single center in China
PurposeSomatostatin receptor antagonists have shown promising performance for imaging neuroendocrine neoplasms. However, there is a lack of studies...
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Comparison of 68Ga-DOTA-JR11 PET/CT with dosimetric 177Lu-satoreotide tetraxetan (177Lu-DOTA-JR11) SPECT/CT in patients with metastatic neuroendocrine tumors undergoing peptide receptor radionuclide therapy
PurposePaired imaging/therapy with radiolabeled somatostatin receptor (SSTR) antagonists is a novel approach in neuroendocrine tumors (NETs). The aim...
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Autoradiographical assessment of inflammation-targeting radioligands for atherosclerosis imaging: potential for plaque phenotype identification
PurposeMany radioligands have been developed for the visualization of atherosclerosis by targeting inflammation. However, interpretation of in vivo...
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Theranostics with Somatostatin Receptor Antagonists
Somatostatin receptors (SST), especially SST subtype 2 (SST2), are important targets for the management of patients with neuroendocrine tumours... -
Case Study #6: [177Lu]Lu-DOTA-JR11: A Somatostatin Receptor Subtype 2 Antagonist for Radiopharmaceutical Therapy
Peptide receptor radionuclide therapy (PRRT) is a special type of radiopharmaceutical therapy (RPT) that employs peptide-based radiopharmaceuticals... -
Radionuclide Theranostics in Neuroendocrine Neoplasms: An Update
Purpose of ReviewThis paper aims to address the latest findings in neuroendocrine tumor (NET) theranostics, focusing on new evidence and future...
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Theranostics in Neuroendocrine Tumors
Neuroendocrine neoplasms (NENs) are a heterogeneous group of epithelial neoplastic proliferations ranging from indolent well differentiated... -
Theranostic Imaging and Radiopharmaceutical Therapy
The over-arching concept of “theranostics” has been described by various groups (Bodei et al., Nat Rev Clin Oncol 19:534–550, 2022, Baum and... -
Highlight selection of radiochemistry and radiopharmacy developments by editorial board
BackgroundThe Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in...
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Evaluation of the safety, biodistribution, dosimetry of [18F]AlF-NOTA-LM3 and head-to-head comparison with [68Ga]Ga-DOTATATE in patients with well-differentiated neuroendocrine tumors: an interim analysis of a prospective trial
Purpose18 F-labelled somatostatin receptor (SSTR) analogs offer several advantages over 68 Ga in terms of yield, cost, spatial resolution and...
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Design of Radiolabeled Peptide Radiopharmaceuticals
Peptides are short chains of amino acids (AA) containing less than 40–50 AAs. Twenty AAs appear in the genetic code and are considered as “standard”... -
New PET Radiotracers for the Imaging of Neuroendocrine Neoplasms
Neuroendocrine neoplasms (NEN) are a heterogeneous group of tumours derived from cells of neuroendocrine origin and can potentially arise everywhere...
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Molecular Imaging Platform and Radiopharmaceutical Translational Research on Peking University Cancer Hospital
On August 27, 2019, the signing ceremony for the cooperation between Peking University Cancer Hospital (PKUCH) and the International Centers for... -
Perspektiven der PET-Radiopharmaka und Bildgebung: Von FDG bis FAPi, vom PETScanner zum digitalen Ganzkörpertool
Die Komplexität der PET/CT, welche sich sowohl aus den gerätetechnischen Parametern eines Hybridverfahrens, aber auch aus den zum Einsatz kommenden... -
A prospective randomized, double-blind study to evaluate the diagnostic efficacy of 68Ga-NODAGA-LM3 and 68Ga-DOTA-LM3 in patients with well-differentiated neuroendocrine tumors: compared with 68Ga-DOTATATE
PurposeThe purpose of this study is to evaluate the diagnostic efficacy of 68 Ga-NODAGA-LM3 and 68 Ga-DOTA-LM3 and compare them with 68 Ga-DOTATATE...
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Biodistribution and radiation dose estimates for 68Ga-DOTA-JR11 in patients with metastatic neuroendocrine tumors
PurposeSomatostatin receptor antagonists have shown promise for imaging neuroendocrine tumors (NETs) in preclinical studies, but clinical data is...
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Peptides as Vectors for Radiopharmaceutical Therapy
Radiolabeled receptor-binding peptides enable the selective delivery of radionuclides to target tissues (e.g., tumor) while reducing radiation... -
Molecular Imaging in Oncology
Radioisotope-based molecular imaging (MI) techniques such as PET/CT and SPECT/CT aim to integrate patient-specific and disease-specific molecular...