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Unraveling the glycosylated immunopeptidome with HLA-Glyco
Recent interest in targeted therapies has been sparked by the study of MHC-associated peptides (MAPs) that undergo post-translational modifications...
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Green synthesis of glyco-CuInS2 QDs with visible/NIR dual emission for 3D multicellular tumor spheroid and in vivo imaging
Glyco-quantum dots (glyco-QDs) have attracted significant interest in bioimaging applications, notably in cancer imaging, because they effectively...
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Emerging glyco-risk prediction model to forecast response to immune checkpoint inhibitors in colorectal cancer
BackgroundAberrant glycosylation is one of the most common post-translational modifications leading to heterogeneity in colorectal cancer (CRC). This...
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“Glyco-sulfo barcodes” regulate chemokine receptor function
Chemokine ligands and receptors regulate the directional migration of leukocytes. Post-translational modifications of chemokine receptors including...
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Glyco-Decipher enables glycan database-independent peptide matching and in-depth characterization of site-specific N-glycosylation
Glycopeptides with unusual glycans or poor peptide backbone fragmentation in tandem mass spectrometry are unaccounted for in typical site-specific...
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Glyco-conjugated metal–organic framework biosensor for fluorescent detection of bacteria
Metal–organic frameworks (MOFs) are hybrid materials constructed by the linkage between an inorganic secondary building unit and an organic linker. A...
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Reaction of Tetrahydropyrimidine-2(1H)-thione Derivatives with Thiolated Acid Hydrazides as a Method of Synthesis of Biologically Active Ligands for Glyco-Gold Nanoparticles
AbstractThe reaction of 4-hydroxy-1-phenyl-6-methyltetrahydropyrimidine-2(1 H )-thione with 6-sulfanylhexanoic and lipoic (thioctic) acid hydrazides...
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Formation of a glyco-functionalized interface on polyethylene using a side-chain crystalline block copolymer with epoxide
A side-chain crystalline block copolymer was applied for the chemical modification of polyethylene surfaces. A block copolymer with stearyl and epoxy...
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Single-molecule imaging of glycan–lectin interactions on cells with Glyco-PAINT
Most lectins bind carbohydrate ligands with relatively low affinity, making the identification of optimal ligands challenging. Here we introduce a...
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Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies with a 5-year survival rate of only 9%. Despite the fact that...
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New glyco-copolymers containing α-D-glucofuranose and α-D-mannofuranose groups synthesized by free-radical polymerization of sugar-based monomers
Carbohydrates are safe materials with the potential of application in various areas, hence, in recent years, a growing interest has been attracted to...
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Functional glyco-metagenomics elucidates the role of glycan-related genes in environments
BackgroundGlycan-related genes play a fundamental role in various processes for energy acquisition and homeostasis maintenance while adapting to the...
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Synthesis of glyco-gold nanoparticles stabilized with non-thioled disaccharides
Gold nanoparticles have been used in diagnosis and treatment of several diseases; for this purpose, they must be biocompatible and easy...
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Systems glycobiology for discovering drug targets, biomarkers, and rational designs for glyco-immunotherapy
Cancer immunotherapy has revolutionized treatment and led to an unprecedented wave of immuno-oncology research during the past two decades. In 2018,...
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Fast and comprehensive N- and O-glycoproteomics analysis with MSFragger-Glyco
Recent advances in methods for enrichment and mass spectrometric analysis of intact glycopeptides have produced large-scale glycoproteomics datasets,...
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Glyco-engineered MDCK cells display preferred receptors of H3N2 influenza absent in eggs used for vaccines
Evolution of human H3N2 influenza viruses driven by immune selection has narrowed the receptor specificity of the hemagglutinin (HA) to a restricted...
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Glyco-binding domain chimeric antigen receptors as a new option for cancer immunotherapy
In the last decade, treatment using Chimeric Antigen Receptor (CAR) are largely studied and demonstrate the potential of immunotherapeutic...
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40 years of glyco-polyacrylamide in glycobiology
Polyacrylamide conjugates of glycans have long been widely used in many research areas of glycobiology, mainly for immobilizing glycans in...
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Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation
GDF15 is a distant TGF-β family member that induces anorexia and weight loss. Due to its function, GDF15 has attracted attention as a potential...
