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Comparison of Octreotide and Vasopressors as First-Line Treatment for Intraoperative Carcinoid Crisis
BackgroundIntraoperative carcinoid crisis is typically sudden onset of profound hypotension during operations on patients with neuroendocrine tumors....
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Which first-line treatment for cutaneous sarcoidosis? A retrospective study of 120 patients
BackgroundSarcoidosis is a systemic disease that affects the skin in about 25% of patients. The treatment of cutaneous sarcoidosis is guided by the...
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Immunotherapy for metastatic melanoma—from little benefit to first-line treatment
At the turn of the past century, unresectable metastatic melanoma was primarily treated with different chemotherapeutic agents, such as dacarbazine,...
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Should IUI replace IVF as first-line treatment for unexplained infertility? A literature review
BackgroundUnexplained infertility accounts for 25% of infertility causes in the UK. Active intervention methods, such as intrauterine insemination...
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Multi-omics analysis of multiple myeloma patients with differential response to first-line treatment
The genome backgrounds of multiple myeloma (MM) would affect the efficacy of specific treatment. However, the mutational and transcriptional...
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Effectiveness of first-line anticancer treatment may predict treatment response in further lines in stage III/IV patients with non-small cell lung cancer
PurposeThe aim of our study was to evaluate if therapeutic success in the first-line of anticancer treatments in patients with NSCLC may predict...
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Cost-Effectiveness of Vedolizumab as a First-Line Advanced Therapy Versus Adalimumab Treatment Sequences for Ulcerative Colitis in Italy
BackgroundToday, there are many treatment options available for the management of ulcerative colitis, creating challenges in selecting the most...
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Evolving Role of CAR T Cell Therapy in First- and Second-Line Treatment of Large B Cell Lymphoma
Purpose of ReviewWe review the recent practice-changing trials of anti-CD19 chimeric antigen receptor (CAR) T cell therapies in large B cell lymphoma...
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Dolutegravir-associated resistance mutations after first-line treatment failure in Brazil
BackgroundSince January 2017, the recommended first-line antiretroviral regimen in Brazil is the fixed-dose combination of tenofovir plus lamivudine...
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First-Line Systemic Treatment Options for Advanced Renal Cell Carcinoma
The treatment of advanced clear cell renal cell carcinoma (ccRCC) has undergone significant changes over the last two decades, particularly with the...
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Pyrotinib plus docetaxel as first-line treatment for HER2-positive metastatic breast cancer: the PANDORA phase II trial
The role of pyrotinib in the treatment of HER2-positive metastatic breast cancer (MBC) has been well-established. This multicenter, single-arm phase...
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Association between HIV and acquisition of rifamycin resistance with first-line TB treatment: a systematic review and meta-analysis
BackgroundMulti-drug or rifamycin-resistant tuberculosis (MDR/RR-TB) is an important public health concern, including in settings with high HIV...
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Systematic literature review of real-world evidence for treatments in HR+/HER2- second-line LABC/mBC after first-line treatment with CDK4/6i
BackgroundCyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) combined with endocrine therapy (ET) are currently recommended by the National...
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Non-response to first-line hormonal treatment for symptomatic endometriosis: overcoming tunnel vision. A narrative review
One-fourth to one-third of women with endometriosis receiving first-line hormonal treatment lacks an adequate response in terms of resolution of...
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Exploration of efficacy of different therapy regimens for advanced NSCLC patients with KRAS mutation in the first-line treatment
PurposeThe treatment of the advanced non-small cell lung cancer (NSCLC) with KRAS mutation has been closely paid more attention. The aim of this...
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Deep learning based digital pathology for predicting treatment response to first-line PD-1 blockade in advanced gastric cancer
BackgroundAdvanced unresectable gastric cancer (GC) patients were previously treated with chemotherapy alone as the first-line therapy. However, with...
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Prognosis and treatment pattern of advanced hepatocellular carcinoma after failure of first-line atezolizumab and bevacizumab treatment
BackgroundThe combination of atezolizumab and bevacizumab (Atezo-Bev) has become the standard first-line therapy for patients with advanced...
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Superior Efficacy of Infliximab Versus Adalimumab for First-Line Treatment of Crohn’s Perianal Fistulae
BackgroundCrohn’s disease perianal fistulae (CD-PAF) occur in 25% of patients and are notoriously challenging to manage. Tumor necrosis factor...
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Treatment Patterns in US Patients Receiving First-Line and Second-Line Therapy for Metastatic Pancreatic Ductal Adenocarcinoma in the Real World
IntroductionMetastatic pancreatic ductal adenocarcinoma (mPDAC) is a common cancer with poor survival outcomes. Although treatment options are...
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Rituximab Monotherapy Is Effective as First-Line Treatment for Granulomatous Lymphocytic Interstitial Lung Disease (GLILD) in CVID Patients
Granulomatous lymphocytic interstitial lung disease (GLILD) represents a fatal immune dysregulatory complication in common variable immunodeficiency...
