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Neonatal magnesium levels are safe after maternal MgSO4 administration: a comparison between unexposed preterm neonates and neonates exposed for fetal neuroprotection or maternal eclampsia prevention—a cohort study
To objective of this study was to compare neonatal magnesemia in the first 15 days of neonatal life between three groups: a control group not exposed...
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Fetal Trauma
The fetus can sustain mechanical trauma during pregnancy or difficult delivery. Approximately 2% of all live births in the USA were exposed to...
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Relaxation of mitochondrial hyperfusion in the diabetic retina via N6-furfuryladenosine confers neuroprotection regardless of glycaemic status
The recovery of mitochondrial quality control (MQC) may bring innovative solutions for neuroprotection, while imposing a significant challenge given...
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The atypical antidepressant tianeptine confers neuroprotection against oxygen–glucose deprivation
Proregenerative and neuroprotective effects of antidepressants are an important topic of inquiry in neuropsychiatric research. Oxygen–glucose...
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Effects of fetal growth restriction on the perinatal neurovascular unit and possible treatment targets
AbstractThe neurovascular unit (NVU) within the brain is a multicellular unit that synergistically acts to maintain blood–brain barrier function and...
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Adenosine receptor A1 enhanced mitochondrial biogenesis and exerted neuroprotection after cerebral ischemia through PGC-1α
Ischemic stroke is a common cause of morbidity and mortality worldwide. The current treatment fails to achieve satisfactory results, because...
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Morphine Induced Neuroprotection in Ischemic Stroke by Activating Autophagy Via mTOR-Independent Activation of the JNK1/2 Pathway
Morphine (Mor) has exhibited efficacy in safeguarding neurons against ischemic injuries by simulating ischemic/hypoxic preconditioning (I/HPC)....
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Human Wharton’s Jelly Mesenchymal Stem Cell Secretome Modifies the Processes of Neuroprotection and Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium at Transcriptional Level
BackgroundRetinal pigment epithelium (RPE) cells are potential targets for treating retinal detachment (RD) and proliferative vitreoretinopathy...
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A systematic review of immune-based interventions for perinatal neuroprotection: closing the gap between animal studies and human trials
BackgroundPerinatal infection/inflammation is associated with a high risk for neurological injury and neurodevelopmental impairment after birth....
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Pharmacological Modulation of Endogenous Neuroprotection after Experimental Prenatal Hypoxia
Abstract —Prenatal hypoxia (PH) causes pathological changes in the brain and can lead to irreversible long-term disorders of brain development and the...
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Neuroprotection and axon regeneration by novel low-molecular-weight compounds through the modification of DOCK3 conformation
Dedicator of cytokinesis 3 (DOCK3) is an atypical member of the guanine nucleotide exchange factors (GEFs) and plays important roles in neurite...
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VCAM-1+ hUC-MSCs Exert Considerable Neuroprotection Against Cerebral Infarction in Rats by Suppression of NLRP3-Induced Pyroptosis
Mesenchymal stem/stromal cells (MSCs) are spindle-like heterogeneous cell populations with advantageous bidirectional immunomodulatory and...
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Noninvasive Techniques to Assess the Development of the Fetal Brain and Nervous System
Fetal brain and neural development is a highly ordered and complex process. Investigating the anatomical and functional characteristics at different...
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cPKCγ-Modulated Autophagy Contributes to Ischemic Preconditioning–Induced Neuroprotection in Mice with Ischemic Stroke via mTOR-ULK1 Pathway
Neuron-specific conventional protein kinase C (cPKC)γ mediates cerebral hypoxic preconditioning (HPC). In parallel, autophagy plays a prosurvival...
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Irisin exhibits neuroprotection by preventing mitochondrial damage in Parkinson’s disease
Exercise has been proposed as an effective non-pharmacological management for Parkinson’s disease (PD) patients. Irisin, a recently identified...
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Neuroprotective effects of maternal melatonin administration in early-onset placental insufficiency and fetal growth restriction
BackgroundEarly-onset fetal growth restriction (FGR) is associated with adverse outcomes. We hypothesised that maternal melatonin administration will...
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Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α7nAchR-dependent inactivation of microglial NLRP3 inflammasome
Ischemic stroke is a major cause of disability and death worldwide, and its management requires urgent attention. Previous studies have shown that...
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Neuroprotection of isookanin against MPTP-induced cell death of SH-SY5Y cells via BCL2/BAX and PI3K/AKT pathways
Background and purposeIsookanin, an important antioxidant component in Coreopsis tinctoria Nutt., has shown remarkable hypolipidemic, hypoglycemic,...
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Pharmacological neuroprotection and clinical trials of novel therapies for neonatal peri-intraventricular hemorrhage: a comprehensive review
Peri-intraventricular hemorrhage (PIVH) is a serious condition for preterm infants, caused by traumatic or spontaneous rupture of the germinal matrix...
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Cellular prion protein offers neuroprotection in astrocytes submitted to amyloid β oligomer toxicity
The cellular prion protein (PrP C ), in its native conformation, performs numerous cellular and cognitive functions in brain tissue. However, despite...
