Search
Search Results
-
Expression Profiles of Estrogen-Regulated MicroRNAs in Cancer Cells
MicroRNAs play critical roles through their impact on posttranscriptional gene regulation. In cancer, they can act as oncogenes or tumor suppressors...
-
Estrogen counteracts age-related decline in beige adipogenesis through the NAMPT-regulated ER stress response
Thermogenic beige adipocytes are recognized as potential therapeutic targets for combating metabolic diseases. However, the metabolic advantages that...
-
An estrogen-regulated long non-coding RNA NCALD promotes luminal breast cancer proliferation by activating GRHL2
PurposeLuminal breast cancer (BC) is a prevalent subtype associated with an increased risk of late disease recurrence and mortality. Long noncoding...
-
Integrating genomics and transcriptomics to identify candidate genes for high egg production in Wulong geese (Anser cygnoides orientalis)
BackgroundWulong geese ( Anser cygnoides orientalis ) are known for their excellent egg-laying performance. However, they show considerable population...
-
Estrogen-regulated AGR3 activates the estrogen receptor signaling pathway to promote tamoxifen resistance in breast cancer
PurposeAnterior gradient 3 (AGR3) is associated with breast cancer progression, but its relationship with estrogen and tamoxifen resistance in breast...
-
USP35, regulated by estrogen and AKT, promotes breast tumorigenesis by stabilizing and enhancing transcriptional activity of estrogen receptor α
Although endocrine therapies targeting estrogen receptor α (ERα) are effective in managing ER positive (+) breast cancer, many patients have primary...
-
Analysis of serum reproductive hormones and ovarian genes in pubertal female goats
BackgroundAge at puberty is an important factor affecting goat fertility, with endocrine and genetic factors playing a crucial role in the onset of...
-
The role of mesenchymal estrogen receptor 1 in mouse uterus in response to estrogen
Estrogens play important roles in uterine growth and homeostasis through estrogen receptors (ESR1 and ESR2). To address the role of ESR1-mediated...
-
2′,3′,4′-Trihydroxychalcone changes estrogen receptor α regulation of genes and breast cancer cell proliferation by a reprogramming mechanism
BackgroundMenopausal hormone therapy (MHT) is recommended for only five years to treat vasomotor symptoms and vulvovaginal atrophy because of safety...
-
Genetic variations in tumor-suppressor miRNA-encoding genes and their target genes: focus on breast cancer development and possible therapeutic strategies
MicroRNAs (miRNAs) negatively affect gene expression by binding to their specific mRNAs resulting in either mRNA destruction or translational...
-
Characterization of PANoptosis-related genes and the immune landscape in moyamoya disease
Moyamoya disease (MMD) is a cerebrovascular narrowing and occlusive condition characterized by progressive stenosis of the terminal portion of the...
-
Distinct epigenetic modulation of differentially expressed genes in the adult mouse brain following prenatal exposure to low-dose bisphenol A
Bisphenol A (BPA) is a common component in the manufacture of daily plastic consumer goods. Recent studies have suggested that prenatal exposure to...
-
Identification of hub genes to determine drug-disease correlation in breast carcinomas
The exact molecular mechanism underlying the heterogeneous drug response against breast carcinoma remains to be fully understood. It is urgently...
-
Cell type-specific potential pathogenic genes and functional pathways in Alzheimer’s Disease
BackgroundAlzheimer's disease (AD) is a pervasive age-related and highly heritable neurodegenerative disorder but has no effective therapy. The...
-
Estrogen-regulated PTTG1 promotes breast cancer progression by regulating cyclin kinase expression
BackgroundThe present study aims to investigate the effects of pituitary tumor transforming gene (PTTG) 1 on breast cancer and its underlying...
-
Endoplasmic reticulum stress-related genes as prognostic and immunogenic biomarkers in prostate cancer
BackgroundThe metastasis and aggressive nature of prostate cancer (PCa) has become a major malignancy related threat that concerns men’s health. The...
-
Prioritization of potential causative genes for schizophrenia in placenta
Our earlier work has shown that genomic risk for schizophrenia converges with early life complications in affecting risk for the disorder and...
-
Transcriptome analysis of the Bactrian camel (Camelus bactrianus) reveals candidate genes affecting milk production traits
BackgroundMilk production traits are complex traits with vital economic importance in the camel industry. However, the genetic mechanisms regulating...
-
Screening and Analysis of Twin Genes in Ovarian Tissue of Yanshan Cashmere Goat
AbstractYanshan cashmere goats are an excellent local breed in China. They produce one kid per litter, however, a few female goats produce twins. To...
-
Identification of hub genes and molecular pathways in keratoconus by integrating bioinformatics and literature mining at the RNA level
ObjectiveKeratoconus (KC) is a condition characterized by progressive corneal steepening and thinning. However, its pathophysiological mechanism...
