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Phytocompounds as potential inhibitors of mycobacterial multidrug efflux pump Rv1258c: an in silico approach
The number of infections and deaths caused by multidrug resistant (MDR) tuberculosis is increasing globally. One of the efflux pumps, that makes Mycoba...
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Structures and Efflux Mechanisms of the AcrAB-TolC Pump
The global emergence of multidrug resistance (MDR) in gram-negative bacteria has become a matter of worldwide concern. MDR in these pathogens is...
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Natural Product as Efflux Pump Inhibitors Against MRSA Efflux Pumps: An Update
Among different nosocomial infections, Staphylococcus aureus, a Gram-positive bacterium, is a highly adaptive human pathogen. Over the years it had...
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Identification of efflux pump inhibitors for Pseudomonas aeruginosa MexAB-OprM via ligand-based pharmacophores, 2D-QSAR, molecular docking, and molecular dynamics approaches
Efflux pumps have been reported as one of the significant mechanisms by which bacteria evade the effects of multiple antibiotics. The tripartite...
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Bacterial Drug Efflux Pump Inhibitors from Plants
The current global antimicrobial resistance (AMR) crisis is a serious hazard to public health, food security, and development. Drug-resistant...
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Deciphering the Role of β-Lactamase Inhibitors, Membrane Permeabilizers and Efflux Pump Inhibitors as Emerging Targets in Antibiotic Resistance
Antimicrobial drugs have been noticed to have reduce activity effective due to upsurge witnessed in resistance of microbes. To deal with viewpoint of...
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Multidrug efflux in Gram-negative bacteria: structural modifications in active compounds leading to efflux pump avoidance
Gram-negative bacteria cause the majority of critically drug-resistant infections, necessitating the rapid development of new drugs with...
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Prenylated isoflavonoids from Fabaceae against the NorA efflux pump in Staphylococcus aureus
Overexpression of NorA efflux pumps plays a pivotal role in the multidrug-resistance mechanism in S. aureus . Here, we investigated the activities of...
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Different Efflux Pump Systems in Acinetobacter baumannii and Their Role in Multidrug Resistance
Several infections, such as pneumonia, urinary tract infections (UTIs), as well as bloodstream, skin, and soft tissue infections, are caused by...
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Inhibition of the norA gene expression and the NorA efflux pump by the tannic acid
The NorA efflux pump of Staphylococcus aureus is known to play a major role in the development of resistance against quinolone drugs by reducing...
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Regulation of overexpressed efflux pump encoding genes by cinnamon oil and trimethoprim to abolish carbapenem-resistant Acinetobacter baumannii clinical strains
Resistance mechanisms are a shelter for Acinetobacter baumannii to adapt to our environment which causes difficulty for the infections to be treated...
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Efflux Pump Inhibition-Based Screening and Anti-Infective Evaluation of Punica granatum Against Bacterial Pathogens
Drug efflux pumps contribute to bacterial multidrug resistance (MDR), reducing antibiotic effectiveness and causing treatment failures. Besides their...
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Characterization of genes related to the efflux pump and porin in multidrug-resistant Escherichia coli strains isolated from patients with COVID-19 after secondary infection
BackgroundEscherichia coli ( E. coli ) is a multidrug resistant opportunistic pathogen that can cause secondary bacterial infections in patients with...
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Escherichia coli resistance mechanism AcrAB-TolC efflux pump interactions with commonly used antibiotics: a molecular dynamics study
While antibiotic resistance poses a threat from both Gram-positive bacteria (GPB) and Gram-negative bacteria (GNB), GNB pose a more imminent public...
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The anti-staphylococcal fusidic acid as an efflux pump inhibitor combined with fluconazole against vaginal candidiasis in mouse model
BackgroundCandida albicans is the most common fungus that causes vaginal candidiasis in immunocompetent women and catastrophic infections in...
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Insight into the on/off switch that regulates expression of the MSMEG-3762/63 efflux pump in Mycobacterium smegmatis
Drug resistance is one of the most difficult challenges facing tuberculosis (TB) control. Drug efflux is among the mechanisms leading to drug...
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Antimycobacterial, antibiofilm and efflux pump inhibitory activity of extracts from selected Combretum species used in traditional medicine in Zimbabwe
Non-tuberculous mycobacteria infect mostly immunocompromised people. NTM infections incidence and prevalence increase has led to a public health...
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Efflux pump inhibitor, phenylalanine-arginine beta-naphthylamide analog potentiates the activity of 5-O-mycaminosyltylonolide for multi-drug resistant Pseudomonas aeruginosa
The emergence and spread of antimicrobial resistance are global threats. Pseudomonas aeruginosa ( P. aeruginosa ) is responsible for a substantial...
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Rejuvenating the Potential of Antimicrobials Via Targeted Therapy of Efflux Pumps: The Advent of Phytotherapeutics
Antimicrobial resistance (AMR) and the emergence of multidrug-resistant organisms are one of the most eminent impediments of recent times. The...
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AcrAB-TolC efflux pump overexpression and tet(A) gene mutation increase tigecycline resistance in Klebsiella pneumoniae
Tigecycline-non-susceptible Klebsiella pneumoniae (TNSKP) is increasing and has emerged as a global public health issue. However, the mechanism of...
