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Anticalcification effects of DS-1211 in pseudoxanthoma elasticum mouse models and the role of tissue-nonspecific alkaline phosphatase in ABCC6-deficient ectopic calcification
Pseudoxanthoma elasticum (PXE) is a multisystem, genetic, ectopic mineralization disorder with no effective treatment. Inhibition of...
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A new perspective on intervertebral disc calcification—from bench to bedside
Disc degeneration primarily contributes to chronic low back and neck pain. Consequently, there is an urgent need to understand the spectrum of disc...
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Vascular Calcification and Calciphylaxis in Peritoneal Dialysis Patients
Cardiovascular disease is the leading cause of death in end-stage renal disease (ESRD) patients, including hemodialysis and peritoneal dialysis (PD)....
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Ectopic Mineralization Following Liver Transplantation—Mechanisms, Risks, and Management: A Review
A progressive calcification/mineralization that occurs ectopically (other than teeth, cartilage, and bone) following orthotopic liver...
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Early diagnosis of aortic calcification through dental X-ray examination for dental pulp stones
Vascular calcification, an ectopic calcification exacerbated by aging and renal dysfunction, is closely associated with cardiovascular disease....
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An Unusual Case of Transient Cardiac Calcification Identified on Antenatal Echocardiography: A Generalized Arterial Calcification of Infancy (GACI) Like Presentation
Generalised arterial calcification of infancy (GACI) is an ultra-rare life-threatening genetic disorder. Arterial calcification is identified during...
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Calcification of Bones and Teeth
Calcification (mineralization) refers to a series of processes by which insoluble calcium salts are deposited on the extracellular matrix, which is...
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Ectopic Pregnancy: Diagnosis and Complications
The fallopian tube extends from the ovary to the corners of the uterus and plays a crucial role in reproduction. Many reactive and benign conditions...
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Cutaneous Calcification
Normally, calcium and phosphate are in a relatively stable equilibrium in extracellular fluids. In ectopic calcifications, precipitation and...
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Optic disc drusen: Dystrophic calcification, a potential target for treatment
Optic disc drusen (ODD) are calcified, acellular bodies, seen in the optic nerve head of up to 2% of the population. Although seldomly affecting...
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Ectopic Cervical Thymus in Adult: An Incidental Finding
Thymus is a paired organ which develops during the sixth week of fetal life, attains maximum size by three years and involutes in adult life....
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Fibroblasts’ secretome from calcified and non-calcified dermis in Pseudoxanthoma elasticum differently contributes to elastin calcification
Pseudoxanthoma elasticum (PXE) is a rare disease characterized by ectopic calcification, however, despite the widely spread effect of...
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Role of the extracellular ATP/pyrophosphate metabolism cycle in vascular calcification
Conventionally, ATP is considered to be the principal energy source in cells. However, over the last few years, a novel role for ATP as a potent...
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SNF472: a novel therapeutic agent for vascular calcification and calciphylaxis
Vascular calcification is a common complication in patients with chronic kidney disease (CKD) and is strongly associated with an increased risk of...
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Stiffness and axial pain are associated with the progression of calcification in a mouse model of diffuse idiopathic skeletal hyperostosis
BackgroundDiffuse idiopathic skeletal hyperostosis (DISH) is characterized by progressive calcification of spinal tissues; however, the impact of...
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Magnesium inhibits peritoneal calcification as a late-stage characteristic of encapsulating peritoneal sclerosis
Peritoneal calcification is a prominent feature of the later stage of encapsulating peritoneal sclerosis (EPS) in patients undergoing long-term...
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Bisphosphonate FYB-931 Prevents High Phosphate-Induced Vascular Calcification in Rat Aortic Rings by Altering the Dynamics of the Transformation of Calciprotein Particles
Patients with chronic kidney disease develop vascular calcification, owing to impaired calcium and phosphate metabolism. The prevention of vascular...
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Correlation of systemic involvement and presence of pathological skin calcification assessed by ex vivo nonlinear microscopy in Pseudoxanthoma elasticum
Pseudoxanthoma elasticum (PXE (OMIM 264800)) is an autosomal recessive connective tissue disorder mainly caused by mutations in the ABCC6 gene. PXE...
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Cartilage calcification in osteoarthritis: mechanisms and clinical relevance
Pathological calcification of cartilage is a hallmark of osteoarthritis (OA). Calcification can be observed both at the cartilage surface and in its...
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Ectopic Lingual Thyroid—A Rare Presentation
Lingual thyroid is a rare clinical entity due to failure of the embryonic gland to descend to its normal pretracheal location. We report a case of 29...
