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Recommendations for Examining Police Deescalation and use of Force Training, Policies, and Outcomes
Demands for police reforms to address racial injustice and excessive force have increased since the release of a video showing George Floyd dying as...
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Inflammatory Breast Cancer: Is There a Role for Deescalation of Surgery?
Inflammatory breast cancer (IBC) is a rare and aggressive presentation of breast cancer, characterized by higher propensity for locoregional...
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A new function for drug combination dose finding trials
Combination drugs play an essential role in treating cancers. The challenging part of the combination drugs are to specify the dose-toxicity...
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Anthracyclines versus No Anthracyclines in the Neoadjuvant Strategy for HER2+ Breast Cancer: Real-World Evidence
Background and ObjectivesDeescalation strategies omitting anthracyclines (AC) have been explored in early human epidermal growth factor receptor...
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Contemporary Axillary Surgical Management in Patients with Pathologically Node Positive Disease After Neoadjuvant Chemotherapy: A Survey of Members of the American Society of Breast Surgeons
BackgroundAxillary lymph node dissection (ALND) is increasingly omitted for breast cancer patients with pathologic nodal disease after neoadjuvant...
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Contemporary Axillary Management in cT1–2N0 Breast Cancer with One or Two Positive Sentinel Lymph Nodes: Factors Associated with Completion Axillary Lymph Node Dissection Within the National Cancer Database
BackgroundManagement of the axilla in patients with cT1–2N0 breast cancer with one or two positive (+) sentinel lymph nodes (SLNs) is often debated,...
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Project ENHANCE: Assessing Professional Learning Needs for Implementing Comprehensive, Integrated, Three-Tiered (Ci3T) Models of Prevention
We report findings from a multistate survey of 720 faculty and staff from 25 elementary schools in five districts across three states and geographic...
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Neoadjuvant Imatinib in Locally Advanced Gastrointestinal Stromal Tumors (GISTs) is Effective and Safe: Results from a Prospective Single-Center Study with 108 Patients
BackgroundNeoadjuvant imatinib is considered for gastrointestinal stromal tumors (GISTs) when decreased tumor size provides less extensive surgery...
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Phase I Designs for Late-Onset Toxicity
Late-onset toxicity is common for immunotherapies and targeted therapies. It causes major logistic difficulty in conducting phase I trials using most...
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Surgical Management of Axilla Following Neoadjuvant Endocrine Therapy
BackgroundRandomized clinical trials support deescalation of axillary surgery in breast cancer patients with low-volume axillary disease treated with...
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Is mental health staff training in de-escalation techniques effective in reducing violent incidents in forensic psychiatric settings? – A systematic review of the literature
BackgroundInpatient violence is a relevant issue in forensic psychiatric settings. Relevant guidelines recommend that restrictive measures are to be...
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(Neo)adjuvant approaches: pavement on the road to cure—breast cancer
During the past few decades, major advances have been achieved in the treatment of early breast cancer (BC) resulting in improvements of inavasive...
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Causes, Predictors, and Timing of Early Neurological Deterioration and Symptomatic Intracranial Hemorrhage After Administration of IV tPA
BackgroundAcute ischemic stroke (AIS) is a major contributor toward healthcare-associated costs and services. Symptomatic intracranial hemorrhage...
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Maxillofacial Trauma
This case will review the management of an agitated patient who was assaulted with maxillofacial trauma. Providers must review deescalation...
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The Prognostic Value of Axillary Staging Following Neoadjuvant Chemotherapy in Inflammatory Breast Cancer
BackgroundInflammatory breast cancer (IBC) has historically been characterized by high rates of recurrence and poor survival; however, there have...
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Survival After Contralateral Secondary Breast Cancer by Age Group in California
PurposeBreast cancer (BC) is the most common secondary cancer and has poorer survival than primary BC (pBC) after any prior malignancy. For BC...
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De-escalation of Post-mastectomy Irradiation in Hormone Receptor-Positive Breast Cancer with One to Three Positive Nodes
BackgroundThe 21-gene recurrence score (RS) is used to predict benefit from chemotherapy in hormone receptor (HR)-positive breast cancer with one to...
