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Gastroparesis Worsens Indomethacin-Induced Gastric Antral Ulcers by Bile Reflux via Activation of 5-HT3 and Dopamine D2 Receptors in Mice
Background/AimsWe examined the contributions of gastric emptying and duodenogastric bile reflux in the formation of gastric antral ulcers induced by...
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Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis
Direct interactions between receptors at the neuronal surface have long been proposed to tune signaling cascades and neuronal communication in health...
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Initial characterization of a transgenic mouse with overexpression of the human D1-dopamine receptor in the heart
Dopamine can exert effects in the mammalian heart via five different dopamine receptors. There is controversy whether dopamine receptors increase...
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Dopamine D2 receptors in nucleus accumbens cholinergic interneurons increase impulsive choice
Impulsive choice, often characterized by excessive preference for small, short-term rewards over larger, long-term rewards, is a prominent feature of...
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Dopamine receptors of the rodent fastigial nucleus support skilled reaching for goal-directed action
The dopaminergic (DA) system regulates both motor function, and learning and memory. The cerebellum supports motor control and the acquisition of...
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Optimized design and in vivo application of optogenetically functionalized Drosophila dopamine receptors
Neuromodulatory signaling via G protein-coupled receptors (GPCRs) plays a pivotal role in regulating neural network function and animal behavior. The...
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Isoliquiritigenin, a potent human monoamine oxidase inhibitor, modulates dopamine D1, D3, and vasopressin V1A receptors
Isoliquiritigenin (= 4,2′,4′-Trihydroxychalcone) (ILG) is a major constituent of the Glycyrrhizae Rhizoma that has significant neuroprotective...
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Analysis of Dopamine D1- and D2-Receptors Effect on Renal Osmoregulatory Function in Rats with Different Blood Vasopressin Level
AbstractWe studied the effect of D 1 - and D 2 -like dopamine receptors on the modulation of the renal osmoregulatory function in WAG and...
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Blocking D2/D3 dopamine receptors in male participants increases volatility of beliefs when learning to trust others
The ability to learn about other people is crucial for human social functioning. Dopamine has been proposed to regulate the precision of beliefs, but...
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Dopamine-induced astrocytic Ca2+ signaling in mPFC is mediated by MAO-B in young mice, but by dopamine receptors in adult mice
Dopamine (DA) plays a vital role in brain physiology and pathology such as learning and memory, motor control, neurological diseases, and psychiatric...
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Optogenetic activation of dopamine D1 receptors in island cells of medial entorhinal cortex inhibits temporal association learning
A critical feature of episodic memory formation is to associate temporally segregated events as an episode, called temporal association learning. The...
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Prefrontal and striatal dopamine D2/D3 receptors correlate with fMRI BOLD activation during stop**
D 2 -like dopamine receptors in animals and humans have been shown to be linked to impulsive behaviors that are highly relevant for several psychiatric...
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The effects of the recurrent social isolation stress on fear extinction and dopamine D2 receptors in the amygdala and the hippocampus
BackgroundThe present study assessed the influence of recurrent social isolation stress on the aversive memory extinction and dopamine D 2 receptors...
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Social interaction-induced fear memory reduction: exploring the influence of dopamine and oxytocin receptors on memory updating
It has been well established that a consolidated memory can be updated during the plastic state induced by reactivation. This updating process opens...
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Blockade of the Dopamine D3 Receptor Attenuates Opioids-Induced Addictive Behaviours Associated with Inhibiting the Mesolimbic Dopamine System
Opioid use disorder (OUD) has become a considerable global public health challenge; however, potential medications for the management of OUD that are...
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Nucleus accumbens core dopamine D2 receptors are required for performance of the odor span task in male rats
RationaleThe nucleus accumbens (NAc) core gates motivationally relevant behavioral action sequences through afferents from cortical and subcortical...
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Intermittent Restraint Stress and Recovery on GPCR Expression in Brain/Gut Axis of Mice: Activation of Adrenergic, Dopamine, Serotonin and Melatonin Receptors During Stress and Ease Response
G protein-coupled receptors (GPCRs) comprise the largest family of integral membrane proteins that regulate many important physiological functions....
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The Effects of Chronic Marijuana Administration on 6-OHDA-Induced Learning & Memory Impairment and Hippocampal Dopamine and Cannabinoid Receptors Interaction in Male Rats
There are general inhibitory effects of exo-cannabinoids on dopamine-mediated behaviors. Many studies suggested the interaction between cannabinoid...
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Differential Roles of the D1- and D2-Like Dopamine Receptors Within the Ventral Tegmental Area in Modulating the Antinociception Induced by Forced Swim Stress in the Rat
Several preclinical and clinical studies indicate that exposure to acute stress may decrease pain perception and increases pain tolerance. This...
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Behavioral characteristics of dopamine D5 receptor knockout mice
Major psychiatric disorders such as attention-deficit/hyperactivity disorder and schizophrenia are often accompanied by elevated impulsivity....
