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The assembly of the Mitochondrial Complex I Assembly complex uncovers a redox pathway coordination
The Mitochondrial Complex I Assembly (MCIA) complex is essential for the biogenesis of respiratory Complex I (CI), the first enzyme in the...
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Mitochondrial complex I activity in microglia sustains neuroinflammation
Sustained smouldering, or low-grade activation, of myeloid cells is a common hallmark of several chronic neurological diseases, including multiple...
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Residual Complex I activity and amphidirectional Complex II operation support glutamate catabolism through mtSLP in anoxia
Anoxia halts oxidative phosphorylation (OXPHOS) causing an accumulation of reduced compounds in the mitochondrial matrix which impedes...
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Hybrid Mn(II)–Cu(I) Complex Based on 1,3,5-Tris(diphenylphosphinyl)benzene
AbstractThe reaction of 1,3,5-tris(diphenylphosphinylbenzene (L) with MnI 2 in the presence of CuI (wet MeCN, 25°C, 30 min) leads to the formation of...
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Identification of a family of species-selective complex I inhibitors as potential anthelmintics
Soil-transmitted helminths (STHs) are major pathogens infecting over a billion people. There are few classes of anthelmintics and there is an urgent...
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A lethal mitonuclear incompatibility in complex I of natural hybrids
The evolution of reproductive barriers is the first step in the formation of new species and can help us understand the diversification of life on...
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Mitochondrial complex I deficiency stratifies idiopathic Parkinson’s disease
Idiopathic Parkinson’s disease (iPD) is believed to have a heterogeneous pathophysiology, but molecular disease subtypes have not been identified....
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Amino acid insertion in Bat MHC-I enhances complex stability and augments peptide presentation
Bats serve as reservoirs for numerous zoonotic viruses, yet they typically remain asymptomatic owing to their unique immune system. Of particular...
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Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials
Although targeting oxidative phosphorylation (OXPHOS) is a rational anticancer strategy, clinical benefit with OXPHOS inhibitors has yet to be...
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Complex Endosymbioses I: From Primary to Complex Plastids, Serial Endosymbiotic Events
A considerable part of the diversity of eukaryotic phototrophs consists of algae with plastids that evolved from endosymbioses between two...
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Neuronal MHC-I complex is destabilized by amyloid-β and its implications in Alzheimer’s disease
BackgroundsThe expression of major histocompatibility complex I (MHC-I) in neurons has recently been shown to regulate neurite outgrowth and synaptic...
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Structure of the transcription open complex of distinct σI factors
Bacterial σ I factors of the σ 70 -family are widespread in Bacilli and Clostridia and are involved in the heat shock response, iron metabolism,...
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Mitochondrial variants of complex I genes associated with leprosy clinical subtypes
Leprosy is a chronic bacterial infection mainly caused by Mycobacterium leprae that primarily affects skin and peripheral nerves. Due to its ability...
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Nuclear Genome-Encoded Mitochondrial OXPHOS Complex I Genes in Female Buffalo Show Tissue-Specific Differences
Buffalo physiology intricately balances energy, profoundly influencing health, productivity, and reproduction. This study explores...
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A universal coupling mechanism of respiratory complex I
Complex I is the first enzyme in the respiratory chain, which is responsible for energy production in mitochondria and bacteria
1 . Complex I couples...
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Mechanism of rotenone binding to respiratory complex I depends on ligand flexibility
Respiratory complex I is a major cellular energy transducer located in the inner mitochondrial membrane. Its inhibition by rotenone, a natural...
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Systematic analysis of NDUFAF6 in complex I assembly and mitochondrial disease
Isolated complex I (CI) deficiencies are a major cause of primary mitochondrial disease. A substantial proportion of CI deficiencies are believed to...
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iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I
Proteolytic release of transmembrane proteins from the cell surface, the so called ectodomain shedding, is a key process in inflammation. Inactive...
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An anthraquinone-based Cu(I) cyclic trinuclear complex for photo-catalyzing C-C coupling reactions
Development of transition metal-based photocatalysts with low cost, strong visible light absorption, and high efficiency is a long-stand pursuit for...
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Structure of an MHC I–tapasin–ERp57 editing complex defines chaperone promiscuity
Adaptive immunity depends on cell surface presentation of antigenic peptides by major histocompatibility complex class I (MHC I) molecules and on...
