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Pumilio-1 mediated translational control of claudin-5 at the blood-brain barrier
AbstractClaudin-5 is one of the most essential tight junction proteins at the blood-brain barrier. A single nucleotide polymorphism rs10314 is...
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Teriflunomide Promotes Blood–Brain Barrier Integrity by Upregulating Claudin-1 via the Wnt/β-catenin Signaling Pathway in Multiple Sclerosis
The blood–brain barrier (BBB) and tight junction (TJ) proteins maintain the homeostasis of the central nervous system (CNS). The dysfunction of BBB...
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Identification of a Novel Homozygous Missense Mutation in the CLDN16 Gene to Decipher the Ambiguous Clinical Presentation Associated with Autosomal Dominant Hypocalcaemia and Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis in an Indian Family
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHNNC) is a rare autosomal recessive renal tubulopathy disorder characterized by...
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Development of tight junction-strengthening compounds using a high-throughput screening system to evaluate cell surface-localized claudin-1 in keratinocytes
Tight junctions (TJs) are important factors constituting the physical barriers of the skin, and their suppression has been described in various...
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Lactobacillus-derived metabolites enhance the antitumor activity of 5-FU and inhibit metastatic behavior in 5-FU-resistant colorectal cancer cells by regulating claudin-1 expression
Lactobacillus plantarum -derived metabolites (LDMs) increase drug sensitivity to 5-FU and antimetastatic effects in 5-FU-resistant colorectal cancer...
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Claudin-Targeted Suicide Gene Therapy for Claudin-Overexpressing Tumor Cells by Using Modified Clostridium perfringens Enterotoxin (CPE)
Bacterial toxins gain growing attention as potential cancer treatment due to their potent cytotoxic effects. Among the very different toxins with...
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Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome
BackgroundDelay in type II alveolar epithelial cell (AECII) regeneration has been linked to higher mortality in patients with acute respiratory...
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The effect of prolonged interval and continuous exercise in the heat on circulatory markers of intestinal barrier integrity
PurposeThe purpose of this study was to determine the effect of prolonged high-intensity interval (INT) and moderate-intensity continuous (CONT)...
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The Impact of Paracoccidioides spp Infection on Central Nervous System Cell Junctional Complexes
Paracoccidioidomycosis (PCM), a systemic mycosis caused by the fungus Paracoccidioides spp . is the most prevalent fungal infection among...
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A single mutation in the E2 glycoprotein of hepatitis C virus broadens the claudin specificity for its infection
Entry of the hepatitis C virus (HCV) into host cells is a multistep process mediated by several host factors, including a tight junction protein...
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Effects of histone deacetylase inhibitors Tricostatin A and Quisinostat on tight junction proteins of human lung adenocarcinoma A549 cells and normal lung epithelial cells
Histone deacetylase (HDAC) inhibitors have a potential therapeutic role for non-small cell lung cancer (NSCLC). However, more preclinical studies of...
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Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently
The transmembrane protein claudin-1 is a major component of epidermal tight junctions (TJs), which create a dynamic paracellular barrier in the...
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Human peritoneal tight junction, transporter and channel expression in health and kidney failure, and associated solute transport
Next to the skin, the peritoneum is the largest human organ, essentially involved in abdominal health and disease states, but information on...
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Cellular Distribution Pattern of tjp1 (ZO-1) in Xenopus laevis Oocytes Heterologously Expressing Claudins
Epithelial barriers constitute a fundamental requirement in every organism, as they allow the separation of different environments and set boundaries...
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Molecular markers predicting the progression and prognosis of human papillomavirus-induced cervical lesions to cervical cancer
IntroductionPersistent Human Papillomavirus (HPV) infection is linked to 99% of cervical cancer (CC) cases. HPV types 16 and 18 alone result in 75%...
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18β-Glycyrrhetinic acid altered the intestinal permeability in the human Caco-2 monolayer cell model
PurposeGlycyrrhizin (GL) and its metabolites 18α-glycyrrhetinic acid (18α-GA) and 18β-glycyrrhetinic acid (18β-GA) are used as traditional medicine...
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The Influence of Various Freezing–thawing Methods of Skin on Drug Permeation and Skin Barrier Function
The selection of skin is crucial for the in vitro permeation test (IVPT). The purpose of this study was to investigate the influence of different...
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Dietary supplemental coated essential oils and organic acids mixture improves growth performance and gut health along with reduces Salmonella load of broiler chickens infected with Salmonella Enteritidis
BackgroundReducing Salmonella infection in broiler chickens by using effective and safe alternatives to antibiotics is vital to provide safer...
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Differential effects of intense exercise and pollution on the airways in a murine model
BackgroundExercise-induced bronchoconstriction (EIB) is a transient airway narrowing, occurring during or shortly after intensive exercise. It is...
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Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line
BackgroundBlood-brain barrier (BBB) models based on primary murine, bovine, and porcine brain capillary endothelial cell cultures have long been...
