Search
Search Results
-
Atypical chemokine receptors in the immune system
Leukocyte migration is a fundamental component of innate and adaptive immune responses as it governs the recruitment and localization of these motile...
-
Chemokines and Chemokine Receptors in Cancer: An Update
The chemokine family is composed of small chemotactic cytokines and receptors that mediate the infiltration of various immune cells. According to the...
-
CC chemokine receptors are prognostic indicators of gastric cancer and are associated with immune infiltration
BackgroundCC chemokine receptors are responsible for regulating the tumor microenvironment (TME) and participating in carcinogenesis and tumor...
-
Structural basis of dimerization of chemokine receptors CCR5 and CXCR4
G protein-coupled receptors (GPCRs) are prominent drug targets responsible for extracellular-to-intracellular signal transduction. GPCRs can form...
-
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3
Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present...
-
Population Rearrangement of B Lymphocytes Expressing Chemokine Receptors in Patients with Chronic Obstructive Pulmonary Disease
Abstract —To date, there are no drugs that can prevent progressive destruction of lung tissue and small airway fibrosis in patients with chronic...
-
Chemokine- and chemokine receptor-based signature predicts immunotherapy response in female colorectal adenocarcinoma patients
The clinical significance and comprehensive characteristics of chemokines and chemokine receptors in female patients with advanced colorectal...
-
Cytokine and Chemokine Networks in Cancer
Cytokine and Chemokine Networks in Cancer" provides a comprehensive exploration of the roles of cytokines and chemokines in cancer biology. It offers...
-
Chemokines and chemokine receptors in allergic rhinitis: from mediators to potential therapeutic targets
Allergic rhinitis (AR) is an immune-mediated inflammatory condition characterized by immune cell infiltration of the nasal mucosa, with symptoms of...
-
Chemokine receptors differentially expressed by race category and molecular subtype in the breast cancer TCGA cohort
Racial disparities in mortality due to metastasis remain significant among breast cancer patients. Chemokine receptors contribute to breast tumors...
-
Research progress of the chemokine/chemokine receptor axes in the oncobiology of multiple myeloma (MM)
BackgroundThe incidence of multiple myeloma (MM), a type of blood cancer affecting monoclonal plasma cells, is rising. Although new drugs and...
-
Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8
The C-C motif chemokine receptor 8 (CCR8) is a class A G-protein coupled receptor that has emerged as a promising therapeutic target in cancer....
-
Introduction to Cytokine and Chemokine Networks
Cytokines are small-molecular-weight, proteinaceous, immunomodulating molecules that are crucial for controlling the growth and activity of blood and...
-
Chemokine and Cytokine Networks in Tumor Microenvironment
A large family of tiny chemotactic cytokines direct the migration of immune cells and is known as chemokines. Chemotactic factors help the immune...
-
The chemokine receptor CCR5: multi-faceted hook for HIV-1
Chemokines are cytokines whose primary role is cellular activation and stimulation of leukocyte migration. They perform their various functions by...
-
“Glyco-sulfo barcodes” regulate chemokine receptor function
Chemokine ligands and receptors regulate the directional migration of leukocytes. Post-translational modifications of chemokine receptors including...
-
Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation
To fulfil its orchestration of immune cell trafficking, a network of chemokines and receptors developed that capitalizes on specificity, redundancy,...
-
Areca Thirteen Pill Improves Depression in Rat by Modulation of the Chemokine/Chemokine Receptor Axis
Depressive disorder is a severe and complex mental illness. There are a few anti-depressive medications that can reduce depressive symptoms, but with...
-
New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine
Over the past thirty years, the importance of chemokines and their seven-transmembrane G protein-coupled receptors (GPCRs) has been increasingly...
-
Structural basis of CXC chemokine receptor 1 ligand binding and activation
Neutrophil granulocytes play key roles in innate immunity and sha** adaptive immune responses. They are attracted by chemokines to sites of...
