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Drug Induced Liver Injury
Hepatotoxicity is toxic damage to the liver that includes the nature of the hepatotoxic agent, the type and mechanism of liver injury, the...
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Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update
Drug-induced liver injury (DILI) is an important adverse drug reaction that can lead to acute liver failure or even death in severe cases. Currently,...
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Drug-induced liver injury due to tofacitinib: a case report
BackgroundDrug-induced liver injury is an acute or chronic liver damage in response to drugs, herbals, and any chemical compound.
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The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury
Mitochondria are critical for metabolic homeostasis of the liver, and their dysfunction is a major cause of liver diseases. Optic atrophy 1 (OPA1) is...
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Drug-Induced Liver Injury in the Elderly: Consensus Statements and Recommendations from the IQ-DILI Initiative
The elderly demographic is the fastest-growing segment of the worldās population and is projected to exceed 1.5 billion people by 2050. With...
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Modeling drug-induced liver injury and screening for anti-hepatofibrotic compounds using human PSC-derived organoids
Preclinical models that can accurately predict the toxicity and efficacy of candidate drugs to human liver tissue are in urgent need. Human liver...
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Identification of MRI features associated with injury type, severity, and prognosis in drug-induced liver injury
ObjectivesTo identify magnetic resonance imaging (MRI) features associated with injury type, severity, and liver transplantation (LT)/liver-related...
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Interpretable machine learning in predicting drug-induced liver injury among tuberculosis patients: model development and validation study
BackgroundThe objective of this research was to create and validate an interpretable prediction model for drug-induced liver injury (DILI) during...
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A brief overview of drug-induced liver damage
Drug-induced liver injury (DILI) is a prevalent disorder that can be led on by almost all drug types. The majority of benign DILI cases become better...
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Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: Analysis of suspected cases
PurposeSelective androgen receptor modulators (SARMs) have demonstrated agonist activity on the androgen receptor in various tissues, stimulating...
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InterDILI: interpretable prediction of drug-induced liver injury through permutation feature importance and attention mechanism
Safety is one of the important factors constraining the distribution of clinical drugs on the market. Drug-induced liver injury (DILI) is the leading...
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Unraveling the treatment effects of huanglian jiedu decoction on drug-induced liver injury based on network pharmacology, molecular docking and experimental validation
Huanglian Jiedu Decoction (HJD) is a well-known Traditional Chinese Medicine formula that has been used for liver protection in thousands of years....
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The immunological mechanisms and therapeutic potential in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity
Acute liver failure caused by drug overdose is a significant clinical problem in developed countries. Acetaminophen (APAP), a widely used analgesic...
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Polymorphisms in drug metabolism genes as a risk factor for first-line anti-tuberculosis drug-induced liver injury
BackgroundAnti-tuberculosis drug-induced liver injury (AT-DILI) is one of the most common side effects in TB patients during treatment. The prime...
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Artificial Intelligence-Based Techniques to Assess Drug Toxicity in Drug-Induced Liver Injury (DILI) Disease
Drug-induced liver injury (DILI) is difficult to detect, and a rare condition which is responsible for drug removal from the market. DILI poses a...
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A system that delivers an antioxidant to mitochondria for the treatment of drug-induced liver injury
Mitochondria, a major source of reactive oxygen species (ROS), are intimately involved in the response to oxidative stress in the body. The...
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Transcriptional profiling of drug-induced liver injury biomarkers: association of hepatic Srebf1/PparĪ± signaling and crosstalk of thrombin, alcohol dehydrogenase, MDR and DNA damage regulators
Cell stress transcribing genes provide a diverse platform of molecular mediators that vary in response to toxicity. Common drug-induced liver injury...
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Cholangiocyte organoids to study drug-induced injury
BackgroundDrug induced bile duct injury is a frequently observed clinical problem leading to a wide range of pathological features. During the past...
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Unraveling the mechanisms underlying drug-induced cholestatic liver injury: identifying key genes using machine learning techniques on human in vitro data sets
Drug-induced intrahepatic cholestasis (DIC) is a main type of hepatic toxicity that is challenging to predict in early drug development stages....
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Drug-Induced Nephrotoxicity and Use of Biomarkers
Nephrotoxicity has been defined as renal injury that is caused due to direct or indirect exposure, mostly to drugs and other exogenous industrial or...