Search
Search Results
-
Cellular Stress, Survival Mechanism and Adaptation
At the cellular level, stress can be defined as an array of processes that get sparked as a result of an external stimulus, thereby leading to acute...
-
Replication stress as a driver of cellular senescence and aging
Replication stress refers to slowing or stalling of replication fork progression during DNA synthesis that disrupts faithful copying of the genome....
-
ATF4 in cellular stress, ferroptosis, and cancer
Activating transcription factor 4 (ATF4), a member of the ATF/cAMP response element-binding (CREB) family, plays a critical role as a stress-induced...
-
Cellular Responses Against Abiotic Stress-Induced Reactive Oxygen Species
This chapter explores molecular mechanisms underlying behind molecular pathways triggered by excessive reactive oxygen species (ROS) production due...
-
Oxidative Stress Triggered Damage to Cellular Biomolecules
Over-production of reactive oxygen species (ROS) within plant cell on the perception of abiotic and biotic stress is an inescapable phenomenon. The...
-
Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis
The burden of chronic liver disease is rising substantially worldwide. Fibrosis, characterized by excessive deposition of extracellular matrix...
-
Interplay of oxidative stress, cellular communication and signaling pathways in cancer
Cancer remains a significant global public health concern, with increasing incidence and mortality rates worldwide. Oxidative stress, characterized...
-
Nuclear GAPDH in cortical microglia mediates cellular stress-induced cognitive inflexibility
We report a mechanism that underlies stress-induced cognitive inflexibility at the molecular level. In a mouse model under subacute cellular stress...
-
MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses
FOXO3 is a member of the FOXO transcription factor family and is known for regulating cellular survival in response to stress caused by various...
-
Orchestration of inflammation in contact allergy by innate immune and cellular stress responses
BackgroundInflammation is central to the initiation of immune responses and to the pathogenesis of many diseases such as allergic contact dermatitis...
-
Response of Cellular Stress Toward the Hormetic Phytochemicals in Brain Aging
As people age, their brain cells undergo various types of stress that can lead to neurodegeneration and cognitive decline. One potential strategy for...
-
-
Molecular Mechanisms Underpinning Plant Stress Responses: Insights into the Cellular and Systemic Regulation
Plants are under constant environmental stress including extreme temperature, salinity, drought as well as insect and pathogen problems, which affect...
-
Cellular forgetting, desensitisation, stress and ageing in signalling networks. When do cells refuse to learn more?
Recent findings show that single, non-neuronal cells are also able to learn signalling responses develo** cellular memory. In cellular learning...
-
Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescence
Nuclear decoupling and softening are the main cellular mechanisms to resist mechanical stress-induced nuclear/DNA damage, however, its molecular...
-
Hepa-ToxMOA: a pathway-screening method for evaluating cellular stress and hepatic metabolic-dependent toxicity of natural products
In the field of drug discovery, natural products have emerged as therapeutic agents for diseases such as cancer. However, their potential toxicity...
-
Long noncoding RNAs as versatile molecular regulators of cellular stress response and homeostasis
Normal cell and body functions need to be maintained and protected against endogenous and exogenous stress conditions. Different cellular stress...
-
The environmental cellular stress response: the intertidal as a multistressor model
The wild poses a multifaceted challenge to the maintenance of cellular function. Therefore, a multistressor approach is essential to predict the...
-
Intrinsically dysregulated cellular stress signaling genes and gene networks in postpartum depression
Postpartum depression (PPD) is a leading cause of morbidity and mortality among women. Clinically, the administration and withdrawal of...
-
Remodeling the cellular stress response for enhanced genetic code expansion in mammalian cells
Genetic code expansion (GCE) reprograms the translational machinery to site-specifically incorporate noncanonical amino acids (ncAAs) into a selected...
