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Prolonged efficacy of cefazolin in intraosseous regional prophylaxis for total knee arthroplasty: a rabbit model study
BackgroundA novel approach known as intraosseous regional administration (IORA) has emerged as a technique for delivering prophylactic antibiotics,...
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Flucloxacillin and cefazolin for treatment of Staphylococcus aureus bloodstream infection
PurposeAntistaphylococcal penicillins and cefazolin have been used as first line therapy in Methicillin-susceptible Staphylococcus aureus bloodstream...
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Addition of vancomycin to cefazolin is often unnecessary for preoperative antibiotic prophylaxis during total joint arthroplasties
PurposeThe gold standard to decrease total joint arthroplasty (TJA) periprosthetic joint infection (PJI) is preoperative antibiotic prophylaxis....
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Prospective assessment of the frequency of and risk factors for bleeding events in patients treated with cefazolin
PurposeMajor bleedings have been described with cefazolin. The objective was to determine the frequency of bleeding events in cefazolin-treated...
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Higher cefazolin concentrations in synovial fluid with intraosseous regional prophylaxis in knee arthroplasty: a randomized controlled trial
BackgroundProphylactic antibiotics reduce the risk of periprosthetic joint infection. However, conventional systemic administration may not provide...
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Effectiveness and safety of cefazolin versus cloxacillin in endocarditis due to methicillin-susceptible Staphylococcus spp.: a multicenter propensity weighted cohort study
PurposeTo compare the effectiveness and safety of cefazolin versus cloxacillin for the treatment of infective endocarditis (IE) due to...
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Prophylactic Cefazolin Dosing in Obesity—a Systematic Review
Currently, there is no consensus on whether a standard 2-g prophylactic cefazolin dose provides sufficient antimicrobial coverage in obese surgical...
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Outcome of preoperative cefazolin use for infection prophylaxis in patients with self-reported penicillin allergy
BackgroundCephalosporins are the preferred antibiotics for prophylaxis against surgical site infections. Most studies give a rate of combined IgE and...