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1. CMYC-initiated HNF1A-AS1 overexpression maintains the stemness of gastric cancer cells

   Cancer stem cells (CSCs) are believed to be responsible for cancer metastasis and recurrence due to their self-renewal ability and resistance to...

   Ruinan Zhao, **angyu Guo, ... Haiting Liu in Cell Death & Disease

   Article Open access 23 April 2024
   

2. Machine learning-identified stemness features and constructed stemness-related subtype with prognosis, chemotherapy, and immunotherapy responses for non-small cell lung cancer patients

   Aim

   This study aimed to explore a novel subtype classification method based on the stemness characteristics of patients with non-small cell lung...

   Mingshan Liu, Ruihao Zhou, ... **gtao Zhang in Stem Cell Research & Therapy

   Article Open access 07 September 2023
   

3. NELF and PAF1C complexes are core transcriptional machineries controlling colon cancer stemness

   Mutations in APC , found in 80% of colon caner, enhance β-catenin stabilization, which is the initial step of colonic tumorigenesis. However, the core...

   Koji Aoki, Akari Nitta, Ayumi Igarashi in Oncogene

   Article Open access 05 January 2024
   

4. Tumor microenvironment-induced FOXM1 regulates ovarian cancer stemness

   In ovarian tumors, the omental microenvironment profoundly influences the behavior of cancer cells and sustains the acquisition of stem-like traits,...

   Chiara Battistini, Hilary A. Kenny, ... Ugo Cavallaro in Cell Death & Disease

   Article Open access 28 May 2024
   

5. Stemness signature and targeted therapeutic drugs identification for Triple Negative Breast Cancer

   Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and carries the worst prognosis, characterized by the lack of...

   Samina Gul, Jianyu Pang, ... Wenru Tang in Scientific Data

   Article Open access 20 November 2023
   

6. IL20RB signaling enhances stemness and chemotherapy resistance in pancreatic cancer

   Objective

   Pancreatic cancer is an aggressive malignancy with high mortality, and cancer cell stemness and related drug resistance are considered...

   **ao-hui Li, Gui-zhong Huang, ... **ao-jun Lin in Journal of Translational Medicine

   Article Open access 14 December 2023
   

7. Nucleoporin 93 Regulates Cancer Cell Growth and Stemness in Bladder Cancer via Wnt/β-Catenin Signaling

   Bladder cancer (BLCA) is a prevalent cancer type with an unmet need for new therapeutic strategies. Nucleoporin 93 (Nup93) is implicated in the...

   Zhe Wang, **g Zhang, ... Wenlong Miao in Molecular Biotechnology

   Article 14 May 2024
   

8. Cuproptosis engages in c-Myc-mediated breast cancer stemness

   Background

   Intra-tumoral heterogeneity (ITH) is a distinguished hallmark of cancer, and cancer stem cells (CSCs) contribute to this malignant...

   Runtian Wang, Kun Xu, ... **aoxiang Guan in Journal of Translational Medicine

   Article Open access 23 June 2023
   

9. Integrative multi-omics analysis unveils stemness-associated molecular subtypes in prostate cancer and pan-cancer: prognostic and therapeutic significance

   Background

   Prostate cancer (PCA) is the fifth leading cause of cancer-related deaths worldwide, with limited treatment options in the advanced stages....

   Kun Zheng, Youlong Hai, ... Jie Hao in Journal of Translational Medicine

   Article Open access 07 November 2023
   

10. Pancreatic cancer stemness: dynamic status in malignant progression

    Pancreatic cancer (PC) is one of the most aggressive malignancies worldwide. Increasing evidence suggests that the capacity for self-renewal,...

    Yutong Zhao, Cheng Qin, ... Weibin Wang in Journal of Experimental & Clinical Cancer Research

    Article Open access 13 May 2023
    

11. ID1 expressing macrophages support cancer cell stemness and limit CD8⁺ T cell infiltration in colorectal cancer

    Elimination of cancer stem cells (CSCs) and reinvigoration of antitumor immunity remain unmet challenges for cancer therapy. Tumor-associated...

    Shuang Shang, Chen Yang, ... Fang Hua in Nature Communications

    Article Open access 23 November 2023
    

12. Development of a stemness-related prognostic index to provide therapeutic strategies for bladder cancer

    Bladder cancer (BC) is a heterogeneous disease with varying clinical outcomes. Recent evidence suggests that cancer progression involves the...

    Shi Fu, Zhiyong Tan, ... Haifeng Wang in npj Precision Oncology

    Article Open access 20 January 2024
    

13. POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase

    Gastric cancer (GC) contains subpopulations of cancer stem cells (CSCs), which are described as the main contributors in tumor initiation and...

    Yanmei Peng, Wenbo Zheng, ... Jiang Yu in Cell Death & Disease

    Article Open access 04 April 2024
    

14. Three-Dimensional Tumor Models to Study Cancer Stemness-Mediated Drug Resistance

    Solid tumors often contain genetically different populations of cancer cells, stromal cells, various structural and soluble proteins, and other...

    Astha Lamichhane, Hossein Tavana in Cellular and Molecular Bioengineering

    Article Open access 21 February 2024
    

15. LncRNA H19 Participates in Leukemia Inhibitory Factor Mediated Stemness Promotion in Colorectal Cancer Cells

    Colorectal cancer (CRC) is a common human malignancy and the third leading cause of cancer-related death worldwide. Cancer stem cells (CSCs) were...

    Min Zhu, Ruihong Yu, ... Boyu Du in Biochemical Genetics

    Article 10 January 2024
    

16. Periostin facilitates ovarian cancer recurrence by enhancing cancer stemness

    The lethality of epithelial ovarian cancer (OC) is largely due to a high rate of recurrence and development of chemoresistance, which requires...

    Zhiqing Huang, Olivia Byrd, ... Susan K. Murphy in Scientific Reports

    Article Open access 04 December 2023
    

17. Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress

    Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor relapse, yet how amino acid metabolism promotes CSC...

    Bai Cui, Bin He, ... Fei Peng in Cell Death & Disease

    Article Open access 16 October 2023
    

18. Bestatin attenuates breast cancer stemness by targeting puromycin-sensitive aminopeptidase

    Breast cancer is a prevalent malignant tumor among women with an increasing incidence rate annually. Breast cancer stem cells (BCSCs) are integral in...

    Yan Ma, **ntong Yang, ... Hui Gao in Discover Oncology

    Article Open access 30 May 2024
    

19. Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness

    Cancer cell receives extracellular signal inputs to obtain a stem-like status, yet how t umor m icro e nvironmental (TME) neural signals steer cancer...

    Bin He, Rui Gao, ... Quentin Liu in Signal Transduction and Targeted Therapy

    Article Open access 19 July 2023
    

20. Ropivacaine as a novel AKT1 specific inhibitor regulates the stemness of breast cancer

    Background

    Ropivacaine, a local anesthetic, exhibits anti-tumor effects in various cancer types. However, its specific functions and the molecular...

    Lin Ding, Hui Jiang, ... Yong Zhu in Journal of Experimental & Clinical Cancer Research

    Article Open access 25 March 2024