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1. CXCR4

   in Dictionary of Toxicology

   Reference work entry 2024
   

2. CXCR4 Theranostics: A Potential Game Changer in Solid Tumors and Hematological Malignancies

   An overexpression of CXCR4 receptors is reported in at least 30 different human solid tumors and hematological malignancies. This overexpression is...

   Singh Bal**der, Watts Ankit, ... Digambar Behera in Beyond Becquerel and Biology to Precision Radiomolecular Oncology: Festschrift in Honor of Richard P. Baum

   Chapter Open access 2024
   

3. Case Study #5: CXCR4-Targeted Radiotherapeutics

   Radiopharmaceutical therapy (RPT) has become a mainstay of modern oncology but remains limited to solid tumors, including orphan diseases such as...

   Andreas K. Buck, Heribert Hänscheid, ... Rudolf A. Werner in Radiopharmaceutical Therapy

   Chapter 2023
   

4. Targeting CXCR4/CXCL12 axis via [¹⁷⁷Lu]Lu-DOTAGA.(SA.FAPi)₂ with CXCR4 antagonist in triple-negative breast cancer

   Purpose

   Radiopharmaceutical therapies targeting fibroblast activation protein (FAP) have shown promising efficacy against many tumor types. But...

   Guangfa Bao, Ziqiang Wang, ... **aohua Zhu in European Journal of Nuclear Medicine and Molecular Imaging

   Article Open access 08 April 2024
   

5. Structural basis of dimerization of chemokine receptors CCR5 and CXCR4

   G protein-coupled receptors (GPCRs) are prominent drug targets responsible for extracellular-to-intracellular signal transduction. GPCRs can form...

   Daniele Di Marino, Paolo Conflitti, ... Vittorio Limongelli in Nature Communications

   Article Open access 13 October 2023
   

6. Interplay between androgen and CXCR4 chemokine signaling in myelin repair

   In men, reduced levels of testosterone are associated with the prevalence and progression of multiple sclerosis (MS), a chronic and disabling...

   Narimène Asbelaoui, Charly Abi-Ghanem, ... Abdel Mouman Ghoumari in Acta Neuropathologica Communications

   Article Open access 30 January 2024
   

7. CXCR4 overexpression in chronic lymphocytic leukemia associates with poorer prognosis: A prospective, single-center, observational study

   Controversial data have been reported on the prognostic value of C-X-C motif chemokine receptor 4 (CXCR4) in chronic lymphocytic leukemia (CLL). This...

   **nran Xue, Zhihao Wen, ... Hongyan Liao in Genes & Immunity

   Article 17 February 2024
   

8. CXCL12–CXCR4 Axis in Cancer Metastasis

   The malignancy that leads to the most fatalities is characterized by metastasis. Due to continually develo** research in the biology of cancer as...

   Manzoor Ahmad Mir, Ab Qayoom Naik, ... Tabassum Zafar in Cytokine and Chemokine Networks in Cancer

   Chapter 2023
   

9. LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration

   Background

   G protein-coupled receptor heteromerization is believed to exert dynamic regulatory impact on signal transduction. CXC chemokine receptor 4...

   Jong Min Hong, **-Woo Lee, ... Won-Ki Huh in Cell Communication and Signaling

   Article Open access 25 September 2023
   

10. Glucocorticoids paradoxically promote steroid resistance in B cell acute lymphoblastic leukemia through CXCR4/PLC signaling

    Glucocorticoid (GC) resistance in childhood relapsed B-cell acute lymphoblastic leukemia (B-ALL) represents an important challenge. Despite decades...

    Souleymane Abdoul-Azize, Rihab Hami, ... Olivier Boyer in Nature Communications

    Article Open access 29 May 2024
    

11. Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients

    Background

    Tregs trafficking is controlled by CXCR4. In Renal Cell Carcinoma (RCC), the effect of the new CXCR4 antagonist, R54, was explored in...

    Sara Santagata, Giuseppina Rea, ... Stefania Scala in British Journal of Cancer

    Article Open access 04 May 2024
    

12. Influence of corticosteroid treatment on CXCR4 expression in DLBCL

    Background

    CXCR4-targeted radioligand therapy (RLT) with [ ¹⁷⁷ Lu]Lu/[ ⁹⁰ Y]Y-PentixaTher has recently evolved as a promising therapeutic option for...

    Sebastian Martin, David Viertl, ... Margret Schottelius in EJNMMI Research

    Article Open access 10 May 2023
    

13. CXC chemokine receptor 4 (CXCR4) blockade in cancer treatment

    CXC chemokine receptor type 4 (CXCR4) is a member of the G protein-coupled receptors (GPCRs) superfamily and is specific for CXC chemokine ligand 12...

    Shunshun Bao, Mohammad Darvishi, ... Reza Akhavan-Sigari in Journal of Cancer Research and Clinical Oncology

    Article 11 March 2023
    

14. WHIM Syndrome-linked CXCR4 mutations drive osteoporosis

    WHIM Syndrome is a rare immunodeficiency caused by gain-of-function CXCR4 mutations. Here we report a decrease in bone mineral density in 25% of WHIM...

    Adrienne Anginot, Julie Nguyen, ... Karl Balabanian in Nature Communications

    Article Open access 12 April 2023
    

15. CREB1-driven CXCR4^hi neutrophils promote skin inflammation in mouse models and human patients

    Neutrophils have a pathogenic function in inflammation via releasing pro-inflammatory mediators or neutrophil extracellular traps (NETs). However,...

    Jiaoling Chen, Yaxing Bai, ... Shuai Shao in Nature Communications

    Article Open access 22 September 2023
    

16. Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL

    Malignant transformation of T-cell progenitors causes T-cell acute lymphoblastic leukemia (T-ALL), an aggressive childhood lymphoproliferative...

    Ilaria Sergio, Claudia Varricchio, ... Maria Pia Felli in Oncogene

    Article 21 June 2024
    

17. Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system

    Chemokine receptors constitute an important subfamily of G protein-coupled receptors (GPCRs), and they are critically involved in a broad range of...

    Parishmita Sarma, Carlo Marion C. Carino, ... Arun K. Shukla in Nature Communications

    Article Open access 09 August 2023
    

18. Demethylation in promoter region of severely damaged hepatocytes enhances chemokine receptor CXCR4 gene expression

    The liver is known to possess remarkable regenerative potential, but persistent inflammation or severe acute injury can lead to liver fibrosis and...

    Chihiro Ito, Ryuma Haraguchi, ... Sohei Kitazawa in Histochemistry and Cell Biology

    Article 02 August 2023
    

19. Caulis Spatholobi extracts inhibit osteosarcoma growth and metastasis through suppression of CXCR4/PI3K/AKT signaling

    Background

    The therapeutic potential of Caulis Spatholobi (CS) extracts against various cancers has been well documented, yet its impact and mechanism...

    Yang Jiang, Yemei Gao, ... Renxian Wang in Journal of Orthopaedic Surgery and Research

    Article Open access 21 December 2023
    

20. The importance of CXCR4 expression in tumor stroma as a potential biomarker in pancreatic cancer

    Background

    Pancreatic ductal adenocarcinoma (PDAC) is one of the main causes of cancer mortality in the world. A characteristic feature of this cancer...

    Raquel Bodoque-Villar, David Padilla-Valverde, ... Leticia Serrano-Oviedo in World Journal of Surgical Oncology

    Article Open access 12 September 2023