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Alopecia areata-like pattern of baldness: the most recent update and the expansion of novel phenotype and genotype in the CTNNB1 gene
Neurodevelopmental disorder with spastic diplegia and visual defects (NEDSDV) is a rare autosomal dominant genetic disorder caused by genetic...
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Desmoplastic fibroma of the pediatric cranium with CTNNB1 mutation: case report and literature review
PurposeDesmoplastic fibroma (DF) is an uncommon intermediate bone tumor rarely involving the skull with unidentified pathogenesis. We report the...
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Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression
BackgroundThe catenin beta 1 gene (CTNNB1) plays a crucial role in the malignant progression of various cancers. Recent studies have suggested that...
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A novel de novo truncating variant in a Hungarian patient with CTNNB1 neurodevelopmental disorder
PurposeWe aimed to elucidate the underlying disease in a Hungarian family, with only one affected family member, a 16-year-old male Hungarian...
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Identification of a novel de novo mutation in the CTNNB1 gene in an Iranian patient with intellectual disability
CTNNB1 encodes for the β-catenin protein, a component of the cadherin adhesion complex, which regulates cell–cell adhesion and gene expression in the...
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RUVBL1-modulated chromatin remodeling alters the transcriptional activity of oncogenic CTNNB1 in uveal melanoma
Recent years have witnessed an increasing research interest in the therapeutic value of aberrant chromatin regulatory processes in carcinogenesis....
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CTNNB1 mutation-driven hybrid tumor: desmoid fibromatosis with an unusual associated epithelioid component arising in association with a neuromuscular choristoma
CTNNB1 mutations play important roles in the development of soft tissue tumors, such as desmoid fibromatosis (DF), sinonasal tract angiofibroma,...
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Rare histologic transformation of a CTNNB1 (β-catenin) mutated prostate cancer with aggressive clinical course
BackgroundCatenin (Cadherin-Associated Protein), Beta 1 ( CTNNB1) genomic alterations are rare in prostate cancer (PCa). Gain-of-function mutations...
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A Ctnnb1 enhancer regulates neocortical neurogenesis by controlling the abundance of intermediate progenitors
β-catenin-dependent canonical Wnt signaling plays a plethora of roles in neocortex (Ncx) development, but its function in regulating the abundance of...
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SNHG1 functions as a ceRNA in hypertrophic scar fibroblast proliferation and apoptosis through miR-320b/CTNNB1 axis
Hypertrophic scar (HS) is a fibrotic disease caused by skin injury. Competing endogenous RNA (ceRNA) has been demonstrated to implicate in the...
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m6A demethylase FTO regulate CTNNB1 to promote adipogenesis of chicken preadipocyte
BackgroundN6-methyladenosine (m 6 A) is an abundant post-transcriptional RNA modification that affects various biological processes. The fat mass and...
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RBM3 suppresses stemness remodeling of prostate cancer in bone microenvironment by modulating N6-methyladenosine on CTNNB1 mRNA
Bone metastasis is the most happened metastatic event in prostate cancer (PCa) and needs a large effort in treatment. When PCa metastasizes to the...
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CTNNB1 polymorphism (rs121913407) in circulating tumor DNA (ctDNA) in Egyptian hepatocellular carcinoma patients
BackgroundHepatocellular carcinoma (HCC) represents the sixth most common cancer worldwide and the fourth in Egypt. Persistent inflammation and...
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Recurrent CTNNB1 mutations in craniofacial osteomas
Osteoma is a benign bone forming tumor predominantly arising on the surface of craniofacial bones. While the vast majority of osteomas develops...
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CTNNB1 p.D32A (c.95A > C) somatic mutation in stage I grade 1 endometrioid endometrial carcinoma with lung metastasis: a case report
BackgroundMost endometrial cancers are of low histological grade and uterine-confined, with a high 5-year survival rate. However, a small subset of...
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Characterization of novel CTNNB1 mutation in Craniopharyngioma by whole-genome sequencing
BackgroundCraniopharyngioma (CP) is rare histologically benign but clinically challenging tumor because of its intimate relationship with the...
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The clinical significance of adenomatous polyposis coli (APC) and catenin Beta 1 (CTNNB1) genetic aberrations in patients with melanoma
BackgroundMelanoma-intrinsic activated β-catenin pathway, the product of the catenin beta 1 ( CTNNB1) gene, has been associated with low/absent...
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CTNNB1 mutations, TERT polymorphism and CD8+ cell densities in resected hepatocellular carcinoma are associated with longer time to recurrence
BackgroundHepatocellular carcinoma (HCC) is a fatal disease characterized by early genetic alterations in telomerase reverse transcriptase promoter...
