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De novo identification of CD4+ T cell epitopes
CD4 + T cells recognize peptide antigens presented on class II major histocompatibility complex (MHC-II) molecules to carry out their function. The...
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Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity
Antigen recognition by the T cell receptor (TCR) of CD4 + T cells can be greatly enhanced by the coreceptor CD4. Yet, understanding of the molecular...
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Map** autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation
CD4+ T cells are pivotal cells playing roles in the orchestration of humoral and cytotoxic immune responses. It is known that CD4+ T cell...
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CD4+ T cell memory
Specialized subpopulations of CD4 + T cells survey major histocompatibility complex class II–peptide complexes to control phagosomal infections, help...
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Single-cell multiomic analysis of thymocyte development reveals drivers of CD4+ T cell and CD8+ T cell lineage commitment
The development of CD4 + T cells and CD8 + T cells in the thymus is critical to adaptive immunity and is widely studied as a model of lineage...
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CD4+ T cell-induced inflammatory cell death controls immune-evasive tumours
Most clinically applied cancer immunotherapies rely on the ability of CD8 + cytolytic T cells to directly recognize and kill tumour cells
1 –3 . These...
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A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs
While CD4 + T cells are a prerequisite for CD8 + T cell-mediated protection against intracellular hepatotropic pathogens, the mechanisms facilitating...
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CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors
CD4 + T cells can "help” or "license” conventional type 1 dendritic cells (cDC1s) to induce CD8 + cytotoxic T lymphocyte (CTL) anticancer responses, as...
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Acacetin alleviates autoimmune myocarditis by regulating CD4+ T cell mitochondrial respiration
BackgroundMyocarditis refers to an autoimmune inflammatory response of the myocardium with characterization of self-reactive CD4+ T cell activation,...
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Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class II-negative solid tumors
CD4 + T cells play key roles in a range of immune responses, either as direct effectors or through accessory cells, including CD8 + T lymphocytes. In...
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CD4+ T cell immunity is dependent on an intrinsic stem-like program
CD4 + T cells are central to various immune responses, but the molecular programs that drive and maintain CD4 + T cell immunity are not entirely clear....
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CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity
Antiviral CD8 + T cell immunity depends on the integration of various contextual cues, but how antigen-presenting cells (APCs) consolidate these...
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Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma
Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T cell rich tumors fail to respond to immune checkpoint...
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Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis
BackgroundImmune-mediated arthritis is a group of autoinflammatory diseases, where the patient’s own immune system attacks and destroys synovial...
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Insulin and IGF-1 have both overlap** and distinct effects on CD4+ T cell mitochondria, metabolism, and function
Insulin and insulin-like growth factor 1 (IGF-1) are metabolic hormones with known effects on CD4 + T cells through insulin receptor (IR) and IGF-1...
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Memory CD8 T cells are vulnerable to chronic IFN-γ signals but not to CD4 T cell deficiency in MHCII-deficient mice
The mechanisms by which the number of memory CD8 T cells is stably maintained remains incompletely understood. It has been postulated that...
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Prmt5 deficiency inhibits CD4+ T-cell Klf2/S1pr1 expression and ameliorates EAE disease
BackgroundProtein arginine methyltransferase 5 (Prmt5) is the main type II methyltransferase, catalyzes protein arginine residue symmetric...
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CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disorder characterized by the loss of upper and lower motor...
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Cytolytic circumsporozoite-specific memory CD4+ T cell clones are expanded during Plasmodium falciparum infection
Clinical immunity against Plasmodium falciparum infection develops in residents of malaria endemic regions, manifesting in reduced clinical symptoms...
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Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4+ T cell fate
Follicular helper T (Tfh) cells are essential for germinal center (GC) B cell responses. However, it is not clear which PD-1 + CXCR5 + Bcl6 + CD4 + T cells...
