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Anti-Caspr-conjugated gold nanoparticles emergence as a novel approach in the treatment of EAE animal model
Multiple sclerosis (MS) is a chronic autoimmune disorder of central nervous system which is increasing worldwide. Although immunosuppressive agents...
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Inversion recovery and saturation recovery pulmonary vein MR angiography using an image based navigator fluoro trigger and variable-density 3D cartesian sampling with spiral-like order
Contrast enhanced pulmonary vein magnetic resonance angiography (PV CE-MRA) has value in atrial ablation pre-procedural planning. We aimed to provide...
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Complement-membrane regulatory proteins are absent from the nodes of Ranvier in the peripheral nervous system
BackgroundHomozygous CD59-deficient patients manifest with recurrent peripheral neuropathy resembling Guillain-Barré syndrome (GBS), hemolytic anemia...
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Genetic deletion of Krüppel-like factor 11 aggravates traumatic brain injury
BackgroundThe long-term functional recovery of traumatic brain injury (TBI) is hampered by pathological events, such as parenchymal...
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Anti-LGI1 encephalitis recurring 3 years after the first episode: a case report
BackgroundPatients with antibodies against leucine-rich glioma-inactivated 1 (LGI1) present with limbic encephalitis, which is clinically...
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Finding New Ways How to Control BACE1
Recently, all applications of BACE1 inhibitors failed as therapeutical targets for Alzheimer´s disease (AD) due to severe side effects. Therefore,...
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The Node of Ranvier as an Interface for Axo-Glial Interactions: Perturbation of Axo-Glial Interactions in Various Neurological Disorders
The action potential conduction along the axon is highly dependent on the healthy interactions between the axon and myelin-producing glial cells....
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White and gray matter integrity evaluated by MRI-DTI can serve as noninvasive and reliable indicators of structural and functional alterations in chronic neurotrauma
We aimed to evaluate whether white and gray matter microstructure changes observed with magnetic resonance imaging (MRI)-based diffusion tensor...
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Reduced length of nodes of Ranvier and altered proteoglycan immunoreactivity in prefrontal white matter in major depressive disorder and chronically stressed rats
Major depressive disorder (MDD) and chronic unpredictable stress (CUS) in animals feature comparable cellular and molecular disturbances that involve...
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Systemic Inflammation Leads to Changes in the Intracellular Localization of KLK6 in Oligodendrocytes in Spinal Cord White Matter
Axonal injury and demyelination occur in demyelinating diseases, such as multiple sclerosis, and the detachment of myelin from axons precedes its...
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Concussion leads to widespread axonal sodium channel loss and disruption of the node of Ranvier
Despite being a major health concern, little is known about the pathophysiological changes that underly concussion. Nonetheless, emerging evidence...
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Grafted human-induced pluripotent stem cells-derived oligodendrocyte progenitor cells combined with human umbilical vein endothelial cells contribute to functional recovery following spinal cord injury
BackgroundSpinal cord injury (SCI) is a devastating disease that causes extensive damage to oligodendrocytes and neurons leading to demyelination and...
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Sex differences in the extent of acute axonal pathologies after experimental concussion
Although human females appear be at a higher risk of concussion and suffer worse outcomes than males, underlying mechanisms remain unclear. With...
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Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis
Multiple sclerosis (MS) is a chronic neurological disease characterized by inflammatory demyelination that disrupts neuronal transmission resulting...
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Letter I
Isaacs’s syndrome (Isaacs-Mertens syndrome, Isaacs-Zschoke-Mertens syndrome, immune-mediated neuromyotonia) is an antibody-mediated disfunction of...
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Minimum effective dose of clemastine in a mouse model of preterm white matter injury
BackgroundPreterm white matter injury (PWMI) is the most common cause of brain injury in premature neonates. PWMI involves a differentiation arrest...
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SHANK3 deficiency leads to myelin defects in the central and peripheral nervous system
Mutations or deletions of the SHANK3 gene are causative for Phelan–McDermid syndrome (PMDS), a syndromic form of autism spectrum disorders (ASDs). We...
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Acute axon damage and demyelination are mitigated by 4-aminopyridine (4-AP) therapy after experimental traumatic brain injury
Damage to long axons in white matter tracts is a major pathology in closed head traumatic brain injury (TBI). Acute TBI treatments are needed that...
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Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects
Axon degeneration and functional decline in myelin diseases are often attributed to loss of myelin but their relation is not fully understood....
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Dark Rearing in the Visual Critical Period Causes Structural Changes in Myelinated Axons in the Adult Mouse Visual Pathway
An appropriate sensory experience during the early developmental period is important for brain maturation. Dark rearing during the visual critical...
