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1. Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

   Defects in insulin processing and granule maturation are linked to pancreatic beta-cell failure during type 2 diabetes (T2D). Phosphatidylinositol...

   Yu-Te Yeh, Chandan Sona, ... Matthew N. Poy in Nature Communications

   Article Open access 17 July 2023
   

2. Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding

   Insufficient insulin secretion is a hallmark of type 2 diabetes and has been attributed to beta cell identity loss characterized by decreased...

   Adriana Ibarra Urizar, Michala Prause, ... Nils Billestrup in Cell Death & Disease

   Article Open access 05 July 2023
   

3. Severe COVID-19 associated hyperglycemia is caused by beta cell dysfunction: a prospective cohort study

   Background

   COVID-19, an infectious disease caused by SARS-CoV-2, was shown to be associated with an increased risk of new-onset diabetes. Mechanisms...

   Jan Gojda, Kateřina Koudelková, ... Sabrina Schlesinger in Nutrition & Diabetes

   Article Open access 17 July 2023
   

4. Modelling of Beta Cell Pathophysiology Using Stem Cell-Derived Islets

   Diabetes mellitus is a family of metabolic disorders that arise from the loss or dysfunction of insulin secreting pancreatic beta cells. Many forms...

   Tom Barsby, Hossam Montaser, ... Timo Otonkoski in Pluripotent Stem Cell Therapy for Diabetes

   Chapter 2023
   

5. Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes

   Dysfunctional pancreatic islet beta cells are a hallmark of type 2 diabetes (T2D), but a comprehensive understanding of the underlying mechanisms,...

   Gaowei Wang, Joshua Chiou, ... Maike Sander in Nature Genetics

   Article 25 May 2023
   

6. KSRP improves pancreatic beta cell function and survival

   Impaired insulin production and/or secretion by pancreatic beta cells can lead to high blood glucose levels and type 2 diabetes (T2D). Therefore,...

   Leticia Barssotti, Gabriela Moreira Soares, ... Helena Cristina Lima Barbosa in Scientific Reports

   Article Open access 13 March 2024
   

7. (+)-Catechin mitigates impairment in insulin secretion and beta cell damage in methylglyoxal-induced pancreatic beta cells

   Background

   The formation of advanced glycation end products (AGEs) is the central process contributing to diabetic complications in diabetic...

   Nair Anaga, Krishnan Lekshmy, Jayamurthy Purushothaman in Molecular Biology Reports

   Article 23 March 2024
   

8. Apolipoprotein C-III is linked to the insulin resistance and beta-cell dysfunction that are present in rheumatoid arthritis

   Background

   Insulin resistance and beta-cell dysfunction are manifestations of rheumatoid arthritis (RA). Apolipoprotein C-III (ApoC3) has been...

   Candelaria Martín-González, Tomás Martín-Folgueras, ... Iván Ferraz-Amaro in Arthritis Research & Therapy

   Article Open access 30 May 2022

9. Differential contribution of alpha and beta cell dysfunction to impaired fasting glucose and impaired glucose tolerance

   Aims/hypothesis

   People with isolated impaired fasting glucose (IFG) have normal beta cell function. We hypothesised that an increased glucose...

   Jacob D. Kohlenberg, Marcello C. Laurenti, ... Adrian Vella in Diabetologia

   Article 16 September 2022
   

10. Reconstruction of a Pancreatic Beta Cell Network From Heterogeneous Functional Measurements

    Intercellular heterogeneity is fundamental to most biological tissues. For some cell types, heterogeneity is thought to be responsible for distinct...

    Roshni Shetty, Radhika Singh-Agarwal, ... Andrew G Edwards in Computational Physiology

    Chapter Open access 2024
    

11. Determinants of sustained stabilization of beta-cell function following short-term insulin therapy in type 2 diabetes

    In early type 2 diabetes, the strategy of “induction” with short-term intensive insulin therapy followed by “maintenance” with metformin can...

    Ravi Retnakaran, Jiajie Pu, ... Bernard Zinman in Nature Communications

    Article Open access 27 July 2023
    

12. Lipotoxicity-induced circGlis3 impairs beta cell function and is transmitted by exosomes to promote islet endothelial cell dysfunction

    Aims/hypothesis

    Lipotoxicity constitutes the major driving force for type 2 diabetes. Circular RNAs (circRNAs) play important roles in regulating beta...

    Li **ong, Li Chen, ... Haipeng **ao in Diabetologia

    Article 09 November 2021
    

13. Sex-dependent intra-islet structural rearrangements affecting alpha-to-beta cell interactions lead to adaptive enhancements of Ca²⁺ dynamics in prediabetic beta cells

    Aims/hypothesis

    Prediabetic pancreatic beta cells can adapt their function to maintain normoglycaemia for a limited period of time, after which...

    Montse Visa, Per-Olof Berggren in Diabetologia

    Article Open access 30 May 2024
    

14. XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice

    Aims/hypothesis

    Pancreatic beta cell dedifferentiation, transdifferentiation into other islet cells and apoptosis have been implicated in beta cell...

    Kailun Lee, Jeng Yie Chan, ... D. Ross Laybutt in Diabetologia

    Article Open access 22 March 2022
    

15. Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death

    Aims/hypothesis

    TNF-α plays a role in pancreatic beta cell loss in type 1 diabetes mellitus. In clinical interventions, TNF-α inhibition preserves...

    Arturo Roca-Rivada, Sandra Marín-Cañas, ... Decio L. Eizirik in Diabetologia

    Article 29 March 2023
    

16. Saturated fatty acid concentrations are predictive of insulin sensitivity and beta cell compensation in dogs

    Chronic feeding of a high fat diet (HFD) in preclinical species induces broad metabolic dysfunction characterized by body weight gain,...

    Matthew Peloquin, Ashley Tovar, ... Dina Juarez-Salinas in Scientific Reports

    Article Open access 02 June 2024
    

17. Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice

    Aims/hypothesis

    N ⁶ -methyladenosine (m ⁶ A) mRNA methylation and m ⁶ A-related proteins (methyltransferase-like 3 [METTL3], methyltransferase-like 14...

    **nzhi Li, Ying Yang, ... Zheng Chen in Diabetologia

    Article 15 March 2023
    

18. Sox9 regulates alternative splicing and pancreatic beta cell function

    Despite significant research, mechanisms underlying the failure of islet beta cells that result in type 2 diabetes (T2D) are still under...

    Sapna Puri, Hasna Maachi, ... Matthias Hebrok in Nature Communications

    Article Open access 18 January 2024
    

19. NADH intraperitoneal injection prevents massive pancreatic beta cell destruction in a streptozotocin-induced diabetes in rats

    Diabetes mellitus is a chronic metabolic disease characterized by persistent hyperglycemia, revealing a decrease in insulin efficiency. The sustained...

    Amina Abdellatif, Karima Bahria, ... Karine Benachour in Histochemistry and Cell Biology

    Article 09 November 2023
    

20. Insufficient TRPM5 Mediates Lipotoxicity-induced Pancreatic β-cell Dysfunction

    Objective

    While the reduction of transient receptor potential channel subfamily M member 5 (TRPM5) has been reported in islet cells from type 2...

    Kai-yuan Wang, Shi-mei Wu, ... **ao Han in Current Medical Science

    Article 22 March 2024