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How does caspases regulation play role in cell decisions? apoptosis and beyond
Caspases are a family of cysteine proteases, and the key factors behind the cellular events which occur during apoptosis and inflammation. However,...
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A Review on Caspases: Key Regulators of Biological Activities and Apoptosis
Caspases are proteolytic enzymes that belong to the cysteine protease family and play a crucial role in homeostasis and programmed cell death....
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Caspases in Alzheimer’s Disease: Mechanism of Activation, Role, and Potential Treatment
With the aging of the population, treatment of conditions emerging in old age, such as neurodegenerative disorders, has become a major medical...
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Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context
Apoptosis, also known as the programmed death of cells, is responsible for maintaining the homeostasis of tissues, and this function is carried out...
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S-(de)-Nitrosylation of Caspases: The Achilles Heel in the Expanding Sea of Cancer Treatment Regimens
Protein S-nitrosylation, or S-nitrosylation, in general, is a redox-regulated posttranslational mechanism that has gained momentum over the years as...
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Drosophila caspases as guardians of host-microbe interactions
An intact cell death machinery is not only crucial for successful embryonic development and tissue homeostasis, but participates also in the defence...
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Expansion and diversity of caspases in Mytilus coruscus contribute to larval metamorphosis and environmental adaptation
BackgroundApoptosis is involved (directly and indirectly) in several physiological processes including tissue remodeling during the development, the...
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Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice
Caspases and poly (ADP-ribose) polymerase 1 (PARP1) have been shown to promote influenza A virus (IAV) replication. However, the relative importance...
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Apoptotic proteins with non-apoptotic activity: expression and function in cancer
Apoptosis is a process of programmed cell death in which a cell commits suicide while maintaining the integrity and architecture of the tissue as a...
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Apoptotic Features in Non-Apoptotic Processes
AbstractApoptosis is the most thoroughly studied type of regulated cell death. Certain events, such as externalization of phosphatidylserine (PS)...
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Apoptotic gene loss in Cnidaria is associated with transition to parasitism
The phylum Cnidaria consists of several morphologically diverse classes including Anthozoa, Cubozoa, Hydrozoa, Polypodiozoa, Scyphozoa, Staurozoa,...
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Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis
During apoptosis, mitochondrial outer membrane permeabilization (MOMP) enables certain mitochondrial matrix macromolecules to escape into the...
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The involvement of caspases in the process of nuclear removal during lens fiber cell differentiation
The terminal differentiation of lens fiber cells involves elimination of their organelles, which must occur while still maintaining their...
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Apoptotic effect of 5-fluorouracil-doxorubicin combination on colorectal cancer cell monolayers and spheroids
BackgroundDrug combination studies help to improve new treatment approaches for colon cancer. Tumor spheroids (3D) are better models than traditional...
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Comparison of immunotherapy mediated by apoptotic bodies, microvesicles and exosomes: apoptotic bodies’ unique anti-inflammatory potential
Immunotherapy, including immunostimulation and immunosuppression, has seen significant development in the last 10 years. Immunostimulation has been...
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Apoptotic caspase inhibits innate immune signaling by cleaving NF-κBs in both Mammals and Flies
Host organisms use different innate immune mechanisms to defend against pathogenic infections, while tight control of innate immunity is essential...
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Magnetospirillum magneticum triggers apoptotic pathways in human breast cancer cells
The use of bacteria in cancer immunotherapy has the potential to bypass many shortcomings of conventional treatments. The ability of anaerobic...
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Novel 3-(pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile derivatives induce intrinsic and extrinsic apoptotic death mediated P53 in HCT116 colon carcinoma
A novel series of α-cyano indolylchalcones was prepared, and their chemical structures were confirmed based on the different spectral data. Among...
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Proteome integral solubility alteration high-throughput proteomics assay identifies Collectin-12 as a non-apoptotic microglial caspase-3 substrate
Caspases are a family of proteins mostly known for their role in the activation of the apoptotic pathway leading to cell death. In the last decade,...
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Diverse maturity-dependent and complementary anti-apoptotic brakes safeguard human iPSC-derived neurons from cell death
In humans, most neurons are born during embryonic development and have to persist throughout the entire lifespan of an individual. Thus, human...
