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Longitudinal metabolomics of human plasma reveal metabolic dynamics and predictive markers of antituberculosis drug-induced liver injury
Tuberculosis (TB) remains the second leading cause of death from a single infectious agent and long-term medication could lead to antituberculosis...
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Management of type 1 immediate hypersensitivity reactions to antituberculosis drug: succesful desensitization
ObjectiveIn this study, it was aimed to investigate the prevalence of type 1 hypersensitivity reaction under tuberculosis treatment and the...
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Epidemiology of tuberculosis and susceptibility to antituberculosis drugs in Reunion Island
BackgroundTuberculosis is the first fatal infectious agent in the world with 1.2 million annual deaths for 10 million cases. Little is known about...
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Synthesis and characterization of hydrazones and their transition metal complexes: antimicrobial, antituberculosis and antioxidant activity
In the search of potential bioactive compounds, we have synthesized new Co(II), Ni(II), Cu(II) and Zn(II) metal complexes of hydrazone ligands...
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Synthesis and characterization of PANI and PANI-indole copolymer and study of their antimalarial and antituberculosis activity
The preparation of polyaniline (PANI) and its copolymer with indole involved a chemical oxidative polymerization method, with benzene sulfonic acid...
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Antituberculosis Activity and Pharmacokinetics of Polymer Conjugates of Isoniazid and Ethambutol
Aconjugate containing isonicotinic acid hydrazide linked with a hydrazone bond (20 ± 2 mol%) and ionically bonded ethambutol (25 ± 2 mol%) was...
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Investigation of antituberculosis, antimicrobial, anti-inflammatory efficacies of newly synthesized transition metal(II) complexes of hydrazone ligands: structural elucidation and theoretical studies
Tuberculosis disease is a serious threat to humans and spreading quickly worldwide, therefore, to find a potent drug, the synthesis of hydrazone...
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Discovery and characterization of genes conferring natural resistance to the antituberculosis antibiotic capreomycin
Metagenomic-based studies have predicted an extraordinary number of potential antibiotic-resistance genes (ARGs). These ARGs are hidden in various...
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Naringenin protects hepato-renal tissues against antituberculosis drugs induced toxic manifestations by modulating interleukin-6, insulin like growth factor-1, biochemical and ultra-structural integrity
BackgroundThe antituberculosis drugs (ATDs), isoniazid, rifampicin, pyrazinamide and ethambutol prompt extreme hepatic and renal damage during...
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Monitoring of an Antituberculosis Drug Degradation under UV Radiation
AbstractDespite the fact that the detection of pharmaceutical products in the various water systems is a subject, which does not date from today,...
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Antibiotic Adjuvant 4-Hexylresorcinol Enhances the Efficiency of Antituberculosis Drugs
We studied the possibility of using 4-hexylresorcinol to increase the efficiency of anti-mycobacterial chemotherapy. In an in vitro experiment,...
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Gelatin Nanoparticles as Carrier for Effective Antituberculosis Drug Delivery in Combination Therapy
Gelatin nanoparticles, synthesized via desolvation, serve as effective carriers for anti-tuberculosis drugs in both single and combination therapies....
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Dzherelo (Immunoxel) as adjunctive therapy to standard antituberculosis treatment in patients with pulmonary tuberculosis: a systematic review and meta-analysis of clinical trials
BackgroundDzherelo (Immunoxel) is one of the few approved immunomodulators that has been shown to produce positive treatment outcomes in patients...
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Discovery of novel antituberculosis agents among 3-phenyl-5-(1-phenyl-1H-[1,2,3]triazol-4-yl)-[1,2,4]oxadiazole derivatives targeting aminoacyl-tRNA synthetases
Antibiotic resistance is a major problem of tuberculosis treatment. This provides the stimulus for the search of novel molecular targets and...
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Mechanisms of Mycobacterium tuberculosis Drug Resistance
AbstractThe review presents the results of investigations of the mechanisms of action of long-used and new antituberculosis drugs, and information...
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Overview of Drug-Resistant Pulmonary Tuberculosis
Drug resistance in Mycobacterium pulmonary tuberculosis is defined as in vitro tests that confirm that Mycobacterium pulmonary tuberculosis has...
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Lipophilic Imidazolylpyridines with Antimicrobial Activity
The reaction of nicotinic and isonicotinic propargylamides with lipophilic aliphatic amines yielded a series of 3- or 4-(5-methyl-1 H -imidazol-2-yl)pyr...
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Polymer Complexes of Rifampicin Antibiotic Based on poly(2-acrylamido-2-methylpropanesulfonic Acid)
Polymer complexes of the homopolymer of 2-acrylamido-2-methylpropanesulfonic acid containing 18.9 – 35.3 wt% of the antituberculosis antibiotic...
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Factors associated with adverse drug reactions or death in very elderly hospitalized patients with pulmonary tuberculosis
The aging of patients with tuberculosis and better therapeutic management for them are recent concerns. This study aimed to identify risk factors for...
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Anterior debridement combined with autogenous iliac bone graft fusion for the treatment of lower cervical tuberculosis: a multicenter retrospective study
BackgroundThis study aimed to analyze the clinical efficacy of one-stage anterior debridement of lower cervical tuberculosis using iliac crest bone...
