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Clinical effect of full endoscopic lumbar annulus fibrosus suture
PurposeThe aim of this study was to investigate the clinical efficacy of full endoscopic lumbar annulus fibrosus suture in the treatment of...
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Celecoxib alleviates nociceptor sensitization mediated by interleukin-1beta-primed annulus fibrosus cells
PurposeThis study aims to analyze the effect of pro-inflammatory cytokine-stimulated human annulus fibrosus cells (hAFCs) on the sensitization of...
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Bone Mesenchymal Stem Cells Inhibit Oxidative Stress–Induced Pyroptosis in Annulus Fibrosus Cells to Alleviate Intervertebral Disc Degeneration Based on Matric Hydrogels
Intervertebral disc degeneration (IVDD) is the primary cause of low back pain. Stem cell transplantation may be a possible approach to promote IVDD....
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Aberrant mechanical loading induces annulus fibrosus cells apoptosis in intervertebral disc degeneration via mechanosensitive ion channel Piezo1
BackgroundIntervertebral disc degeneration (IVDD) is closely associated with the structural damage in the annulus fibrosus (AF). Aberrant mechanical...
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A Biodegradable Polymeric Matrix for the Repair of Annulus Fibrosus Defects in Intervertebral Discs
Background:Tissue defects in the annulus fibrosus (AF) due to intervertebral disc (IVD) degeneration or after nucleodiscectomy have little...
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Fibrotic alterations in human annulus fibrosus correlate with progression of intervertebral disc herniation
BackgroundIntervertebral disc (IVD) herniation is characterized by annulus fibrosus failure (AF) in containing the nucleus pulposus (NP). IVD...
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Radial trend in murine annulus fibrosus fiber orientation is best explained by vertebral growth
PurposeThe intervertebral disc (IVD) annulus fibrosus (AF) is composed of concentric lamellae with alternating right- and left-handed helically...
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Isolation of Nucleus Pulposus and Annulus Fibrosus Cells from the Intervertebral Disc
Cells isolated from the intervertebral disc are often used for in vitro experimentation. Correctly separating the intervertebral disc tissue in...
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Intervertebral disc-intrinsic Hedgehog signaling maintains disc cell phenotypes and prevents disc degeneration through both cell autonomous and non-autonomous mechanisms
Intervertebral disc degeneration is closely related to abnormal phenotypic changes in disc cells. However, the mechanism by which disc cell...
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Lactate oxidative phosphorylation by annulus fibrosus cells: evidence for lactate-dependent metabolic symbiosis in intervertebral discs
BackgroundIntervertebral disc degeneration contributes to low back pain. The avascular intervertebral disc consists of a central hypoxic nucleus...
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Single-cell RNA-seq identifies unique transcriptional landscapes of human nucleus pulposus and annulus fibrosus cells
Intervertebral disc (IVD) disease (IDD) is a complex, multifactorial disease. While various aspects of IDD progression have been reported, the...
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3D virtual reconstruction and quantitative assessment of the human intervertebral disc’s annulus fibrosus: a DTI tractography study
The intervertebral disc’s (IVD) annulus fibrosus (AF) retains the hydrostatic pressure of the nucleus pulposus (NP), controls the range of motion,...
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Biomimetic angle-ply multi-lamellar scaffold for annulus fibrosus tissue engineering
Constructing a biomimetic scaffold that replicates the complex architecture of intervertebral disc annulus fibrosus (AF) remains a major goal in AF...
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Single-Cell Phenoty** of Complex Heterogeneous Tissue
The intervertebral disc (IVD) is a focus of regenerative medicine, with many ongoing clinical trials exploring disc regeneration through injection of...
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Graded-Three-Dimensional Cell-Encapsulating Hydrogel as a Potential Biologic Scaffold for Disc Tissue Engineering
Background:Intervertebral disk (IVD) degeneration, which can cause lower back pain, is a major predisposing factor for disability and can be managed...
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Effects of photobiomodulation on annulus fibrosus cells derived from degenerative disc disease patients exposed to microvascular endothelial cells conditioned medium
Intervertebral disc (IVD) degeneration with chronic low back pain is associated with neo-vascularisation into the deeper IVD regions. During this...
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Mechanobiology of annulus fibrosus and nucleus pulposus cells in intervertebral discs
Low back pain (LBP) is a chronic condition that can affect up to 80% of the global population. It is the number one cause of disability worldwide and...
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The two Poisson’s ratios in annulus fibrosus: relation with the osmo-inelastic features
The annulus fibrosus of the intervertebral disc is a highly complex layered structure in which the inelastic features of the tangled extracellular...
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Diffusion properties of asymptomatic lumbar intervertebral discs in a pediatric cohort: a preliminary study of apparent diffusion coefficient
PurposeTo explore the apparent diffusion coefficients of intervertebral discs in an asymptomatic pediatric cohort.
MethodsWe conducted a prospective...
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GREM1, LRPPRC and SLC39A4 as potential biomarkers of intervertebral disc degeneration: a bioinformatics analysis based on multiple microarray and single-cell sequencing data
BackgroundLow back pain (LBP) has drawn much widespread attention and is a major global health concern. In this field, intervertebral disc...
