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Uncovering novel MHC alleles from RNA-Seq data: expanding the spectrum of MHC class I alleles in sheep
BackgroundMajor histocompatibility complex (MHC) class I glycoproteins present selected peptides or antigens to CD8 + T cells that control the...
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Efficiently Editing Multiple Duplicated Homeologs and Alleles for Recurrent Polyploids
Research on the evolutionary fate of duplicated genes in recurrent polyploids is scarce due to the difficulties in disentangling the different...
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Submitting Novel Full-Length HLA, MIC, and KIR Alleles with TypeLoader2
The Immuno Polymorphism Database (IPD) plays a pivotal role for immunogenetics. Due to technical limitations, genoty** often focuses on specific...
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Full-Length Characterization of Novel HLA-DRB1 Alleles for Reference Database Submission
The prerequisite for successful HLA genoty** is the integrity of the large allele reference database IPD-IMGT/HLA. Consequently, it is in the...
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How to Predict Binding Specificity and Ligands for New MHC-II Alleles with MixMHC2pred
MHC-II molecules are key mediators of antigen presentation in vertebrate species and bind to their ligands with high specificity. The very high...
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Ancestral alleles defined for 70 million cattle variants using a population-based likelihood ratio test
BackgroundThe study of ancestral alleles provides insights into the evolutionary history, selection, and genetic structures of a population. In...
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Biased Expression of Parental Alleles in the Human Placenta
The biased expression of parental alleles plays a fundamental role in the formation of the placenta as a multifunctional organ necessary for the...
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Modifications of Kompetitive Allele-Specific PCR (KASP) Genoty** for Detection of Rare Alleles
KASP is commonly used to genotype bi-allelic SNPs and In/Dels, and the standard protocol works well when both alleles are nearly equally prevalent in...
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Selection against domestication alleles in introduced rabbit populations
Humans have moved domestic animals around the globe for thousands of years. These have occasionally established feral populations in nature, often...
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Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease
The human leukocyte antigen (HLA) locus is associated with more complex diseases than any other locus in the human genome. In many diseases, HLA...
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Base-editing mutagenesis maps alleles to tune human T cell functions
CRISPR-enabled screening is a powerful tool for the discovery of genes that control T cell function and has nominated candidate targets for...
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Clinical course of respiratory tuberculosis relapses in the Kazakh population depending on HLA-DRB1 gene alleles
The study aimed to ascertain the prevalence and frequency of relapses of respiratory tuberculosis (TB) and examine the characteristics of its...
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Relationship Between Hypomorphic Alleles and Mosaicism of X-Linked or Autosomal Mutations
Some genes may harbor different mutant alleles resulting in either a very severe or a rather mild disorder. For example, male embryos hemizygous for...
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CIMBL55: a repository for maize drought resistance alleles
Droughts threaten crop yields worldwide. Compared to other major staple cereal crops, maize ( Zea mays ) is especially sensitive to drought, which can...
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Dominance vs epistasis: the biophysical origins and plasticity of genetic interactions within and between alleles
An important challenge in genetics, evolution and biotechnology is to understand and predict how mutations combine to alter phenotypes, including...
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The Frequency of Intermediate Alleles in Patients with Cerebellar Phenotypes
Cerebellar syndromes are clinically and etiologically heterogeneous and can be classified as hereditary, neurodegenerative non-hereditary, or...
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Hidden prevalence of deletion-inversion bi-alleles in CRISPR-mediated deletions of tandemly arrayed genes in plants
Tandemly arrayed genes (TAGs) with functional redundancy and chromosomal linkage constitute 14 ~ 35% in sequenced plant genomes. The multiplex CRISPR...
