Search Page | SpringerLink

Effects of 5-HT1A Receptor Antagonist and 5-HT2A Receptor Agonist on Morphine Withdrawal

Abstract

Chronic administration of morphine causes physical dependence, possibly through serotonin 5‑HT _1A receptor (5-HT _1AR) and 5-HT _2A receptor (5-HT

Mahdi Ramezani, Siamak Shahidi, ... Nasrin Hashemi-Firouzi in Neurochemical Journal

Article 27 May 2024

Vilazodone, a Selective Serotonin Reuptake Inhibitor with Diminished Impact on Methylphenidate-Induced Gene Regulation in the Striatum: Role of 5-HT1A Receptor

Selective serotonin reuptake inhibitors (SSRIs), including fluoxetine, are frequently combined with medical psychostimulants such as methylphenidate...

Michael Hrabak, Connor Moon, ... Heinz Steiner in Molecular Neurobiology

Article 09 October 2023

Psilocybin restrains activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms

Psilocybin has shown promise for alleviating symptoms of depression and is currently in clinical trials for the treatment of anorexia nervosa (AN), a...

K. Conn, L. K. Milton, ... C. J. Foldi in Molecular Psychiatry

Article Open access 27 April 2024

Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder

Preliminary clinical findings, supported by preclinical studies employing behavioral paradigms such as marble burying, suggest that psilocybin may be...

Sandeep Singh, Alexander Botvinnik, ... Tzuri Lifschytz in Translational Psychiatry

Article Open access 10 May 2023

The Role of 5-HT1A Receptors and Neuronal Nitric Oxide Synthase in a Seizur Induced Kindling Model in Rats

Background and Objective

Dentate gyrus (DG) has a high density of 5-HT1A receptors. It has neural nitric oxide synthase (nNOS), which is involved in...

Zinat Heydarnia Kalati, Omid Gholami, ... Mohammad Mohammad-Zadeh in Neurochemical Research

Article 19 March 2022

Tonic serotonergic input increases the burst firing mode and diminishes the firing rate of reticular thalamic nucleus neurons through 5-HT1A receptors activation in anesthetized rats

The reticular thalamic nucleus (RTn) is a thin shell of GABAergic neurons that covers the dorsal thalamus that regulate the global activity of all...

Rafael Barrientos, Alberto Alatorre, ... Enrique Querejeta in Experimental Brain Research

Article 02 March 2022

Central involvement of 5-HT1A receptors in antinociception induced by photobiomodulation in animal model of neuropathic pain

This study aimed to investigate the central involvement of 5-HT1A receptors in the nociceptive behavior of mice submitted to the chronic constriction...

Gabriela Xavier Santos, Danillo Barbosa, ... Luciana Maria dos Reis in Lasers in Medical Science

Article 22 April 2021

Inhibition of Spinal 5-HT3 Receptor and Spinal Dorsal Horn Neuronal Excitability Alleviates Hyperalgesia in a Rat Model of Parkinson’s Disease

Pain in Parkinson’s disease (PD) is increasingly recognized as a major factor associated with poor life quality of PD patients. However, classic...

Cheng-Jie Li, Li-Ge Zhang, ... Chun-Feng Liu in Molecular Neurobiology

Article 27 September 2022

Alterations in Receptor Genes in Huntington’s Disease

In this chapter, we explored the alterations in receptor genes associated with Huntington’s disease (HD). The dysfunction and composition of receptor...

Tarun Kumar Suvvari, Ayush Anand, ... Mainak Bardhan in Mechanism and Genetic Susceptibility of Neurological Disorders

Chapter 2024

Exploring the impact of trauma type and extent of exposure on posttraumatic alterations in 5-HT1A expression

The long-term behavioral, psychological, and neurobiological effects of exposure to potentially traumatic events vary within the human population....

Michael W. Lewis, Russell T. Jones, Margaret T. Davis in Translational Psychiatry

Article Open access 16 July 2020

The Effect of Subchronic Alcoholization on the Behavior and Monoaminergic Systems of the Brains of Mice with a Predisposition to Depression-Like Behavior

Abstract —Depressive disorders and alcohol dependence are among the most common psychopathologies. It is known that disorders in the functioning of...

D. V. Bazovkina, E. M. Kondaurova, ... A. V. Kulikov in Neurochemical Journal

Article 30 August 2023

Gradients of neurotransmitter receptor expression in the macaque cortex

Dynamics and functions of neural circuits depend on interactions mediated by receptors. Therefore, a comprehensive map of receptor organization...

Sean Froudist-Walsh, Ting Xu, ... Nicola Palomero-Gallagher in Nature Neuroscience

Article Open access 19 June 2023

Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk

Psychiatric and obstetric diseases are growing threats to public health and share high rates of co-morbidity. G protein-coupled receptor signaling...

Serena B. Gumusoglu, Michaela D. Kiel, ... Mark K. Santillan in Neuropsychopharmacology

Article 17 October 2023

The Serotonin 1A (5-HT_1A) Receptor as a Pharmacological Target in Depression

Clinical depression is a common, debilitating and heterogenous disorder. Existing treatments for depression are inadequate for a significant minority...

Alexander L. W. Smith, Catherine J. Harmer, ... Susannah E. Murphy in CNS Drugs

Article 29 June 2023

The discovery, structure, and function of 5-HTR1E serotonin receptor

Serotonin (5-hydroxytryptamine, 5-HT) is a unique neurotransmitter which can regulate various biological processes by activating thirteen different...

Vinay Kumar Sharma, Y. Peng Loh in Cell Communication and Signaling

Article Open access 18 September 2023

Structural genomics of the human dopamine receptor system

The dopaminergic system, including five dopamine receptors (D1R to D5R), plays essential roles in the central nervous system (CNS); and ligands that...

Peiyu Xu, Sijie Huang, ... H. Eric Xu in Cell Research

Article 23 May 2023