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Fluorescence-based investigations of the host–guest inclusion of anilinonaphthalene sulfonic acids (1,8- and 2,6-ANS) by dimethoxypillar[5]arene in nonaqueous solvents
Pillar[n]arenes are a relatively new class of macrocyclic host molecules which have not been extensively studied for their ability to form inclusion...
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Investigation on humic substance and tetracycline interaction mechanism: biophysical and theoretical studies and assessing their effect on biological activity
Tetracycline (TC) is a widely used antibiotic, and evaluating its interaction with humic substances (HS) that act as a complexing agent in the...
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Role of Structural Peculiarities of Flavonoids in Suppressing AGEs Generated From HSA/Glucose System
The pathogenesis of diabetes is related to the amount of advanced glycation end products (AGEs) that are naturally generated from the attachment of...
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PVP-AuNP Impedes Glycation Mediated Hen Egg White Lysozyme Aggregation Under Physiological Condition
Protein glycation a non-enzymatic protein modification, alters the structure of biomolecule leading to several neurodegenerative and other disorders....
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Inhibitory Potential of Carnosine and Aminoguanidine Towards Glycation and Fibrillation of Albumin: In-vitro and Simulation Studies
Carnosine is beta-alanyl histidine, a dipeptide, endogenously produced in our body by the carnosine synthase enzyme. It is an antioxidant, thus...
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Effect of (R)-2-Amino-6-(1R,2S)-1,2-Dihydroxypropyl)-5,6,7,8-Tetrahydropterin-4(3H)-One and Its Structural Analogues on the Temperature Stability of Tryptophan Hydroxylase 2 with the P447R Mutation
The enzyme tryptophan hydroxylase 2 (TPH2) catalyzes the hydroxylation of L-tryptophan to L-5-hydroxytryptophan (5-HTP), the first and the key step...
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Possibility for detecting 14 typical odorants occurring in drinking water by employing human odor-binding protein OBP2a
Odor issues occurring in drinking water have been a big challenge to face for water suppliers globally, which highly commend to develop quick or...
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Small molecules as potent biphasic modulators of protein liquid-liquid phase separation
Liquid-liquid phase separation (LLPS) of proteins that leads to formation of membrane-less organelles is critical to many biochemical processes in...
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Studies on the Binding Interactions of Grass Carp (Ctenopharyngodon idella) Myosin with Chlorogenic Acid and Rosmarinic Acid
There are many polyphenols used for the preservation of fish, but the interaction mechanism between polyphenols and fish protein is rarely reported....
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Thin-Layer Chromatography
Lipid extracts from plants represent a mixture of polar membrane lipids and nonpolar lipids. The main constituents of the polar lipid fraction are...
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Computational insight into in silico analysis and molecular dynamics simulation of the dimer interface residues of ALS-linked hSOD1 forms in apo/holo states: a combined experimental and bioinformatic perspective
The aggregation of misfolded SOD1 proteins in neurodegenerative illnesses is a key pathological hallmark in amyotrophic lateral sclerosis (ALS). SOD1...
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Effects of High Intensity Ultrasonication on Molecular Characteristics and Emulsifying Properties of Rambutan Seed Protein
Rambutan seed protein untreated (No-US) and treated (US) with high intensity ultrasonication (~ 320 W 20 min) had been characterized. LC-MS/MS...
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Efficient Expression in the Prokaryotic Host System, Purification and Structural Analyses of the Recombinant Human ACE2 Catalytic Subunit as a Hybrid Protein with the B Subunit of Cholera Toxin (CTB-ACE2)
Angiotensin-converting enzyme 2 (ACE2) has a specific interaction with the coronavirus spike protein, enabling its entry into human cells. This...
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Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding
Compared to most ATP-site kinase inhibitors, small molecules that target an allosteric pocket have the potential for improved selectivity due to the...
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Insights into the dual nature of αB-crystallin chaperone activity from the p.P39L mutant at the N-terminal region
The substitution of leucine to proline at position 39 (p.P39L) in human αB-crystallin (αB-Cry) has been associated with conflicting interpretations...
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Effect of pH on the Conformational Transition of Silk Fibroin in Aqueous Solution Monitored by Thioflavin-T Fluorescence
In this work, the potential application of the fluorescence dye Thioflavin-T (ThT), which can specifically bind to amyloid, as a powerful tool for...
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Physicochemical and Functional Properties Changes in Myofibrillar Protein Extracted from Channel Catfish by a High-Voltage Electrostatic Field
The effects of high-voltage electrostatic field (HVEF) on the physicochemical and functional properties of myofibrillar protein (MP) extracted from...
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Microwave-Assisted Amination Reaction: A Green Approach
Microwave (MW)-assisted organic reaction is an emerging technique in synthetic organic chemistry for a greener and sustainable development. A wide...
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Functionally active cross-linked protein oligomers formed by homocysteine thiolactone
Deposition of high-order protein oligomers is a common hallmark of a large number of human diseases and therefore, has been of immense medical...
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Fabrication, Structural and Emulsifying Properties of Egg White Protein-Dextran Conjugates through Maillard Reaction
Egg white proteins (EWP) are effective emulsifiers that can be used to form and stabilize oil-in-water emulsions. However, our previous study found...
