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Identification of Predominant Genes that Causes Autism Using MLP
Autism or autism spectrum disorder (ASD) is a developmental disorder comprising a group of psychiatric conditions originating in childhood that...
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Whole blood transcriptome analysis in feedlot cattle after 35 days of supplementation with a β1-adrenergic agonist
Ractopamine HCl (RHC) is supplemented to feedlot cattle to improve feed efficiency and increase carcass weight. Supplementation of RHC clearly...
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Tissue-specific atlas of trans-models for gene regulation elucidates complex regulation patterns
BackgroundDeciphering gene regulation is essential for understanding the underlying mechanisms of healthy and disease states. While the regulatory...
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Single-cell landscape of primary central nervous system diffuse large B-cell lymphoma
Understanding tumor heterogeneity and immune infiltrates within the tumor-immune microenvironment (TIME) is essential for the innovation of...
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Identification of female-enriched and disease-associated microglia (FDAMic) contributes to sexual dimorphism in late-onset Alzheimer’s disease
BackgroundLate-onset Alzheimer’s disease (LOAD) is the most common form of dementia; it disproportionally affects women in terms of both incidence...
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Identification of novel PIEZO1::CBFA2T3 and INO80C::SETBP1 fusion genes in an acute myeloid leukemia patient by RNA-seq
BackgroundFusion genes are recurrent molecular aberrations in acute myeloid leukemia, with significant diagnostic and therapeutic value. The...
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miR155, TREM2, INPP5D: Disease stage and cell type are essential considerations when targeting clinical interventions based on mouse models of Alzheimer’s amyloidopathy
Studies of microglial gene manipulation in mouse models of Alzheimer’s disease (AD) amyloidopathy can cause unpredictable effects on various key...
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The Evolving Landscape of Monocyte/Macrophage System in Glioma
Glioma is one of the most common types of primary brain tumors in adults, highly malignant and resistant to conventional treatments....
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Investigation of cellular communication and signaling pathways in tumor microenvironment for high TP53-expressing osteosarcoma cells through single-cell RNA sequencing
Osteosarcoma (OS) stands as the most prevalent primary bone cancer in children and adolescents, and its limited treatment options often result in...
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Transcriptomics analysis of differentially expressed genes in subcutaneous and perirenal adipose tissue of sheep as affected by their pre- and early postnatal malnutrition histories
BackgroundEarly life malnutrition is known to target adipose tissue with varying impact depending on timing of the insult. This study aimed to...
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Single-cell analysis reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia
Acute myeloid leukemia (AML) microenvironment exhibits cellular and molecular differences among various subtypes. Here, we utilize single-cell RNA...
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Activation of Microglia and Macrophages in Neurodegenerative Diseases
Activation of innate and adaptive immune responses represents a hallmark of neurological disorders. In addition to reactive brain-resident myeloid...
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Role of TREM2 in the Development of Neurodegenerative Diseases After Traumatic Brain Injury
Traumatic brain injury (TBI) has been found as the primary cause of morbidity and disability worldwide, which has posed a significant social and...
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Acute ischemia induces spatially and transcriptionally distinct microglial subclusters
BackgroundDamage in the ischemic core and penumbra after stroke affects patient prognosis. Microglia immediately respond to ischemic insult and...
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Impact of aging on gene expression response to x-ray irradiation using mouse blood
As a radiation biodosimetry tool, gene expression profiling is being developed using mouse and human peripheral blood models. The impact of dose,...
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Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations
BackgroundNeural progenitor cells (NPCs) can be cultivated from develo** brains, reproducing many of the processes that occur during neural...
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Integrative Analysis of the Age-Related Dysregulated Genes Reveals an Inflammation and Immunity-Associated Regulatory Network in Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disease with a long incubation period. While extensive research has led to the construction of long...
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Develo** neural network diagnostic models and potential drugs based on novel identified immune-related biomarkers for celiac disease
BackgroundAs one of the most common intestinal inflammatory diseases, celiac disease (CD) is typically characterized by an autoimmune disorder...
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Selective targeting and modulation of plaque associated microglia via systemic hydroxyl dendrimer administration in an Alzheimer’s disease mouse model
BackgroundIn Alzheimer’s disease (AD), microglia surround extracellular plaques and mount a sustained inflammatory response, contributing to the...
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Transcriptomics unravels molecular changes associated with cilia and COVID-19 in chronic rhinosinusitis with nasal polyps
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common upper respiratory tract complication where the pathogenesis is largely unknown. Herein,...
